RDH5

Description		retinol dehydrogenase 5
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle Cell Body
	Molecular Function	All-trans-retinol Dehydrogenase (NAD+) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Homodimerization Activity Androsterone Dehydrogenase [NAD(P)+] Activity Androstan-3-alpha,17-beta-diol Dehydrogenase (NAD+) Activity 11-cis-retinol Dehydrogenase (NAD+) Activity
	Biological Process	Retinoid Metabolic Process Lipid Metabolic Process Visual Perception Steroid Metabolic Process Retinol Metabolic Process
Pathways		The canonical retinoid cycle in rods (twilight vision) RA biosynthesis pathway Defective visual phototransduction due to RDH5 loss of function
Drugs		NADH Vitamin A
Diseases		Familial flecked retina syndrome, including: Doyne honeycomb degeneration of retina (DHRD); Basal laminar drusen (BLD); Fundus albipunctatus (FA); Retinitis punctata albescens (RPA); Bietti crystalline corneoretinal dystrophy (BCD)
GWAS		Advanced age-related macular degeneration ( 26691988) High myopia ( 31816047) Macular thickness ( 30535121) Myopia ( 27182965) Refractive error ( 23396134) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Novel Interacting Genes		2 novel interacting genes: FDX1 NAB2
Interacting Genes		3 interacting genes: ORC4 RGR RLBP1
Entrez ID		5959
HPRD ID		03370
Ensembl ID		ENSG00000135437
Uniprot IDs		Q92781
PDB IDs
Enriched GO Terms of Interacting Partners?		P450-containing Electron Transport Chain Negative Regulation Of Transcription By RNA Polymerase III Schwann Cell Differentiation Nuclear Origin Of Replication Recognition Complex Meiotic Cytokinesis Origin Recognition Complex Polar Body Extrusion After Meiotic Divisions Visual Perception Sensory Perception Of Light Stimulus Vitamin A Metabolic Process 11-cis Retinal Binding Photoreceptor Activity G Protein-coupled Photoreceptor Activity Phosphatidylinositol Bisphosphate Binding Retinol Binding Cellular Response To Forskolin DNA Replication Origin Binding Response To Forskolin
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