DSG3 and PKP3

Number of citations of the paper that reports this interaction (PubMedID 12707304)
49

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vivo)

		DSG3	PKP3
Description		desmoglein 3	plakophilin 3
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Cell Junction Desmosome Extracellular Exosome Tight Junction Anchoring Junction	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Plasma Membrane Cell-cell Junction Adherens Junction Membrane Cell Junction Desmosome Anchoring Junction
	Molecular Function	Calcium Ion Binding Protein Binding Metal Ion Binding Protein Dimerization Activity	RNA Binding Protein Binding Enzyme Binding Alpha-catenin Binding Cadherin Binding Cell Adhesion Molecule Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Desmosome Assembly Actin Filament Organization Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Migration Regulation Of Protein Stability Adherens Junction Assembly Cell-cell Adhesion Tight Junction Assembly Positive Regulation Of Bicellular Tight Junction Assembly Negative Regulation Of P38MAPK Cascade Positive Regulation Of Protein Localization To Adherens Junction Positive Regulation Of Protein Localization To Membrane	Desmosome Assembly Regulation Of Cytokine Production Involved In Immune Response Desmosome Organization Regulation Of Translation Cell Adhesion Regulation Of Gene Expression Epithelial Structure Maintenance Positive Regulation Of Cell-cell Adhesion Actin Cytoskeleton Organization Positive Regulation Of Cell Adhesion Regulation Of Hair Follicle Development Protein Localization To Plasma Membrane Epithelial Cell-cell Adhesion Cell-cell Adhesion Negative Regulation Of MRNA Catabolic Process Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Protein Localization
Pathways		Apoptotic cleavage of cell adhesion proteins Keratinization Formation of the cornified envelope	Keratinization Formation of the cornified envelope
Drugs
Diseases
GWAS		Parkinson's disease (age of onset) ( 19772629) Survival in colon cancer ( 25866641)	Anorectal malformation ( 31136621) Lymphocyte count ( 32888494)
Interacting Genes		4 interacting genes: CASP3 FURIN JUP PKP3	10 interacting genes: DSC1 DSC2 DSC3 DSG1 DSG2 DSG3 DSP IQUB JUP KRT18
Entrez ID		1830	11187
HPRD ID		01355	05711
Ensembl ID		ENSG00000134757	ENSG00000184363
Uniprot IDs		P32926	Q9Y446
PDB IDs		5EQX
Enriched GO Terms of Interacting Partners?		Desmosome Assembly Alpha-catenin Binding Desmosome Organization Epithelial Cell-cell Adhesion Desmosome Cornified Envelope Endopeptidase Activity Protease Binding Gamma-catenin-TCF7L2 Complex Cell Adhesion Molecule Binding Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Regulation Of Cytokine Production Regulation Of Cell Adhesion Phospholipase A2 Activator Activity Cell-cell Junction Assembly Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Regulation Of Multicellular Organismal Process Anterior Neural Tube Closure Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Cellular Response To Staurosporine Protein Processing Protein Localization To Plasma Membrane Cell-cell Junction Organization Adherens Junction Catenin-TCF7L2 Complex Cell-cell Junction Cytoskeletal Protein-membrane Anchor Activity Endothelial Cell-cell Adhesion Viral Translation Viral Life Cycle Negative Regulation Of Receptor Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Luteolysis Glial Cell Apoptotic Process Cellular Response To Indole-3-methanol Protein Localization To Cell Periphery Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Cytokine Precursor Processing Nerve Growth Factor Binding Response To Anesthetic Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cell Junction Assembly Response To Indole-3-methanol Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process	Desmosome Cornified Envelope Desmosome Organization Cell-cell Adhesion Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Anchoring Junction Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Regulation Of Ventricular Cardiac Muscle Cell Action Potential Cell-cell Junction Organization Cell-cell Junction Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Heterotypic Cell-cell Adhesion Regulation Of Heart Rate By Cardiac Conduction Intercalated Disc Cardiac Conduction Regulation Of Action Potential Homotypic Cell-cell Adhesion Cell Junction Cell Junction Organization Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Regulation Of Heart Rate Calcium Ion Binding Positive Regulation Of Protein Localization To Cell-cell Junction Regulation Of Muscle Contraction Adherens Junction Regulation Of Heart Contraction Ficolin-1-rich Granule Membrane Regulation Of Protein Localization To Cell-cell Junction Desmosome Assembly Regulation Of Muscle System Process Regulation Of Blood Circulation Gamma-catenin Binding Extracellular Exosome Cell-cell Junction Assembly Epithelial Cell-cell Adhesion Regulation Of Actin Filament-based Process Regulation Of Membrane Potential Intermediate Filament Structural Molecule Activity Regulation Of Biological Quality Maternal Process Involved In Female Pregnancy Response To Progesterone Regulation Of System Process Regulation Of P38MAPK Cascade
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