ATP2B1 and CCR2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		ATP2B1	CCR2
Description		ATPase plasma membrane Ca2+ transporting 1	C-C motif chemokine receptor 2
Image
GO Annotations	Cellular Component	Immunological Synapse Nucleoplasm Plasma Membrane Membrane Basolateral Plasma Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Intracellular Membrane-bounded Organelle Synapse Extracellular Exosome Photoreceptor Ribbon Synapse Glutamatergic Synapse	Fibrillar Center Cytoplasm Plasma Membrane External Side Of Plasma Membrane Membrane Dendrite Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding P-type Calcium Transporter Activity Protein Binding Calmodulin Binding ATP Binding Calcium Ion Transmembrane Transporter Activity ATP Hydrolysis Activity Metal Ion Binding Molecular Function Inhibitor Activity	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity Cytokine Binding C-C Chemokine Binding CCR2 Chemokine Receptor Binding Chemokine (C-C Motif) Ligand 2 Binding Chemokine (C-C Motif) Ligand 12 Binding Chemokine (C-C Motif) Ligand 7 Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Cytokine Production Regulation Of Vascular Associated Smooth Muscle Contraction Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Regulation Of Blood Pressure Positive Regulation Of Bone Mineralization Monoatomic Ion Transmembrane Transport Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Calcium Ion Transport Calcium Ion Transmembrane Transport Regulation Of Cellular Response To Insulin Stimulus Regulation Of Cardiac Conduction Calcium Ion Export Across Plasma Membrane	Blood Vessel Remodeling Dendritic Cell Chemotaxis Monocyte Chemotaxis Regulation Of T Cell Cytokine Production Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Type 2 Immune Response Intracellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Humoral Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Wounding Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of T Cell Chemotaxis Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Sensory Perception Of Pain Calcium-mediated Signaling Cellular Homeostasis Hemopoiesis Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Tumor Necrosis Factor Production Monocyte Extravasation T-helper 17 Cell Chemotaxis Negative Regulation Of Eosinophil Degranulation Regulation Of T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Homeostasis Of Number Of Cells Within A Tissue Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of T Cell Activation Positive Regulation Of Synaptic Transmission, Glutamatergic Cell Chemotaxis Leukocyte Adhesion To Vascular Endothelial Cell Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Mononuclear Cell Migration Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Inflammatory Response To Wounding Neutrophil Clearance Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Leukocyte Tethering Or Rolling Macrophage Migration Regulation Of Macrophage Migration Regulation Of T Cell Migration Positive Regulation Of Thymocyte Migration Positive Regulation Of Monocyte Extravasation Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Positive Regulation Of Astrocyte Chemotaxis Positive Regulation Of Hematopoietic Stem Cell Migration
Pathways		Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases Sensory processing of sound by inner hair cells of the cochlea	Beta defensins Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs		Ritodrine Halothane Desflurane Sevoflurane	INCB3284 CCX915 Cenicriviroc Plozalizumab
Diseases
GWAS		Adult body size ( 32376654) Automobile speeding propensity ( 30643258) Biomedical quantitative traits ( 19396169) Blood pressure ( 21572416 21909110 24001895 24954895) Calcium levels ( 29403010) Chronotype ( 30696823) Coronary artery disease ( 29212778 32469254 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 22751097) Diastolic blood pressure ( 25249183 28739976 26390057 29403010 30487518 27841878 27618452 19430479) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure (long-term average) ( 28348047) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Diffusing capacity of carbon monoxide ( 30694715) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hypertension ( 30487518 31879980 32709000 31513605 28273873 25249183 19430479) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Magnesium levels ( 20700443) Mean arterial pressure ( 30487518 29403010 26390057 27618448) Mean arterial pressure (long-term average) ( 28348047) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Morning person ( 30696823) Myocardial infarction ( 33532862 26343387) Nonobstructive coronary artery disease ( 26534935) Pulse pressure ( 29403010 26390057 27841878 30578418 30487518 28739976) Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systolic blood pressure ( 28739976 29403010 19430479 25249183 26390057 27618447 27618452 30578418 30487518 30224653 27841878) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure (long-term average) ( 28348047) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Total body bone mineral density ( 29304378)	Blood protein levels ( 23696881) Celiac disease ( 22057235 20190752 24999842 25920553) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 26192919) Monocyte count ( 32888494 27863252 29403010) Monocyte percentage of white cells ( 32888494 27863252) Obesity-related traits ( 23251661) Rheumatoid arthritis ( 32868391) Ulcerative colitis ( 28067908 26192919)
Interacting Genes		7 interacting genes: CALM1 CCR2 CSNK2A1 ERBIN F2RL1 PRKACA PRKCA	40 interacting genes: APP ARL6IP5 ATP2B1 B3GAT3 BLOC1S6 CACYBP CD59 CD81 CDIP1 CLPTM1 DMWD EMC10 ERGIC3 GOT1 GPR161 HERPUD1 HMOX2 JPH3 NDFIP1 NOTCH2 NTNG2 PCMT1 PLLP PTPN9 RGR RHOG RTN3 S1PR5 SCG5 SLC2A1 SLC41A3 SRSF5 SUMO1 SVOP TECPR2 TMEM161A TMEM63A TSPAN7 VMA12 WLS
Entrez ID		490	729230
HPRD ID		00158	19667
Ensembl ID		ENSG00000070961	ENSG00000121807
Uniprot IDs		P20020	P41597
PDB IDs		6A69	2MLO 2MLQ 5T1A 7P8X 7XA3
Enriched GO Terms of Interacting Partners?		Regulation Of Cytokine Production Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Response To Peptide Response To Cytokine Positive Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Intracellular Signal Transduction Regulation Of Chemokine Production Negative Regulation Of Cytokine Production Renal System Process Regulation Of Biological Quality Positive Regulation Of Protein Secretion Regulation Of Multicellular Organismal Process Calcium-mediated Signaling Signal Transduction Calcium Channel Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of System Process Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Cell Cycle Regulation Of Macroautophagy Negative Regulation Of Gene Expression Regulation Of Peptide Hormone Secretion Negative Regulation Of Immune System Process Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Cytokine Production Regulation Of Insulin Secretion Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Vesicle-mediated Transport Regulation Of Exocytosis Negative Regulation Of Chemokine Production Regulation Of Secretion By Cell Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Positive Regulation Of Locomotion Response To Stress Regulation Of Secretion Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Muscle System Process Positive Regulation Of Protein Transport Regulation Of Hormone Secretion Regulation Of Protein Secretion Sperm Midpiece	Membrane Endoplasmic Reticulum Membrane Regulation Of Protein Transport Positive Regulation Of Protein Localization Plasma Membrane Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Catabolic Process Regulation Of Protein Localization Regulation Of Transport Golgi Membrane Nuclear Envelope Lumen Positive Regulation Of Protein Transport Regulation Of Intracellular Protein Transport
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