CERS6

Description		ceramide synthase 6
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	DNA Binding Protein Binding Transferase Activity Sphingosine N-acyltransferase Activity
	Biological Process	Lipid Metabolic Process Sphingolipid Metabolic Process Inflammatory Response Oligodendrocyte Development Sphingolipid Biosynthetic Process Ceramide Biosynthetic Process Positive Regulation Of Oligodendrocyte Apoptotic Process
Pathways		Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756 34002096) Parkinson's disease ( 27182965) Recurrent major depressive disorder ( 34099189) Recurrent major depressive disorder x sex interaction ( 34099189) Red cell distribution width ( 27863252 28957414 32888494) Skin aging (microtopography measurement) ( 28502801) Thyroid stimulating hormone levels ( 32769997) Triglyceride levels ( 32203549)
Interacting Genes		5 interacting genes: AGTR1 BCL2L13 CERS2 OPRL1 SEC22B
Entrez ID		253782
HPRD ID		17258
Ensembl ID		ENSG00000172292
Uniprot IDs		Q6ZMG9
PDB IDs		8QZ6 8QZ7 9EOT
Enriched GO Terms of Interacting Partners?		Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Calcium-mediated Signaling Angiotensin Type I Receptor Activity Phospholipase C-activating Angiotensin-activated Signaling Pathway Bradykinin Receptor Binding Renin-angiotensin Regulation Of Aldosterone Production Nociceptin Receptor Activity Negative Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration Negative Regulation Of Schwann Cell Migration Angiotensin Type II Receptor Activity Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin G Protein-coupled Opioid Receptor Activity Negative Regulation Of Glial Cell Migration Sphingosine N-acyltransferase Activity Regulation Of Lipid Metabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Renal Sodium Excretion Neuron-neuron Synaptic Transmission G Protein-coupled Opioid Receptor Signaling Pathway Negative Regulation Of Autophagosome Assembly Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Negative Regulation Of Axon Regeneration Negative Regulation Of Schwann Cell Proliferation N-acyltransferase Activity Negative Regulation Of Neuron Projection Regeneration G Protein-coupled Receptor Activity Low-density Lipoprotein Particle Remodeling Positive Regulation Of Macrophage Derived Foam Cell Differentiation Angiotensin-activated Signaling Pathway Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Glycolytic Process Through Glucose-6-phosphate Oxidative Phosphorylation Glycolytic Process Through Fructose-6-phosphate Canonical Glycolysis Negative Regulation Of Glial Cell Proliferation Regulation Of Glial Cell Migration
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