NVL and NDUFAF1

		NVL	NDUFAF1
Description		nuclear VCP like	NADH:ubiquinone oxidoreductase complex assembly factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Nucleus Nucleoplasm Telomerase Holoenzyme Complex Nucleolus Membrane	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytosol
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Protein-containing Complex Binding Preribosome Binding	Protein Binding Unfolded Protein Binding
	Biological Process	RRNA Processing Positive Regulation Of Protein Binding Positive Regulation Of Telomere Maintenance Ribosome Biogenesis Ribosomal Large Subunit Biogenesis Regulation Of Protein Localization To Nucleolus Telomerase Holoenzyme Complex Assembly	Mitochondrial Electron Transport, NADH To Ubiquinone Mitochondrial Respiratory Chain Complex I Assembly Chaperone-mediated Protein Complex Assembly Protein-containing Complex Assembly
Pathways			Complex I biogenesis
Drugs
Diseases
GWAS		HDL cholesterol levels in HIV infection ( 33109212) Major depressive disorder ( 21042317) Mean corpuscular hemoglobin ( 32888494)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Eosinophil percentage of white cells ( 27863252) Ulcerative colitis ( 23128233 28067908)
Interacting Genes		11 interacting genes: ADARB1 CRMP1 FBXO7 HSPB1 LINC00839 OSGEP RNF10 RNF4 RPL5 TTF2 UBE2I	7 interacting genes: MAGEA11 PNLIPRP1 SLC30A2 STX8 TMEM86B TMEM97 YIPF6
Entrez ID		4931	51103
HPRD ID		03887	09500
Ensembl ID		ENSG00000143748	ENSG00000137806
Uniprot IDs		B4DF43 O15381	Q9Y375
PDB IDs		2X8A 6RO1
Enriched GO Terms of Interacting Partners?		Hypoglossal Nerve Morphogenesis Negative Regulation Of Protein Kinase C Signaling Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process SUMO Conjugating Enzyme Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Autoubiquitination Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Double-stranded RNA Adenosine Deaminase Activity Cytoplasm Adenosine To Inosine Editing RNA Processing Spinal Cord Ventral Commissure Morphogenesis Facial Nerve Morphogenesis Cytosol Regulation Of Protein Kinase C Signaling Unfolded Protein Binding Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Protein Kinase C Inhibitor Activity Ubiquitin Binding Regulation Of Kinetochore Assembly Post-translational Protein Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process SUMO Polymer Binding Protein K48-linked Ubiquitination PML Body Cytosolic Ribosome Negative Regulation Of Protein Neddylation RING-like Zinc Finger Domain Binding SUMO Ligase Complex Small Protein Activating Enzyme Binding HLH Domain Binding Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Lewy Body Core EKC/KEOPS Complex TRNA N(6)-L-threonylcarbamoyladenine Synthase Activity TRNA Threonylcarbamoyladenosine Modification TRNA-specific Adenosine Deaminase Activity Dihydropyrimidinase Activity Regulation Of Centromere Complex Assembly Proteasomal Protein Catabolic Process Negative Regulation Of Protein Localization To Chromatin	Zinc Ion Import Into Lysosome Zinc Export Across Plasma Membrane Vacuolar Transmembrane Transport Zinc Ion Import Into Organelle Monoatomic Cation Transmembrane Transporter Activity Zinc Ion Transport Zinc Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transport Late Endosome Response To Zinc Ion Zinc Ion Import Into Zymogen Granule Export Across Plasma Membrane Zinc Ion Import Into Mitochondrion Zinc Ion Import Into Secretory Vesicle D-lysine 5,6-aminomutase Activity Sterol Homeostasis Cholesterol Homeostasis Ether Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity Antiporter Activity Lysosomal Transport Lysosome Zinc:proton Antiporter Activity Positive Regulation Of Lipoprotein Transport Telomerase Holoenzyme Complex Assembly Intracellular Transport Preribosome Binding Lipoprotein Lipase Activity Lipid Homeostasis Vacuolar Transport Secretory Vesicle Chloride Channel Inhibitor Activity Trans-Golgi Network Rough Endoplasmic Reticulum Membrane Regulation Of Intracellular Cholesterol Transport Regulation Of Intracellular Lipid Transport Golgi Trans Cisterna Golgi Medial Cisterna Positive Regulation Of Protein Binding Intestinal Epithelial Cell Development Regulation Of Protein Localization To Nucleolus
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