ATP2B1 and DAO

Data Source: HiPPIP (Novel)

		ATP2B1	DAO
Name		ATPase plasma membrane Ca2+ transporting 1	D-amino acid oxidase
Structure
GO Annotations	Cellular Component	Immunological Synapse Nucleoplasm Plasma Membrane Membrane Basolateral Plasma Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Intracellular Membrane-bounded Organelle Synapse Extracellular Exosome Photoreceptor Ribbon Synapse Glutamatergic Synapse	Extracellular Region Extracellular Space Cytoplasm Mitochondrial Outer Membrane Peroxisome Peroxisomal Matrix Cytosol Cell Projection Synapse Presynaptic Active Zone
	Molecular Function	Nucleotide Binding P-type Calcium Transporter Activity Protein Binding Calmodulin Binding ATP Binding Calcium Ion Transmembrane Transporter Activity ATP Hydrolysis Activity Metal Ion Binding Molecular Function Inhibitor Activity	D-amino-acid Oxidase Activity Protein Binding D-amino-acid Dehydrogenase Activity Oxidoreductase Activity Identical Protein Binding Glycine Oxidase Activity FAD Binding
	Biological Process	Negative Regulation Of Cytokine Production Regulation Of Vascular Associated Smooth Muscle Contraction Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Regulation Of Blood Pressure Positive Regulation Of Bone Mineralization Monoatomic Ion Transmembrane Transport Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Calcium Ion Transport Calcium Ion Transmembrane Transport Regulation Of Cellular Response To Insulin Stimulus Regulation Of Cardiac Conduction Calcium Ion Export Across Plasma Membrane	L-leucine Metabolic Process L-proline Catabolic Process Digestion D-amino Acid Catabolic Process D-serine Catabolic Process Dopamine Biosynthetic Process D-amino Acid Metabolic Process Killing By Host Of Symbiont Cells D-alanine Catabolic Process D-serine Metabolic Process Neutrophil-mediated Killing Of Gram-negative Bacterium L-amino Acid Catabolic Process Proteinogenic Amino Acid Catabolic Process
Pathways		Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases Sensory processing of sound by inner hair cells of the cochlea	Glyoxylate metabolism and glycine degradation Peroxisomal protein import Peroxisomal protein import
Drugs		Ritodrine Halothane Desflurane Sevoflurane	3,4-Dihydro-2h-Pyrrolium-5-Carboxylate Imino-Tryptophan Flavin adenine dinucleotide D-Tryptophan Flavin-adenine dinucleotide-N5-isobutyl ketone Benzoic acid Anthranilic acid (2E)-3-(3,4-DIHYDROXYPHENYL)-2-IMINOPROPANOIC ACID
GWAS		Adult body size ( 32376654 ) Automobile speeding propensity ( 30643258 ) Biomedical quantitative traits ( 19396169 ) Blood pressure ( 21572416 21909110 24001895 24954895 ) Calcium levels ( 29403010 ) Chronotype ( 30696823 ) Coronary artery disease ( 29212778 32469254 26343387 33020668 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) Coronary heart disease ( 22751097 ) Diastolic blood pressure ( 25249183 28739976 26390057 29403010 30487518 27841878 27618452 19430479 ) Diastolic blood pressure (cigarette smoking interaction) ( 29455858 ) Diastolic blood pressure (long-term average) ( 28348047 ) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962 ) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Diffusing capacity of carbon monoxide ( 30694715 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Hypertension ( 30487518 31879980 32709000 31513605 28273873 25249183 19430479 ) Lumbar spine bone mineral density (integral) ( 27476799 ) Lumbar spine bone mineral density (trabecular) ( 27476799 ) Magnesium levels ( 20700443 ) Mean arterial pressure ( 30487518 29403010 26390057 27618448 ) Mean arterial pressure (long-term average) ( 28348047 ) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962 ) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962 ) Medication use (calcium channel blockers) ( 31015401 ) Medication use (diuretics) ( 31015401 ) Morning person ( 30696823 ) Myocardial infarction ( 33532862 26343387 ) Nonobstructive coronary artery disease ( 26534935 ) Pulse pressure ( 29403010 26390057 27841878 30578418 30487518 28739976 ) Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962 ) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Systolic blood pressure ( 28739976 29403010 19430479 25249183 26390057 27618447 27618452 30578418 30487518 30224653 27841878 ) Systolic blood pressure (cigarette smoking interaction) ( 29455858 ) Systolic blood pressure (long-term average) ( 28348047 ) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962 ) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Total body bone mineral density ( 29304378 )	Brain morphology (MOSTest) ( 32665545 ) Mean platelet volume ( 32888494 ) Nicotine dependence and major depression (severity of comorbidity) ( 30287806 )
Novel Interactors		2 novel interactors: DAO TRIM32	5 novel interactors: ATP2B1 CCAR1 FBXO21 PRDM4 UNG
Interacting Genes		7 interacting genes: CALM1 CCR2 CSNK2A1 ERBIN F2RL1 PRKACA PRKCA	5 interacting genes: AOC1 DAOA EP300 PEX5 PRKAB2
Entrez ID		490	1610
HPRD ID		00158	15917
Ensembl ID		ENSG00000070961	ENSG00000110887
Uniprot IDs		P20020	A0A024RBI1 A0A0S2Z3J4 P14920
PDB IDs		6A69	2DU8 2E48 2E49 2E4A 2E82 3CUK 3G3E 3W4I 3W4J 3W4K 3ZNN 3ZNO 3ZNP 3ZNQ 4QFC 4QFD 5ZJ9 5ZJA 6KBP 7U9S 7U9U 8HY5
GO Terms Enriched among Interactors		Regulation Of Cytokine Production Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Response To Peptide Response To Cytokine Positive Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Intracellular Signal Transduction Regulation Of Chemokine Production Negative Regulation Of Cytokine Production Renal System Process Regulation Of Biological Quality Positive Regulation Of Protein Secretion Regulation Of Multicellular Organismal Process Calcium-mediated Signaling Signal Transduction Calcium Channel Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of System Process Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Cell Cycle Regulation Of Macroautophagy Negative Regulation Of Gene Expression Regulation Of Peptide Hormone Secretion Negative Regulation Of Immune System Process Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Cytokine Production Regulation Of Insulin Secretion Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Vesicle-mediated Transport Regulation Of Exocytosis Negative Regulation Of Chemokine Production Regulation Of Secretion By Cell Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Positive Regulation Of Locomotion Response To Stress Regulation Of Secretion Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Muscle System Process Positive Regulation Of Protein Transport Regulation Of Hormone Secretion Regulation Of Protein Secretion Sperm Midpiece	Diamine Oxidase Activity Putrescine Oxidase Activity Histamine Oxidase Activity Peptidyl-lysine Propionylation Carboxylic Acid Metabolic Process Swimming Histone Lactyltransferase (CoA-dependent) Activity Organic Acid Metabolic Process Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Damaged DNA Binding Small Molecule Metabolic Process Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Thigmotaxis Nucleotide Catabolic Process Peptide Lactyltransferase (CoA-dependent) Activity Peroxisome Targeting Sequence Binding Peroxisome Monocarboxylic Acid Metabolic Process Negative Regulation Of Protein Oligomerization Nucleoside Phosphate Catabolic Process Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Uracil DNA N-glycosylase Activity D-amino Acid Metabolic Process