RDH5 and RGR

Number of citations of the paper that reports this interaction (PubMedID 11274198)
0

Data Source:
HPRD (in vivo)

		RDH5	RGR
Description		retinol dehydrogenase 5	retinal G protein coupled receptor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle Cell Body	Plasma Membrane Membrane
	Molecular Function	All-trans-retinol Dehydrogenase (NAD+) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Homodimerization Activity Androsterone Dehydrogenase [NAD(P)+] Activity Androstan-3-alpha,17-beta-diol Dehydrogenase (NAD+) Activity 11-cis-retinol Dehydrogenase (NAD+) Activity	G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Photoreceptor Activity Photoreceptor Activity
	Biological Process	Retinoid Metabolic Process Lipid Metabolic Process Visual Perception Steroid Metabolic Process Retinol Metabolic Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Visual Perception Phototransduction Detection Of Visible Light Cellular Response To Light Stimulus
Pathways		The canonical retinoid cycle in rods (twilight vision) RA biosynthesis pathway Defective visual phototransduction due to RDH5 loss of function	G alpha (i) signalling events Opsins
Drugs		NADH Vitamin A
Diseases		Familial flecked retina syndrome, including: Doyne honeycomb degeneration of retina (DHRD); Basal laminar drusen (BLD); Fundus albipunctatus (FA); Retinitis punctata albescens (RPA); Bietti crystalline corneoretinal dystrophy (BCD)	Retinitis pigmentosa (RP)
GWAS		Advanced age-related macular degeneration ( 26691988) High myopia ( 31816047) Macular thickness ( 30535121) Myopia ( 27182965) Refractive error ( 23396134) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	High myopia ( 31816047) Myopia ( 27182965) Refractive error ( 32231278)
Interacting Genes		3 interacting genes: ORC4 RGR RLBP1	7 interacting genes: ADRB2 CCR2 F2RL1 KIFBP RDH5 TRIM55 TRIM63
Entrez ID		5959	5995
HPRD ID		03370	02642
Ensembl ID		ENSG00000135437	ENSG00000148604
Uniprot IDs		Q92781	A0A0S2Z494 A0A0S2Z498 P47804
PDB IDs
Enriched GO Terms of Interacting Partners?		P450-containing Electron Transport Chain Negative Regulation Of Transcription By RNA Polymerase III Schwann Cell Differentiation Nuclear Origin Of Replication Recognition Complex Meiotic Cytokinesis Origin Recognition Complex Polar Body Extrusion After Meiotic Divisions Visual Perception Sensory Perception Of Light Stimulus Vitamin A Metabolic Process 11-cis Retinal Binding Photoreceptor Activity G Protein-coupled Photoreceptor Activity Phosphatidylinositol Bisphosphate Binding Retinol Binding Cellular Response To Forskolin DNA Replication Origin Binding Response To Forskolin	Macrophage Migration Vasodilation Positive Regulation Of Protein-containing Complex Disassembly G Protein-coupled Receptor Activity Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Mini Excitatory Postsynaptic Potential System Process Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Type II Interferon Production Leukocyte Migration Positive Regulation Of Renin Secretion Into Blood Stream 11-cis-retinol Dehydrogenase (NAD+) Activity Negative Regulation Of Eosinophil Degranulation Positive Regulation Of Astrocyte Chemotaxis T-helper 17 Cell Chemotaxis Chemokine (C-C Motif) Ligand 12 Binding Chemokine (C-C Motif) Ligand 2 Binding Beta2-adrenergic Receptor Activity Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Cold-induced Thermogenesis Proteinase-activated Receptor Activity Immune Response Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Eosinophil Degranulation Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Mononuclear Cell Migration Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Positive Regulation Of Thymocyte Migration Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Chemokine (C-C Motif) Ligand 7 Binding Positive Regulation Of Hematopoietic Stem Cell Migration Regulation Of Astrocyte Chemotaxis Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Regulation Of System Process Regulation Of Protein-containing Complex Disassembly Regulation Of Cytokine Production Involved In Immune Response Regulation Of Regulated Secretory Pathway Regulation Of Type II Interferon Production Positive Regulation Of Glomerular Filtration Defense Response Regulation Of Renin Secretion Into Blood Stream Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Myeloid Leukocyte Migration Regulation Of Thymocyte Migration Regulation Of Immune Complex Clearance By Monocytes And Macrophages Blood Vessel Diameter Maintenance Norepinephrine Binding
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