DOK6 and METTL27

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		DOK6	METTL27
Name		docking protein 6	methyltransferase like 27
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	None
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway	None
Pathways		RET signaling	None
GWAS		Bone fracture in osteoporosis ( 28580392 ) Caudate activity during reward ( 28927378 ) Mean platelet volume ( 31194788 ) Neonatal total 25-hydroxyvitamin D levels (maternal genetic effect) ( 32047095 ) Osteoporosis-related phenotypes ( 20548944 ) Platelet distribution width ( 32888494 ) Pursuit maintenance gain ( 29064472 ) Response to cytidine analogues (gemcitabine) ( 24483146 ) Skin aging (microtopography measurement) ( 28502801 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: CD226	None recorded
Interacting Genes		20 interacting genes: ABHD11 ARID5A C1orf94 CRYBB3 EGFR ERBB2 FAM86C1P LASP1 LGALS14 METTL27 NTRK3 PRR22 RBPMS RET RUSC1 SLC30A6 TBX15 TLE5 USP54 YPEL3	29 interacting genes: A1CF ATXN1 ATXN1L CCDC120 CSTF2 DOK6 EFHC1 ENKD1 FOXC2 GLYCTK GPANK1 GRB2 HGS KDM1A LMO4 NOXA1 PITX1 PRKAB2 PRMT6 PROP1 SAXO4 SNRPC TBX6 TEKT3 TFG TLX3 VPS37C ZIC1 ZNF77
Entrez ID		220164	155368
HPRD ID		13244	15661
Ensembl ID		ENSG00000206052	ENSG00000165171
Uniprot IDs		Q6PKX4	Q8N6F8
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity ERBB2-EGFR Signaling Pathway Receptor Complex	POZ Domain Binding Axonemal A Tubule Inner Sheath Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Sequence-specific Double-stranded DNA Binding Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway