DSG3 and PKP3

Number of citations of the paper that reports this interaction (PMID 12707304)
37

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vivo)

		DSG3	PKP3
Gene Name		desmoglein 3	plakophilin 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Membrane Desmosome Extracellular Vesicular Exosome	Nucleus Plasma Membrane Cell-cell Junction Desmosome
	Molecular Function	Calcium Ion Binding	Cell Adhesion Molecule Binding
	Biological Process	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules	Desmosome Assembly Single Organismal Cell-cell Adhesion Establishment Of Protein Localization To Plasma Membrane
Pathways		Apoptotic cleavage of cell adhesion proteins Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS		Parkinson's disease (age of onset) ( 19772629)
Protein-Protein Interactions		4 interactors: CASP3 FURIN JUP PKP3	9 interactors: DSC1 DSC2 DSC3 DSG1 DSG2 DSG3 DSP JUP KRT18
Entrez ID		1830	11187
HPRD ID		01355	05711
Ensembl ID		ENSG00000134757	ENSG00000184363
Uniprot IDs		P32926	F8J390 Q9Y446
PDB IDs
Enriched GO Terms of Interacting Partners?		Desmosome Assembly Desmosome Organization Establishment Of Protein Localization To Plasma Membrane Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Extracellular Matrix Disassembly Cell-cell Junction Assembly Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Protein Localization To Plasma Membrane Nerve Growth Factor Production Cell Junction Assembly Cell-cell Junction Organization Endothelial Cell-cell Adhesion Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Receptor Catabolic Process Neurotrophin TRK Receptor Signaling Pathway Skin Development Plasma Membrane Organization Neurotrophin Signaling Pathway Establishment Of Protein Localization To Membrane Protein Processing Nerve Growth Factor Processing Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cellular Response To Indole-3-methanol Positive Regulation Of Proteolysis Negative Regulation Of Transforming Growth Factor Beta Production Glial Cell Apoptotic Process Regulation Of Apoptotic DNA Fragmentation Bundle Of His Cell To Purkinje Myocyte Communication Protein Localization To Membrane Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Viral Protein Processing Cytoskeletal Anchoring At Plasma Membrane Cellular Response To Organic Substance Endomembrane System Organization Negative Regulation Of Activated T Cell Proliferation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Positive Regulation Of Membrane Protein Ectodomain Proteolysis Peptidyl-glutamic Acid Carboxylation Negative Regulation Of B Cell Proliferation Single Organismal Cell-cell Adhesion Signal Peptide Processing Apoptotic DNA Fragmentation Regulation Of Cell Fate Specification Ventricular Cardiac Muscle Cell Action Potential Cellular Response To Growth Factor Stimulus Platelet Formation	Bundle Of His Cell To Purkinje Myocyte Communication Ventricular Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Cardiac Conduction Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Action Potential Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Cell Adhesion Regulation Of Muscle Contraction Regulation Of Heart Contraction Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Regulation Of Membrane Potential Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Regulation Of Actin Filament-based Process Single Organismal Cell-cell Adhesion Regulation Of Cellular Component Movement Desmosome Organization Apoptotic Process Programmed Cell Death Cell Death Death Cell-cell Junction Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Response To Progesterone Golgi To Plasma Membrane CFTR Protein Transport Establishment Of Protein Localization To Plasma Membrane Maternal Process Involved In Female Pregnancy Adherens Junction Organization Protein Stabilization Ventricular Compact Myocardium Morphogenesis Cell-cell Junction Assembly Signaling Cell Communication Endothelial Cell-cell Adhesion Regulation Of Protein Stability Cellular Response To Starvation Response To Stimulus Protein Localization To Plasma Membrane Desmosome Assembly Protein Localization To Adherens Junction Cellular Response To Indole-3-methanol
Tagcloud ?		cadherins companion continuity desmocollin desmoglein desmoplakin desmosomal desmosomes displaying dsc1 dsc2 dsc3 dsg1 dsg2 exclusive follicle hair immunopositive mutually ontogenic outer plakoglobin plakophilin practically rood root sheath subinfundibular trichocytes	ankrd33b asthma beadchip cntd2 concordant cpg detrimental dpp10 enrichment epigenome fetal goal gtf2h2c gtf2h2d humanmethylation450 illumina ius lung mapped methylation methylome nicotine origins placental smoke surrogate utero variation wheezing
Tagcloud (Difference) ?		cadherins companion continuity desmocollin desmoglein desmoplakin desmosomal desmosomes displaying dsc1 dsc2 dsc3 dsg1 dsg2 exclusive follicle hair immunopositive mutually ontogenic outer plakoglobin plakophilin practically rood root sheath subinfundibular trichocytes	ankrd33b asthma beadchip cntd2 concordant cpg detrimental dpp10 enrichment epigenome fetal goal gtf2h2c gtf2h2d humanmethylation450 illumina ius lung mapped methylation methylome nicotine origins placental smoke surrogate utero variation wheezing
Tagcloud (Intersection) ?