DHH

Gene Name		desert hedgehog
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane
	Molecular Function	Patched Binding Calcium Ion Binding Protein Binding Peptidase Activity Zinc Ion Binding
	Biological Process	Proteolysis Cell-cell Signaling Spermatid Development Male Sex Determination Response To Estradiol Leydig Cell Differentiation Myelination Regulation Of Steroid Biosynthetic Process
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Hedgehog ligand biogenesis Processing-defective Hh variants abrogate ligand secretion Hh ligand biogenesis disease GPCR ligand binding Metabolic disorders of biological oxidation enzymes Ligand-receptor interactions Release of Hh-Np from the secreting cell Hedgehog 'on' state Signaling by Hedgehog Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Bone mineral density ( 22504420)
Protein-protein Interactions		3 interactors: HHIP PTCH1 PTCH2
Entrez ID		50846
HPRD ID		05664
Ensembl ID		ENSG00000139549
Uniprot IDs		O43323
PDB IDs		2WFQ 2WFR 2WG3 3N1G 3N1Q
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Smoothened Signaling Pathway Regulation Of Smoothened Signaling Pathway Smoothened Signaling Pathway Dorsal/ventral Pattern Formation Epithelium Development Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Branching Morphogenesis Of An Epithelial Tube Neural Plate Axis Specification Response To Chlorate Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Epidermis Development Tissue Development Epithelial Tube Morphogenesis Tube Morphogenesis Cell Proliferation Involved In Metanephros Development Pattern Specification Process Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Morphogenesis Of An Epithelium Cell Proliferation Involved In Kidney Development Keratinocyte Proliferation Regulation Of Signal Transduction Cellular Response To Cholesterol Neural Plate Development Cellular Response To Sterol Tissue Morphogenesis Positive Regulation Of Cholesterol Efflux Regulation Of Signaling Negative Regulation Of Multicellular Organism Growth Positive Regulation Of Cholesterol Transport Mammary Gland Epithelial Cell Differentiation Tube Development Response To Cholesterol Pharyngeal System Development Cell Proliferation Regulation Of Cholesterol Efflux Dorsal/ventral Neural Tube Patterning Regulation Of Cholesterol Transport Cell Differentiation Involved In Kidney Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Protein Targeting To Plasma Membrane Organ Morphogenesis Spinal Cord Motor Neuron Differentiation Epithelial Tube Branching Involved In Lung Morphogenesis Negative Regulation Of Osteoblast Differentiation Embryonic Axis Specification Neuroblast Proliferation Ventral Spinal Cord Development Hindlimb Morphogenesis
Tagcloud ?		avian codes constraints dataset desert diversification duplication evolutionary evolved genomes hedgehog helped hotspots ihh indian invertebrate invertebrates orthologs paralogous paralogs publicly reptilian shh sonic suggestions vertebrate vertebrates wgd