OVGP1 and DPYD

Data Source: HiPPIP (Novel)

		OVGP1	DPYD
Name		oviductal glycoprotein 1	dihydropyrimidine dehydrogenase
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Microtubule Cytoskeleton Transport Vesicle Cytoplasmic Vesicle Egg Coat Perivitelline Space	Cytoplasm Cytosol
	Molecular Function	Chitinase Activity Chitin Binding	Nucleotide Binding Uracil Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Dihydropyrimidine Dehydrogenase (NADP+) Activity Protein Homodimerization Activity Metal Ion Binding Flavin Adenine Dinucleotide Binding NADP Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Carbohydrate Metabolic Process Chitin Catabolic Process Single Fertilization Female Pregnancy Negative Regulation Of Binding Of Sperm To Zona Pellucida	Purine Nucleobase Catabolic Process Pyrimidine Nucleobase Catabolic Process Thymine Catabolic Process Uracil Catabolic Process Thymidine Catabolic Process CMP Catabolic Process DCMP Catabolic Process Beta-alanine Biosynthetic Process UMP Catabolic Process DUMP Catabolic Process
Pathways		Interaction With Cumulus Cells And The Zona Pellucida	Pyrimidine catabolism
Drugs		None	(5S)-5-Iododihydro-2,4(1H,3H)-pyrimidinedione NADPH 6-Carboxymethyluracil Flavin adenine dinucleotide Flavin mononucleotide Uracil Eniluracil 5-Iodouracil Gimeracil Tegafur-uracil
Diseases		None	Dihydropyrimidine dehydrogenase deficiency
GWAS		Response to antidepressants (symptom improvement) ( 29160301 )	Adult body size ( 32376654 ) Adverse response to drug ( 30420678 ) Anthropometric traits (multi-trait analysis) ( 30166351 ) Anxiety/tension (special factor of neuroticism) ( 30867560 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885 ) Body mass index ( 29273807 25673413 ) Borderline personality disorder ( 28632202 ) Chronotype ( 30696823 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Coronary artery disease ( 29212778 ) Daytime nap ( 33568662 ) Extremely high intelligence ( 29520040 ) Face memory ( 31596458 ) Feeling nervous ( 29500382 ) Gastroesophageal reflux disease ( 31527586 ) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223 ) Heel bone mineral density ( 30598549 ) Household income (MTAG) ( 31844048 ) Intelligence (MTAG) ( 29326435 ) Irritable mood ( 29500382 ) Menarche (age at onset) ( 25231870 ) Metabolite levels ( 23823483 ) Methadone dose in opioid dependence ( 28115739 ) Platelet count ( 21507922 ) Regular attendance at a pub or social club ( 29970889 ) Schizophrenia ( 30285260 29483656 25056061 23974872 22688191 ) Serum metabolite levels ( 33031748 ) Sleep duration ( 30531941 ) Sleep duration (short sleep) ( 30846698 ) Triglyceride levels ( 32154731 32203549 ) Waist-to-hip ratio adjusted for BMI ( 28552196 )
Novel Interactors		1 novel interactors: DPYD	8 novel interactors: CPB2 CSDE1 HPCA KCNJ4 OVGP1 RPS6KA3 SRC SULT2A1
Interacting Genes		4 interacting genes: ASL MYH9 RASA4 STATH	3 interacting genes: CLK1 GOPC LXN
Entrez ID		5016	1806
HPRD ID		04658	02036
Ensembl ID		ENSG00000085465	ENSG00000188641
Uniprot IDs		Q12889 Q86YN0	Q12882
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		L-arginine Biosynthetic Process Via Ornithine Argininosuccinate Lyase Activity Amino Acid Biosynthetic Process Nitrogen Utilization Ammonia Assimilation Cycle Uracil Binding Beta-alanine Metabolic Process Thymidine Catabolic Process Uracil Catabolic Process Beta-alanine Biosynthetic Process Dihydropyrimidine Dehydrogenase (NADP+) Activity Uropod Organization Cortical Granule Exocytosis Negative Regulation Of Actin Filament Severing Positive Regulation Of Protein Processing In Phagocytic Vesicle Extracellular Matrix Constituent, Lubricant Activity Pyrimidine Nucleoside Catabolic Process Thymine Metabolic Process Thymine Catabolic Process Purine Nucleobase Catabolic Process Myosin II Filament L-arginine Biosynthetic Process CMP Catabolic Process DUMP Catabolic Process Actomyosin Contractile Ring Structural Constituent Of Tooth Enamel Hydroxyapatite Binding DCMP Catabolic Process UMP Catabolic Process Cortical Granule Cytoplasmic Actin-based Contraction Involved In Cell Motility Deoxyribonucleoside Catabolic Process Saliva Secretion Amino Acid Metabolic Process Carboxylic Acid Biosynthetic Process Thymidine Metabolic Process Pyrimidine Nucleobase Catabolic Process Pyrimidine Ribonucleotide Catabolic Process Regulation Of Plasma Membrane Repair Establishment Of Meiotic Spindle Localization Establishment Of T Cell Polarity Actomyosin Supramolecular Fiber Urea Cycle Urea Metabolic Process Nitrogen Cycle Metabolic Process Pyrimidine Nucleoside Metabolic Process Nucleobase-containing Small Molecule Catabolic Process Deoxyribonucleoside Monophosphate Catabolic Process Uropod	None