HDGFL3 and IL4R

		HDGFL3	IL4R
Description		HDGF like 3	interleukin 4 receptor
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GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol	Extracellular Region Nucleoplasm Plasma Membrane External Side Of Plasma Membrane Membrane Centriolar Satellite Receptor Complex
	Molecular Function	Microtubule Binding Growth Factor Activity Tubulin Binding	Cytokine Receptor Activity Interleukin-4 Receptor Activity Protein Binding
	Biological Process	Negative Regulation Of Microtubule Depolymerization Signal Transduction Neuron Projection Development Microtubule Polymerization	Immune System Process Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Immunoglobulin Production Immune Response Signal Transduction Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Positive Regulation Of Chemokine Production Interleukin-4-mediated Signaling Pathway Defense Response To Protozoan Positive Regulation Of Macrophage Activation Positive Regulation Of Mast Cell Degranulation T-helper 1 Cell Differentiation T-helper 2 Cell Differentiation Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Myoblast Fusion
Pathways			Interleukin-4 and Interleukin-13 signaling
Drugs			AER001 Dupilumab
Diseases			Asthma
GWAS			Asthma ( 34103634 32296059 31959851 31619474 31361310 30929738) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738 31036433) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Eosinophil count ( 27863252 32888494) Eosinophil percentage of white cells ( 27863252 32888494) IgE levels ( 22075330) Leprosy ( 27976721) Medication use (adrenergics, inhalants) ( 31015401) Night sleep phenotypes ( 27126917) Primary biliary cholangitis ( 28425483 26394269) Self-reported allergy ( 23817569) Serum IgE levels ( 25488688) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		4 interacting genes: H3C1 SMURF1 SMURF2 TERF2IP	23 interacting genes: ARIH2 CD40 DOK2 FES HGS IL13 IL13RA1 IL13RA2 IL2RG IL4 INPP5D IRS1 IRS2 JAK1 JAK2 JAK3 PRKCZ PTPN11 PTPN6 RACK1 SHC1 SOCS5 STAT6
Entrez ID		50810	3566
HPRD ID		17096	00990
Ensembl ID		ENSG00000166503	ENSG00000077238
Uniprot IDs		Q9Y3E1	B2RBY1 P24394
PDB IDs		6IIP 6IIQ 6IIR 6IIS 6IIT	1IAR 1IRS 3BPL 3BPN 3BPO 5E4E 6OEL 6WGL 8K4Q
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway, Planar Cell Polarity Pathway SMAD Binding Non-canonical Wnt Signaling Pathway Negative Regulation Of BMP Signaling Pathway Interleukin-4 Receptor Activity Telomere Organization Negative Regulation Of DNA Recombination At Telomere Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of BMP Signaling Pathway Engulfment Of Target By Autophagosome Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of T-helper 1 Cell Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway	Cytokine-mediated Signaling Pathway Positive Regulation Of Lymphocyte Activation Interleukin-4-mediated Signaling Pathway Regulation Of Lymphocyte Activation Positive Regulation Of Cell Activation Regulation Of Cell Activation Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Production Of Molecular Mediator Of Immune Response Regulation Of B Cell Activation Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Immunoglobulin Production Cell Surface Receptor Signaling Pathway Positive Regulation Of B Cell Activation Positive Regulation Of Immune System Process Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Immune Effector Process Regulation Of Immune System Process Regulation Of Leukocyte Proliferation Positive Regulation Of Immunoglobulin Production Regulation Of Multicellular Organismal Development Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Adaptive Immune Response Signal Transduction Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Multicellular Organismal Process Growth Hormone Receptor Signaling Pathway Via JAK-STAT Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Positive Regulation Of Developmental Process Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Cytokine Production Insulin Receptor Binding Regulation Of Lymphocyte Differentiation Growth Hormone Receptor Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of Cell-cell Adhesion Regulation Of B Cell Proliferation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Leukocyte Activation Positive Regulation Of T Cell Activation Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Regulation Of Type 2 Immune Response Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell Adhesion Regulation Of Hemopoiesis Regulation Of Macromolecule Biosynthetic Process
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