NPTX2 and DYNC1I1

		NPTX2	DYNC1I1
Description		neuronal pentraxin 2	dynein cytoplasmic 1 intermediate chain 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Synapse Presynapse Glutamatergic Synapse	Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleus Chromosome Cytoplasm Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Dynein Complex Vesicle Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Protein Binding Carbohydrate Binding Metal Ion Binding	Cytoskeletal Motor Activity Microtubule Motor Activity Protein Binding Microtubule Binding Spectrin Binding Dynein Light Chain Binding Dynein Heavy Chain Binding
	Biological Process	Chemical Synaptic Transmission Associative Learning	Microtubule-based Movement Transport Along Microtubule Vesicle Transport Along Microtubule
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS			Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 28552196) Immune reponse to smallpox (secreted IL-10) ( 22610502) Knee osteoarthritis ( 27696742) Multisite chronic pain ( 31194737 33830993) Obesity-related traits ( 23251661) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Refractive error ( 32231278)
Interacting Genes		1 interacting genes: NPTXR	35 interacting genes: ACADM ANXA7 BICD1 CADM4 CDKN1A DCTN1 DNM2 DYNLL1 DYNLL2 DYNLRB1 DYNLT1 DYNLT3 EMILIN1 FAM110A FAM83D FBP1 GRB7 GSK3B KAT7 LCOR MCC NAGK NUDT21 PIN1 RAP1GAP RBPMS RCC1 RUNDC3B SMN1 STAU1 TAOK1 TK1 TRIM58 WDCP YTHDF1
Entrez ID		4885	1780
HPRD ID		02853	04798
Ensembl ID		ENSG00000106236	ENSG00000158560
Uniprot IDs		P47972	A4D1I7 O14576 Q8N542
PDB IDs
Enriched GO Terms of Interacting Partners?		Dynein Heavy Chain Binding Dynein Light Chain Binding Microtubule Spindle Pole Cell Projection Morphogenesis Postsynaptic Density Assembly Cellular Response To Potassium Ion Axonogenesis Involved In Innervation Axonogenesis Neuron Projection Morphogenesis Mitochondrial Fragmentation Involved In Apoptotic Process Postsynaptic Specialization Assembly Microtubule Anchoring At Centrosome Corticospinal Tract Morphogenesis Centriolar Subdistal Appendage Ciliary Transition Fiber Centriole-centriole Cohesion Microtubule Nucleation By Microtubule Organizing Center Microtubule Minus-end Binding Corpus Callosum Morphogenesis Centrosome-templated Microtubule Nucleation Microtubule Anchoring At Microtubule Organizing Center Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Postsynaptic Density Organization Collateral Sprouting Cytoplasmic Dynein Complex Response To Potassium Ion Postsynaptic Specialization Organization Synaptic Cleft Axonal Growth Cone Pericentriolar Material Central Nervous System Projection Neuron Axonogenesis Microtubule Anchoring Spectrin Binding Glutamatergic Synapse Protein Localization To Postsynapse Protein Localization To Postsynaptic Membrane Microtubule Nucleation Central Nervous System Neuron Axonogenesis Centrosome Localization Dynein Complex Mitochondrial Transport Mitotic Spindle Pole Vesicle Transport Along Microtubule Receptor Localization To Synapse Cytoskeletal Motor Activity Microtubule-based Process Vesicle Cytoskeletal Trafficking Microtubule Motor Activity Cytoplasmic Microtubule	Dynein Intermediate Chain Binding Dynein Complex Cytoplasmic Dynein Complex Microtubule-based Process Microtubule Microtubule Associated Complex Tau Protein Binding Cytoplasmic Stress Granule Microtubule-based Movement Centrosome Regulation Of Microtubule-based Process Regulation Of Microtubule Cytoskeleton Organization Regulation Of Intracellular Transport Stress Granule Assembly Identical Protein Binding Microtubule Cytoskeleton Organization Positive Regulation Of Protein Localization To Centrosome Cellular Component Assembly Regulation Of Long-term Synaptic Potentiation Cytoplasm Secretory Vesicle Regulation Of DNA Replication Ciliary Tip Regulation Of Cell Cycle Microtubule Cytoskeleton Organization Involved In Mitosis Response To Phorbol 13-acetate 12-myristate Intracellular MRNA Localization Regulation Of Protein Localization To Centrosome Positive Regulation Of Intracellular Transport Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway MRNA Binding Microtubule Anchoring At Microtubule Organizing Center Microtubule Cytoskeleton Viral Process Mitotic Cell Cycle Phase Transition Dynactin Binding Replicative Senescence Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway MRNA Export From Nucleus Membraneless Organelle Assembly Regulation Of DNA-templated DNA Replication Initiation Regulation Of Cellular Component Organization Negative Regulation Of Phosphate Metabolic Process Cell Cycle Phase Transition Scaffold Protein Binding Negative Regulation Of Cellular Response To Vascular Endothelial Growth Factor Stimulus Cytoskeleton Protein Kinase Binding Transport Along Microtubule Organelle Localization
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