MATK and HSPA5

Number of citations of the paper that reports this interaction (PubMedID 19299420)
73

Data Source:
BioGRID (pull down)

		MATK	HSPA5
Description		megakaryocyte-associated tyrosine kinase	heat shock protein family A (Hsp70) member 5
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane Focal Adhesion COP9 Signalosome Cell Surface Membrane Midbody Protein-containing Complex Endoplasmic Reticulum Chaperone Complex Melanosome Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity	Nucleotide Binding Calcium Ion Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Enzyme Binding Protein Domain Specific Binding Protein Serine/threonine Kinase Inhibitor Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Ribosome Binding Protein Folding Chaperone Cadherin Binding Unfolded Protein Binding Protein-folding Chaperone Binding Misfolded Protein Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Protein Phosphorylation Positive Regulation Of Cell Population Proliferation	Translational Initiation Protein Folding ER Overload Response Cerebellum Structural Organization Cerebellar Purkinje Cell Layer Development Substantia Nigra Development Positive Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Post-translational Protein Targeting To Membrane, Translocation Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Ubiquitination Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Maintenance Of Protein Localization In Endoplasmic Reticulum IRE1-mediated Unfolded Protein Response PERK-mediated Unfolded Protein Response ERAD Pathway Protein Refolding Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Folding In Endoplasmic Reticulum Cellular Response To Interleukin-4 Regulation Of ATF6-mediated Unfolded Protein Response Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of PERK-mediated Unfolded Protein Response Negative Regulation Of PERK-mediated Unfolded Protein Response
Pathways		Downregulation of ERBB2 signaling	Platelet degranulation Regulation of HSF1-mediated heat shock response ATF6 (ATF6-alpha) activates chaperones PERK regulates gene expression IRE1alpha activates chaperones ATF6 (ATF6-alpha) activates chaperone genes ATF6B (ATF6-beta) activates chaperones Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC Modulation of host responses by IFN-stimulated genes
Drugs		Fostamatinib	Antihemophilic factor, human recombinant Acetylsalicylic acid Copper Lonoctocog alfa Moroctocog alfa
Diseases
GWAS		Obesity-related traits ( 23251661)	Refractive error ( 32231278) Smoking initiation ( 33082346)
Interacting Genes		24 interacting genes: AKT1 AR CACNA1A CD36 ERBB2 ERBB3 ERBB4 EWSR1 FRS3 HSPA5 HSPA9 ILK KIT LRRK1 LRRK2 LYN MET NTRK1 PTK2B PTPRD PXN SIRPA SMURF1 SRC	77 interacting genes: A2M AGO4 APC APOB BAG3 BCAR1 CASP7 CDK7 CPT1A DDX24 DNAJC1 DNAJC10 DPH1 DPYSL5 EIF2AK3 ERBB2 ERCC6 ERN1 ERP29 F8 FCHSD2 FNDC3B GRIA1 HLA-C HMGB1 HSPBP1 HTR3A IGHM KRT14 KRT18 KRT8 LCT LDLR LINC01554 MATK METTL21A MTNR1A MTNR1B NDRG1 NEDD4L NRIP1 OTUD3 PARK7 PAWR PCSK7 PRDM14 PRNP PSME3 PTPN11 PTPRF RIPK4 RNF114 RNF26 RPN1 SEC61A1 SEC63 SERPINB5 SH3BP4 SIL1 SIRPA SQSTM1 SREBF2 STMN1 SUMO2 SUMO4 TCERG1 TG TMEM132A TMEM62 TRA TSHR UBE3A UBQLN4 VHL VWF XAF1 YWHAB
Entrez ID		4145	3309
HPRD ID		02496	00682
Ensembl ID		ENSG00000007264	ENSG00000044574
Uniprot IDs		F1T0G6 P42679	P11021 V9HWB4
PDB IDs		1JWO 1X6G 3US4	3IUC 3LDL 3LDN 3LDO 3LDP 5E84 5E85 5E86 5EVZ 5EX5 5EXW 5EY4 5F0X 5F1X 5F2R 6ASY 6CZ1 6DFM 6DFO 6DO2 6DWS 6ZMD 7N1R
Enriched GO Terms of Interacting Partners?		Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Kinase Activity Protein Tyrosine Kinase Activity Negative Regulation Of Programmed Cell Death Protein Autophosphorylation Cell Surface Receptor Signaling Pathway Kinase Activity Positive Regulation Of MAPK Cascade Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Regulation Of MAPK Cascade Regulation Of Signal Transduction Peptidyl-tyrosine Phosphorylation ATP Binding Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Epidermal Growth Factor Receptor Signaling Pathway Protein Phosphorylation ERBB Signaling Pathway Nucleotide Binding Phosphorylation Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Signal Transduction Receptor Complex Positive Regulation Of Developmental Process Transmembrane Receptor Protein Tyrosine Kinase Activity Negative Regulation Of Apoptotic Process Cell Differentiation Positive Regulation Of Multicellular Organismal Process Cellular Response To Oxygen-containing Compound Regulation Of Developmental Process Positive Regulation Of Cellular Component Biogenesis Signal Transduction ERBB2 Signaling Pathway Positive Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Cellular Developmental Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Protein Modification Process Positive Regulation Of Phosphorylation Positive Regulation Of Protein Metabolic Process Signal Complex Assembly Signaling Receptor Activator Activity Regulation Of Protein Modification Process Regulation Of Anatomical Structure Morphogenesis	Macromolecule Catabolic Process Regulation Of Protein Localization Endoplasmic Reticulum Protein Metabolic Process Regulation Of Establishment Of Protein Localization Positive Regulation Of Catabolic Process Catabolic Process Protein-folding Chaperone Binding Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Modification-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Autophagy Negative Regulation Of Establishment Of Protein Localization Adenyl-nucleotide Exchange Factor Activity Cotranslational Protein Targeting To Membrane Molecular Sequestering Activity Proteolysis Protein Modification Process Negative Regulation Of Signaling Regulation Of Protein Metabolic Process Negative Regulation Of Metabolic Process Melatonin Receptor Activity Regulation Of Metabolic Process Negative Regulation Of Transport Response To Stress Regulation Of Protein Transport Regulation Of Apoptotic Process Cellular Response To Stress Regulation Of Signal Transduction Signal Transduction Immunoglobulin Binding Cupric Ion Binding Negative Regulation Of Protein Transport Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Leukocyte Activation Scaffold Protein Binding Regulation Of Type I Interferon Production Regulation Of Proteolysis Protein Folding Positive Regulation Of Transcription By RNA Polymerase I Negative Regulation Of T Cell Proliferation Positive Regulation Of Cholesterol Storage Negative Regulation Of T Cell Activation Ubiquitin-like Protein Conjugating Enzyme Binding
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