DHH and PTCH2

Number of citations of the paper that reports this interaction (PMID 9811851)
27

Data Source:
HPRD (in vivo)

		DHH	PTCH2
Gene Name		desert hedgehog	patched 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane	Integral Component Of Membrane
	Molecular Function	Patched Binding Calcium Ion Binding Protein Binding Peptidase Activity Zinc Ion Binding	Smoothened Binding Hedgehog Receptor Activity Hedgehog Family Protein Binding
	Biological Process	Proteolysis Cell-cell Signaling Spermatid Development Male Sex Determination Response To Estradiol Leydig Cell Differentiation Myelination Regulation Of Steroid Biosynthetic Process	Signal Transduction Epidermis Development Hair Cycle Negative Regulation Of Smoothened Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Hedgehog ligand biogenesis Processing-defective Hh variants abrogate ligand secretion Hh ligand biogenesis disease GPCR ligand binding Metabolic disorders of biological oxidation enzymes Ligand-receptor interactions Release of Hh-Np from the secreting cell Hedgehog 'on' state Signaling by Hedgehog Class B/2 (Secretin family receptors)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Bone mineral density ( 22504420)
Protein-Protein Interactions		3 interactors: HHIP PTCH1 PTCH2	4 interactors: DHH IHH SHH SMO
Entrez ID		50846	8643
HPRD ID		05664	04722
Ensembl ID		ENSG00000139549	ENSG00000117425
Uniprot IDs		O43323	Q9Y6C5
PDB IDs		2WFQ 2WFR 2WG3 3N1G 3N1Q
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Smoothened Signaling Pathway Regulation Of Smoothened Signaling Pathway Smoothened Signaling Pathway Dorsal/ventral Pattern Formation Epithelium Development Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Branching Morphogenesis Of An Epithelial Tube Neural Plate Axis Specification Response To Chlorate Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Epidermis Development Tissue Development Epithelial Tube Morphogenesis Tube Morphogenesis Cell Proliferation Involved In Metanephros Development Pattern Specification Process Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Morphogenesis Of An Epithelium Cell Proliferation Involved In Kidney Development Keratinocyte Proliferation Regulation Of Signal Transduction Cellular Response To Cholesterol Neural Plate Development Cellular Response To Sterol Tissue Morphogenesis Positive Regulation Of Cholesterol Efflux Regulation Of Signaling Negative Regulation Of Multicellular Organism Growth Positive Regulation Of Cholesterol Transport Mammary Gland Epithelial Cell Differentiation Tube Development Response To Cholesterol Pharyngeal System Development Cell Proliferation Regulation Of Cholesterol Efflux Dorsal/ventral Neural Tube Patterning Regulation Of Cholesterol Transport Cell Differentiation Involved In Kidney Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Protein Targeting To Plasma Membrane Organ Morphogenesis Spinal Cord Motor Neuron Differentiation Epithelial Tube Branching Involved In Lung Morphogenesis Negative Regulation Of Osteoblast Differentiation Embryonic Axis Specification Neuroblast Proliferation Ventral Spinal Cord Development Hindlimb Morphogenesis	Intein-mediated Protein Splicing Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Smoothened Signaling Pathway Heart Looping Determination Of Heart Left/right Asymmetry Embryonic Heart Tube Morphogenesis Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Hh Target Transcription Factor Activity Embryonic Heart Tube Development Determination Of Left/right Asymmetry In Lateral Mesoderm Signal Transduction Downstream Of Smoothened Regulation Of Smoothened Signaling Pathway Cell Fate Specification Pancreas Development Somite Development Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Ventral Midline Development Determination Of Left/right Symmetry Regulation Of Stem Cell Proliferation Smoothened Signaling Pathway Determination Of Bilateral Symmetry Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Involved In Regulation Of Granule Cell Precursor Cell Proliferation Epithelial-mesenchymal Cell Signaling Digestive Tract Development Osteoblast Differentiation Digestive System Development Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Lateral Mesoderm Development Thalamus Development Negative Regulation Of Alpha-beta T Cell Differentiation Cell-cell Signaling Positive Regulation Of T Cell Differentiation In Thymus Heart Morphogenesis Negative Regulation Of Alpha-beta T Cell Activation Ossification Regulation Of Epithelial Cell Proliferation Positive Regulation Of Neuroblast Proliferation Embryonic Digestive Tract Morphogenesis Cell Fate Commitment Spinal Cord Dorsal/ventral Patterning Embryonic Organ Morphogenesis Regulation Of T Cell Differentiation In Thymus Spinal Cord Patterning Muscle Tissue Development Hair Follicle Morphogenesis Negative Regulation Of T Cell Differentiation Dorsal/ventral Neural Tube Patterning Positive Regulation Of Kidney Development
Tagcloud ?		avian codes constraints dataset desert diversification duplication evolutionary evolved genomes hedgehog helped hotspots ihh indian invertebrate invertebrates orthologs paralogous paralogs publicly reptilian shh sonic suggestions vertebrate vertebrates wgd	calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9
Tagcloud (Difference) ?		avian codes constraints dataset desert diversification duplication evolutionary evolved genomes hedgehog helped hotspots ihh indian invertebrate invertebrates orthologs paralogous paralogs publicly reptilian shh sonic suggestions vertebrate vertebrates wgd	calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9
Tagcloud (Intersection) ?