OXA1L and CBLC

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		OXA1L	CBLC
Description		OXA1L mitochondrial inner membrane insertase	Cbl proto-oncogene C
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane Mitochondrial Membrane Protein-containing Complex	Plasma Membrane Membrane Raft
	Molecular Function	Protein Binding Membrane Insertase Activity Protein Homodimerization Activity Mitochondrial Ribosome Binding	Phosphotyrosine Residue Binding Ubiquitin-protein Transferase Activity Epidermal Growth Factor Receptor Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Transferase Activity SH3 Domain Binding Receptor Tyrosine Kinase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Aerobic Respiration Mitochondrial Translation Negative Regulation Of ATP-dependent Activity Protein Insertion Into Mitochondrial Inner Membrane From Matrix Mitochondrial Respiratory Chain Complex I Assembly Mitochondrial Proton-transporting ATP Synthase Complex Assembly Protein Tetramerization Negative Regulation Of Oxidoreductase Activity Mitochondrial Protein Quality Control	Ubiquitin-dependent Protein Catabolic Process Signal Transduction Cell Surface Receptor Signaling Pathway Protein Ubiquitination Regulation Of Signaling Protein Catabolic Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Protein Stabilization Response To Glial Cell Derived Neurotrophic Factor
Pathways		Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Complex I biogenesis Mitochondrial ribosome-associated quality control
Drugs
Diseases
GWAS		Intraocular pressure ( 30591961) Metabolite levels ( 23823483) Response to hepatitis B vaccine ( 29534301)	Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein B levels ( 32203549) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 24507774) Weight ( 28552196)
Interacting Genes		6 interacting genes: CBLC MRPL20 MRPL28 MRPL48 MRPL49 MRPL51	55 interacting genes: AKT1 BAP1 BIRC2 CCND2 CDK6 CDKN2B CHFR CKM CRK EGFR EPHA2 ERBB2 FGFR4 FYN GLIS2 GRB2 ITCH LATS2 LYN MAP2K3 MDM4 MYC NACAD NF2 NFIC NSD3 OTUD6A OXA1L RAF1 SH3GL3 SHC1 SNCA SPRY2 SRC STK11 TERT TGFB1I1 TP53 TRAF4 TRIM46 TRIP6 UBC UBE2D1 UBE2D2 UBE2D3 UBE2H UBE2I UBE2K UBE2L3 UBE2L6 UBE2R2 USP2 USP21 YES1 ZAP70
Entrez ID		5018	23624
HPRD ID		03043	09765
Ensembl ID		ENSG00000155463	ENSG00000142273
Uniprot IDs		J3KNA0 Q15070 Q2M1J6	Q9ULV8
PDB IDs		6ZM5 7A5K	3OP0 3VRN 3VRO 3VRP 3VRQ 3VRR
Enriched GO Terms of Interacting Partners?		Mitochondrial Ribosome Mitochondrial Large Ribosomal Subunit Mitochondrial Translation Ribosome Translation Ribonucleoprotein Complex Mitochondrial Inner Membrane Structural Constituent Of Ribosome Protein Metabolic Process Macromolecule Biosynthetic Process Mitochondrion Macromolecule Metabolic Process Response To Glial Cell Derived Neurotrophic Factor Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway	Transferase Activity Protein Modification Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Protein Metabolic Process Regulation Of Signal Transduction Proteolysis Regulation Of Protein Modification Process ATP Binding Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Modification Process Protein Tyrosine Kinase Activity Regulation Of MAPK Cascade Nucleotide Binding Response To Growth Factor Regulation Of Cell Communication Regulation Of Signaling Enzyme Binding Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Metabolic Process Protein Kinase Activity Cell Surface Receptor Signaling Pathway Kinase Activity Cytosol Regulation Of Protein Metabolic Process Protein Polyubiquitination Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Localization Macromolecule Catabolic Process Positive Regulation Of Phosphate Metabolic Process Protein Modification By Small Protein Conjugation Ephrin Receptor Binding Positive Regulation Of Phosphorylation Protein Ubiquitination Nucleus Cellular Response To Growth Factor Stimulus Intracellular Signal Transduction Macromolecule Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Primary Metabolic Process
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