NDUFAF1 and TMEM86B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NDUFAF1	TMEM86B
Description		NADH:ubiquinone oxidoreductase complex assembly factor 1	transmembrane protein 86B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytosol	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Unfolded Protein Binding	Protein Binding Hydrolase Activity Ether Hydrolase Activity Identical Protein Binding Alkenylglycerophosphocholine Hydrolase Activity D-lysine 5,6-aminomutase Activity
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Mitochondrial Respiratory Chain Complex I Assembly Chaperone-mediated Protein Complex Assembly Protein-containing Complex Assembly	Lipid Metabolic Process Phosphatidylcholine Acyl-chain Remodeling Ether Lipid Metabolic Process
Pathways		Complex I biogenesis	Acyl chain remodelling of PC
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Eosinophil percentage of white cells ( 27863252) Ulcerative colitis ( 23128233 28067908)	Mean reticulocyte volume ( 32888494) Phosphatidylethanolamine-ether levels ( 31551469) Serum metabolite levels ( 33031748) Systemic lupus erythematosus ( 28714469 33536424)
Interacting Genes		7 interacting genes: MAGEA11 PNLIPRP1 SLC30A2 STX8 TMEM86B TMEM97 YIPF6	106 interacting genes: AQP6 ARL13B ARL6IP6 ASGR2 BCL2L13 BIK BMP10 C2CD2L CCDC167 CCDC34 CCL4 CD53 CD79A CLRN1 CYB5B DHRSX DNAJC30 EBP ERGIC3 ERP29 EVI2B F11R FAM209A FAXDC2 FFAR2 FKBP7 FXYD6 GJA1 GJA4 GJA8 GOLM1 GPR37L1 GPX8 GUCA2A HIBADH HSD17B13 IER3IP1 IFITM3 KIR2DL3 LAPTM4B LIME1 LSS LY6D MARCHF2 MFF MGST3 MMGT1 MS4A14 MSMO1 MUC1 NDUFAF1 NEMP1 NINJ2 ORMDL2 OTULINL PEX11G PGRMC2 PIGF PLN PSCA PTPN1 PTPN9 RHBDD1 RHOT2 RPRM RTP2 SEC22B SERINC2 SFRP1 SFT2D1 SFXN5 SLC10A6 SLC29A2 SLC35G2 SLC39A9 SMIM1 SNORC SSMEM1 STOM STX12 STX6 STX8 TEX29 THAP4 THBD TIMM23 TMEM106A TMEM107 TMEM120A TMEM14A TMEM14C TMEM203 TMEM237 TMEM248 TMEM52B TMEM60 TMPRSS2 TMX2 TREX1 TSNARE1 USE1 VAMP2 VAMP3 VAMP5 VAPA ZDHHC22
Entrez ID		51103	255043
HPRD ID		09500	14540
Ensembl ID		ENSG00000137806	ENSG00000180089
Uniprot IDs		Q9Y375	Q8N661
PDB IDs
Enriched GO Terms of Interacting Partners?		Zinc Ion Import Into Lysosome Zinc Export Across Plasma Membrane Vacuolar Transmembrane Transport Zinc Ion Import Into Organelle Monoatomic Cation Transmembrane Transporter Activity Zinc Ion Transport Zinc Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transport Late Endosome Response To Zinc Ion Zinc Ion Import Into Zymogen Granule Export Across Plasma Membrane Zinc Ion Import Into Mitochondrion Zinc Ion Import Into Secretory Vesicle D-lysine 5,6-aminomutase Activity Sterol Homeostasis Cholesterol Homeostasis Ether Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity Antiporter Activity Lysosomal Transport Lysosome Zinc:proton Antiporter Activity Positive Regulation Of Lipoprotein Transport Telomerase Holoenzyme Complex Assembly Intracellular Transport Preribosome Binding Lipoprotein Lipase Activity Lipid Homeostasis Vacuolar Transport Secretory Vesicle Chloride Channel Inhibitor Activity Trans-Golgi Network Rough Endoplasmic Reticulum Membrane Regulation Of Intracellular Cholesterol Transport Regulation Of Intracellular Lipid Transport Golgi Trans Cisterna Golgi Medial Cisterna Positive Regulation Of Protein Binding Intestinal Epithelial Cell Development Regulation Of Protein Localization To Nucleolus	Membrane SNAP Receptor Activity Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNARE Complex Protein Binding Membrane Fusion Mitochondrial Membrane Endomembrane System Plasma Membrane Organelle Localization By Membrane Tethering Membrane Organization Cellular Localization Vesicle Membrane Docking Vesicle Fusion Vesicle Docking Organelle Membrane Fusion SNARE Binding Golgi Vesicle Transport C-4 Methylsterol Oxidase Activity Sterol Biosynthetic Process Vesicle Organization Organelle Fusion Connexin Complex B Cell Receptor Complex Gap Junction Channel Activity Nuclear Inner Membrane Localization Within Membrane Gap Junction
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