NPTX2 and NPTX1

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (affinity chromatography technology)

		NPTX2	NPTX1
Name		neuronal pentraxin 2	neuronal pentraxin 1
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Synapse Presynapse Glutamatergic Synapse	Extracellular Region Endoplasmic Reticulum Transport Vesicle Cytoplasmic Vesicle Synaptic Cleft Glutamatergic Synapse
	Molecular Function	Protein Binding Carbohydrate Binding Metal Ion Binding	Metal Ion Binding
	Biological Process	Chemical Synaptic Transmission Associative Learning	Mitochondrial Transport Chemical Synaptic Transmission Central Nervous System Development Cellular Response To Potassium Ion Mitochondrial Fragmentation Involved In Apoptotic Process Axonogenesis Involved In Innervation Cellular Response To Glucose Stimulus Postsynaptic Density Assembly Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
GWAS		No GWAS studies recorded	Bipolar disorder ( 31043756 ) Blood protein levels ( 30072576 )
Novel Interactors		3 novel interactors: DYNC1I1 NIN NPTX1	7 novel interactors: CASP10 FN1 MXRA7 NPTX2 SLC3A1 STX1B ZNF92
Interacting Genes		1 interacting genes: NPTXR	3 interacting genes: ADRB2 NPTXR RCN2
Entrez ID		4885	4884
HPRD ID		02853	03843
Ensembl ID		ENSG00000106236	ENSG00000171246
Uniprot IDs		P47972	Q15818
PDB IDs		Not available	6YPE
GO Terms Enriched among Interactors		Dynein Heavy Chain Binding Dynein Light Chain Binding Microtubule Spindle Pole Cell Projection Morphogenesis Postsynaptic Density Assembly Cellular Response To Potassium Ion Axonogenesis Involved In Innervation Axonogenesis Neuron Projection Morphogenesis Mitochondrial Fragmentation Involved In Apoptotic Process Postsynaptic Specialization Assembly Microtubule Anchoring At Centrosome Corticospinal Tract Morphogenesis Centriolar Subdistal Appendage Ciliary Transition Fiber Centriole-centriole Cohesion Microtubule Nucleation By Microtubule Organizing Center Microtubule Minus-end Binding Corpus Callosum Morphogenesis Centrosome-templated Microtubule Nucleation Microtubule Anchoring At Microtubule Organizing Center Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Postsynaptic Density Organization Collateral Sprouting Cytoplasmic Dynein Complex Response To Potassium Ion Postsynaptic Specialization Organization Synaptic Cleft Axonal Growth Cone Pericentriolar Material Central Nervous System Projection Neuron Axonogenesis Microtubule Anchoring Spectrin Binding Glutamatergic Synapse Protein Localization To Postsynapse Protein Localization To Postsynaptic Membrane Microtubule Nucleation Central Nervous System Neuron Axonogenesis Centrosome Localization Dynein Complex Mitochondrial Transport Mitotic Spindle Pole Vesicle Transport Along Microtubule Receptor Localization To Synapse Cytoskeletal Motor Activity Microtubule-based Process Vesicle Cytoskeletal Trafficking Microtubule Motor Activity Cytoplasmic Microtubule	Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Mini Excitatory Postsynaptic Potential Positive Regulation Of Spontaneous Neurotransmitter Secretion Negative Regulation Of Macropinocytosis Negative Regulation Of Synaptic Vesicle Recycling