DAO and FBXO21

		DAO	FBXO21
Description		D-amino acid oxidase	F-box protein 21
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Mitochondrial Outer Membrane Peroxisome Peroxisomal Matrix Cytosol Cell Projection Synapse Presynaptic Active Zone	Ubiquitin Ligase Complex Cytosol
	Molecular Function	D-amino-acid Oxidase Activity Protein Binding D-amino-acid Dehydrogenase Activity Oxidoreductase Activity Identical Protein Binding Glycine Oxidase Activity FAD Binding	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	L-leucine Metabolic Process L-proline Catabolic Process Digestion D-amino Acid Catabolic Process D-serine Catabolic Process Dopamine Biosynthetic Process D-amino Acid Metabolic Process Killing By Host Of Symbiont Cells D-alanine Catabolic Process D-serine Metabolic Process Neutrophil-mediated Killing Of Gram-negative Bacterium L-amino Acid Catabolic Process Proteinogenic Amino Acid Catabolic Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Cytokine-mediated Signaling Pathway Hematopoietic Stem Cell Differentiation Hematopoietic Stem Cell Homeostasis ERK1 And ERK2 Cascade
Pathways		Glyoxylate metabolism and glycine degradation Peroxisomal protein import Peroxisomal protein import	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		3,4-Dihydro-2h-Pyrrolium-5-Carboxylate Imino-Tryptophan Flavin adenine dinucleotide D-Tryptophan Flavin-adenine dinucleotide-N5-isobutyl ketone Benzoic acid Anthranilic acid (2E)-3-(3,4-DIHYDROXYPHENYL)-2-IMINOPROPANOIC ACID
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Mean platelet volume ( 32888494) Nicotine dependence and major depression (severity of comorbidity) ( 30287806)	Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Neurociticism ( 29500382)
Interacting Genes		5 interacting genes: AOC1 DAOA EP300 PEX5 PRKAB2	4 interacting genes: ABCB1 CNTNAP4 PIK3R1 UBC
Entrez ID		1610	23014
HPRD ID		15917	09948
Ensembl ID		ENSG00000110887	ENSG00000135108
Uniprot IDs		A0A024RBI1 A0A0S2Z3J4 P14920	O94952 Q4G104 Q8IUQ5
PDB IDs		2DU8 2E48 2E49 2E4A 2E82 3CUK 3G3E 3W4I 3W4J 3W4K 3ZNN 3ZNO 3ZNP 3ZNQ 4QFC 4QFD 5ZJ9 5ZJA 6KBP 7U9S 7U9U 8HY5
Enriched GO Terms of Interacting Partners?		Diamine Oxidase Activity Putrescine Oxidase Activity Histamine Oxidase Activity Peptidyl-lysine Propionylation Carboxylic Acid Metabolic Process Swimming Histone Lactyltransferase (CoA-dependent) Activity Organic Acid Metabolic Process Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Damaged DNA Binding Small Molecule Metabolic Process Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Thigmotaxis Nucleotide Catabolic Process Peptide Lactyltransferase (CoA-dependent) Activity Peroxisome Targeting Sequence Binding Peroxisome Monocarboxylic Acid Metabolic Process Negative Regulation Of Protein Oligomerization Nucleoside Phosphate Catabolic Process Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Uracil DNA N-glycosylase Activity D-amino Acid Metabolic Process	D-serine Catabolic Process Glycine Oxidase Activity D-amino-acid Dehydrogenase Activity D-alanine Catabolic Process Leukocyte Mediated Cytotoxicity Cellular Response To Nonylphenol Response To Quercetin Cellular Response To Borneol Response To Codeine Daunorubicin Transport Positive Regulation Of Establishment Of Sertoli Cell Barrier D-serine Metabolic Process D-amino Acid Catabolic Process D-amino-acid Oxidase Activity Cellular Response To External Biotic Stimulus Response To Antineoplastic Agent Response To Cyclosporin A Cellular Response To Mycotoxin Positive Regulation Of Response To Drug Leukocyte Mediated Immunity Phosphatidylethanolamine Flippase Activity Response To Flavonoid Ceramide Floppase Activity Ceramide Translocation Negative Regulation Of Sensory Perception Of Pain Kinase Regulator Activity Perinuclear Endoplasmic Reticulum Membrane Regulation Of Grooming Behavior D-amino Acid Metabolic Process Neutrophil-mediated Killing Of Gram-negative Bacterium Mitochondrial Outer Membrane L-proline Catabolic Process Cell Killing Response To Thyroxine Protein Localization To Bicellular Tight Junction Regulation Of Chloride Transport External Side Of Apical Plasma Membrane Hyperosmotic Salinity Response Xenobiotic Transport Across Blood-brain Barrier Cellular Hyperosmotic Salinity Response Floppase Activity Sphingolipid Translocation Response To Mycotoxin Phosphatidylcholine Floppase Activity Carboxylic Acid Transmembrane Transporter Activity Terpenoid Transport Response To L-phenylalanine Derivative Establishment Of Blood-retinal Barrier Insulin Binding 1-phosphatidylinositol-3-kinase Regulator Activity
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