CNTN2 and NEK2

		CNTN2	NEK2
Description		contactin 2	NIMA related kinase 2
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GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Axon Node Of Ranvier Neuron Projection Neuronal Cell Body Axon Initial Segment Myelin Sheath Juxtaparanode Region Of Axon Synapse Postsynaptic Membrane Side Of Membrane	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Condensed Nuclear Chromosome Spindle Pole Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Plasma Membrane Cilium Microtubule Cytoskeleton Midbody Nuclear Lumen Protein-containing Complex Ciliary Basal Body Intercellular Bridge
	Molecular Function	Protein Binding Carbohydrate Binding Cell Adhesion Mediator Activity Cell-cell Adhesion Mediator Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Microtubule Cytoskeleton Organization Neuron Migration G Protein-coupled Adenosine Receptor Signaling Pathway Response To Dietary Excess Reduction Of Food Intake In Response To Dietary Excess Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Axonal Fasciculation Learning Adult Walking Behavior Positive Regulation Of Protein Processing Protein Processing Cerebral Cortex GABAergic Interneuron Migration Central Nervous System Neuron Differentiation Central Nervous System Myelination Regulation Of Cell Morphogenesis Regulation Of Axon Diameter Neuron Projection Development Receptor Internalization Clustering Of Voltage-gated Potassium Channels Fat Cell Differentiation Negative Regulation Of Neuron Differentiation Regulation Of Neuronal Synaptic Plasticity Regulation Of Astrocyte Differentiation Synapse Organization Establishment Of Localization In Cell Positive Regulation Of Adenosine Receptor Signaling Pathway Dendrite Self-avoidance Protein Localization To Juxtaparanode Region Of Axon Establishment Of Protein Localization To Juxtaparanode Region Of Axon Presynaptic Membrane Organization	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Blastocyst Development Protein Phosphorylation Chromosome Segregation Regulation Of Mitotic Nuclear Division Positive Regulation Of Telomere Maintenance Regulation Of Mitotic Centrosome Separation Protein Autophosphorylation Spindle Assembly Centrosome Separation Cell Division Meiotic Cell Cycle Regulation Of Attachment Of Spindle Microtubules To Kinetochore Mitotic Spindle Assembly Negative Regulation Of Centriole-centriole Cohesion
Pathways		L1CAM interactions NCAM1 interactions NrCAM interactions	APC-Cdc20 mediated degradation of Nek2A Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 GSK3B-mediated proteasomal degradation of PD-L1(CD274)
Drugs			5-[(Z)-(5-Chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N,2,4-trimethyl-1H-pyrrole-3-carboxamide Fostamatinib
Diseases
GWAS		Adventurousness ( 30643258) Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) HDL cholesterol levels ( 32203549) Mean platelet volume ( 24026423) Meat-related diet ( 32066663) Number of sexual partners ( 30643258) Periodontitis (stage III/IV grade C) ( 33745150) Red blood cell count ( 27863252) Schizophrenia ( 30285260) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Red cell distribution width ( 27863252 28957414 32888494) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		12 interacting genes: CDK4 CHEK1 CNTN1 CNTNAP2 EGFR L1CAM NCAN NFYB NRCAM TUBG1 UBE4B VAC14	29 interacting genes: CDC20 CEP250 CHGA CIP2A CSN2 CTNNB1 DCTN1 EDRF1 EIF4A2 FZR1 GIT1 IFT140 IMMT MAD1L1 MAPK1 MCC NDC80 NEK11 PDE4DIP PIN1 PPP1CA PPP1CC PPP1R2 PRKN PTPRD SMURF1 SPTBN4 TCF25 TPM3
Entrez ID		6900	4751
HPRD ID		01826	04953
Ensembl ID		ENSG00000184144	ENSG00000117650
Uniprot IDs		A1L3A3 Q02246	F6U4U2 P51955
PDB IDs		2OM5 8K3J 8K53 9BA4 9BA5	2JAV 2W5A 2W5B 2W5H 2WQO 2XK3 2XK4 2XK6 2XK7 2XK8 2XKC 2XKD 2XKE 2XKF 2XNM 2XNN 2XNO 2XNP 4A4X 4AFE 5M51 5M53 5M55 5M57 6SGD 6SGH 6SGI 6SGK 6SK9 6TM5
Enriched GO Terms of Interacting Partners?		Condensed Nuclear Chromosome Regulation Of Mitotic Centrosome Separation Neuron Projection Development Cell Adhesion Neuronal Ion Channel Clustering Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Regulation Of Cellular Component Organization Axon Central Nervous System Development Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Phase Transition Cell-cell Adhesion Mediator Activity Plasma Membrane Bounded Cell Projection Organization Regulation Of Mitotic Cell Cycle Protein Kinase Activity Cell-cell Adhesion Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Neuron Projection Guidance Axon Guidance Neuron Recognition Brain Development Multivesicular Body, Internal Vesicle Lumen Negative Regulation Of Centriole-centriole Cohesion Nuclear Chromosome Segregation Granzyme-mediated Apoptotic Signaling Pathway PAS Complex Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Cycle Process Kinase Activity Cell Projection Organization Cyclin D1-CDK4 Complex Cyclin D3-CDK4 Complex Ciliary Basal Body Shc-EGFR Complex Microtubule Nucleator Activity Limbic System Development Superior Temporal Gyrus Development Regulation Of Axon Extension Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Cyclin D2-CDK4 Complex Protein Serine Kinase Activity Regulation Of Fibroblast Proliferation Histone H3T11 Kinase Activity Protein Phosphatase Binding Positive Regulation Of Protein Kinase C Signaling	Centrosome Regulation Of Organelle Organization Regulation Of Cell Communication Regulation Of Signal Transduction Regulation Of Signaling Ciliary Basal Body Positive Regulation Of Microtubule Nucleation Regulation Of Cell Cycle Process Regulation Of Cellular Component Organization Ubiquitin Ligase Activator Activity Positive Regulation Of Organelle Organization Intracellular Signal Transduction Organelle Organization Positive Regulation Of Cellular Component Organization Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Checkpoint Regulation Of Microtubule Nucleation Neuron Cellular Homeostasis Regulation Of Centriole-centriole Cohesion Neuronal Cell Body Axon Initial Segment Regulation Of Nuclear Division Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Meiotic Cell Cycle Phase Transition Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Spindle Pole Regulation Of Cell Cycle Acinar Cell Differentiation Synapse Organization Chromosome, Centromeric Region Kinetochore Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Microtubule Polymerization Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Hematopoietic Or Lymphoid Organ Development Cell Division Regulation Of Protein Ubiquitination Regulation Of Developmental Growth Trachea Formation PTW/PP1 Phosphatase Complex Negative Regulation Of Mitotic Nuclear Division Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Cytoskeleton Cytosol Regulation Of Circadian Rhythm
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