SYCP3 and PABPC1

Number of citations of the paper that reports this interaction (PMID 11591653)
37

Data Source:
HPRD (in vivo)

		SYCP3	PABPC1
Gene Name		synaptonemal complex protein 3	poly(A) binding protein, cytoplasmic 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Chromosome	Nucleus Cytoplasm Cytosol Focal Adhesion Cytoplasmic Stress Granule Membrane Ribonucleoprotein Complex Cytoplasmic Ribonucleoprotein Granule Extracellular Vesicular Exosome Catalytic Step 2 Spliceosome
	Molecular Function	DNA Binding	Nucleotide Binding Protein Binding Protein C-terminus Binding Poly(A) Binding Poly(U) RNA Binding Translation Activator Activity Poly(A) RNA Binding
	Biological Process	Male Meiosis I Spermatogenesis, Exchange Of Chromosomal Proteins Cell Division	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Splicing, Via Spliceosome MRNA Polyadenylation Translation Translational Initiation Gene Expression Gene Silencing By RNA Cellular Protein Metabolic Process Positive Regulation Of Translation MRNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Pathways		Meiotic synapsis	Translation initiation complex formation Nonsense-Mediated Decay (NMD) Regulation of mRNA stability by proteins that bind AU-rich elements Deadenylation of mRNA Translation AUF1 (hnRNP D0) destabilizes mRNA L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation-dependent mRNA decay Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: LIG4 PABPC1	43 interactors: ANAPC5 APBB1 ATXN2 CARM1 CHAF1A CNOT6 CNOT7 CSDE1 EIF4B EIF4G1 EIF4G3 GNB2L1 GSPT1 GSPT2 HBB HNRNPD HNRNPK IL7R ITCH MAPKAPK2 NDRG1 NFX1 PAIP1 PAIP2 PAIP2B PAN2 PAN3 PCBP1 PCBP2 PCSK7 PIN1 PRMT6 PXN RBM4 SREK1 STAU1 SYCP3 SYNCRIP TERT TOB1 U2AF1 WBP4 YWHAG
Entrez ID		50511	26986
HPRD ID		07265	05247
Ensembl ID		ENSG00000139351	ENSG00000070756
Uniprot IDs		Q8IZU3	E7EQV3 E7ERJ7 P11940
PDB IDs			1CVJ 1G9L 1JGN 1JH4 2K8G 2RQG 2RQH 2X04 3KTP 3KTR 3KUI 3KUJ 3KUR 3KUS 3KUT 3PKN 3PTH 4F02 4F25 4F26
Enriched GO Terms of Interacting Partners?		DNA Ligation Involved In DNA Recombination Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Lagging Strand Elongation Pro-B Cell Differentiation Establishment Of Integrated Proviral Latency Establishment Of Viral Latency Immunoglobulin V(D)J Recombination DNA Ligation Involved In DNA Repair T Cell Receptor V(D)J Recombination Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Lymphoid Progenitor Cell Differentiation DNA Ligation Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nucleotide-excision Repair, DNA Gap Filling Regulation Of MRNA 3'-end Processing Cellular Response To Lithium Ion Positive Regulation Of MRNA Catabolic Process Single Strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Stabilization Isotype Switching V(D)J Recombination DNA Strand Elongation Involved In DNA Replication MRNA Polyadenylation Response To Lithium Ion DNA Strand Elongation Response To X-ray Somatic Recombination Of Immunoglobulin Gene Segments RNA Polyadenylation Somatic Diversification Of Immunoglobulins Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response B Cell Activation Involved In Immune Response Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Response To Gamma Radiation Regulation Of MRNA Stability Regulation Of RNA Stability Neuron Apoptotic Process Immunoglobulin Production Gene Silencing By RNA Positive Regulation Of Fibroblast Proliferation Neuron Death T Cell Differentiation In Thymus Somatic Stem Cell Maintenance Positive Regulation Of Translation MRNA 3'-end Processing Regulation Of MRNA Processing Nucleotide-excision Repair Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	MRNA Metabolic Process MRNA Processing Regulation Of Translation Posttranscriptional Regulation Of Gene Expression RNA Processing Nuclear-transcribed MRNA Poly(A) Tail Shortening RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Metabolic Process MRNA 3'-end Processing Regulation Of Protein Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Gene Expression RNA 3'-end Processing Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Translational Initiation Nitrogen Compound Metabolic Process RNA Splicing Negative Regulation Of Translation Regulation Of Gene Expression MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cellular Metabolic Process Regulation Of Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Catabolic Process Viral Process Posttranscriptional Gene Silencing Regulation Of MRNA Stability Regulation Of RNA Stability Histone H3-R2 Methylation Gene Silencing By RNA Negative Regulation Of Translational Initiation Negative Regulation Of Cellular Metabolic Process Nuclear-transcribed MRNA Catabolic Process, No-go Decay Negative Regulation Of Gene Expression MRNA Stabilization Cellular Macromolecule Biosynthetic Process Negative Regulation Of Protein Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Gene Silencing Gene Silencing By MiRNA
Tagcloud ?		antigens attempted behind benign ct ctage1 ctcl cutaneous deacetylase dermatoses ectopic ectopically germ gtsf1 heterogeneously immunotherapy junb normally rec8 requirement robustly romidepsin solely spo11 sycp1 testicular testis upregulation vorinostat	address adhesion arm comprised coprecipitated cytoplasm cytoplasmic desmoplakin desmosomes destabilized fxr1 g3bp gain mrnas outside particles pkp1 pkp2 pkp3 plakophilins posttranscriptional regulators repeat ribonucleoprotein rnase serve stabilized unaffected upf1
Tagcloud (Difference) ?		antigens attempted behind benign ct ctage1 ctcl cutaneous deacetylase dermatoses ectopic ectopically germ gtsf1 heterogeneously immunotherapy junb normally rec8 requirement robustly romidepsin solely spo11 sycp1 testicular testis upregulation vorinostat	address adhesion arm comprised coprecipitated cytoplasm cytoplasmic desmoplakin desmosomes destabilized fxr1 g3bp gain mrnas outside particles pkp1 pkp2 pkp3 plakophilins posttranscriptional regulators repeat ribonucleoprotein rnase serve stabilized unaffected upf1
Tagcloud (Intersection) ?