NPR2 and NPPB

Number of citations of the paper that reports this interaction (PubMedID 1672777)
0

Data Source:
BioGRID (pull down)

		NPR2	NPPB
Description		natriuretic peptide receptor 2	natriuretic peptide B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Cilium Membrane Neuron Projection Synapse	Extracellular Region Extracellular Space Cytoplasm Protein-containing Complex
	Molecular Function	Nucleotide Binding Guanylate Cyclase Activity Protein Kinase Activity Protein Binding ATP Binding GTP Binding Lyase Activity Phosphorus-oxygen Lyase Activity Natriuretic Peptide Receptor Activity Peptide Hormone Binding Hormone Binding Identical Protein Binding	Signaling Receptor Binding Hormone Activity Protein Binding Diuretic Hormone Activity Guanylate Cyclase Activator Activity Hormone Receptor Binding
	Biological Process	MAPK Cascade Ossification Ovarian Follicle Development Cumulus Cell Differentiation Blood Vessel Development Vasculogenesis Lymph Vessel Development Endochondral Ossification Startle Response Blood Vessel Remodeling Chondrocyte Differentiation Growth Plate Cartilage Development CGMP Biosynthetic Process Vacuole Organization Receptor Guanylyl Cyclase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Chemical Synaptic Transmission Germ Cell Development Spermatogenesis Single Fertilization Axonogenesis Sensory Perception Of Sound Blood Circulation Regulation Of Blood Pressure Cyclic Nucleotide Biosynthetic Process Response To Wounding Response To Hormone Neuronal Action Potential Vestibulocochlear Nerve Development Vestibulocochlear Nerve Maturation Nerve Development Female Genitalia Development Response To Luteinizing Hormone Limb Morphogenesis Genitalia Morphogenesis Multicellular Organism Growth Gastric Emptying Intracellular Signal Transduction Chondrocyte Proliferation Post-anal Tail Morphogenesis CGMP Metabolic Process Digestive Tract Morphogenesis Digestive Tract Development Oocyte Development Collateral Sprouting Smooth Muscle Tissue Development White Fat Cell Differentiation Cartilage Development Chromosome Organization Meiotic Cell Cycle Neuron Apoptotic Process Negative Regulation Of Meiotic Cell Cycle Limb Development Bone Development Axonogenesis Involved In Innervation Activation Of Meiosis Involved In Egg Activation Vascular Wound Healing C-di-GMP Signaling Cellular Response To CGMP Response To Fibroblast Growth Factor Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Execution Phase Of Apoptosis Bone Growth Negative Regulation Of Oocyte Maturation Cellular Response To Peptide Response To Salt Meiotic Cell Cycle Process Involved In Oocyte Maturation	System Process Negative Regulation Of Systemic Arterial Blood Pressure Cardiac Conduction System Development CGMP Biosynthetic Process Protein Folding Cell Surface Receptor Signaling Pathway Receptor Guanylyl Cyclase Signaling Pathway Neuropeptide Signaling Pathway Body Fluid Secretion Regulation Of Blood Pressure Negative Regulation Of Angiogenesis CGMP-mediated Signaling Negative Regulation Of Cell Growth Killing Of Cells Of Another Organism Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Vasodilation Regulation Of Vascular Permeability Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Blood Vessel Diameter Maintenance
Pathways		Physiological factors
Drugs		Erythrityl tetranitrate Nesiritide Vosoritide	Carvedilol Oxymetholone
Diseases		Acromesomelic dysplasia, Maroteaux type
GWAS		Brain morphology (MOSTest) ( 32665545) Heel bone mineral density ( 30598549) Height ( 31562340)	B-type natriuretic peptide levels ( 25561047 29237677) B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio ( 29237677) Blood pressure ( 21909110) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Diastolic blood pressure ( 27618452 28739976) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hip index ( 34021172) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) N-terminal pro B-type natriuretic peptide levels ( 29237677) NT-proBNP levels in acute coronary syndrome ( 26908625) Pulse pressure ( 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure ( 28739976 27618452 27618447 19430483) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Tuberculosis ( 29036319)
Interacting Genes		3 interacting genes: NPPA NPPB NPPC	13 interacting genes: CYSRT1 EWSR1 GEMIN4 HDAC4 KRT40 KRTAP10-3 KRTAP10-9 NOTCH2NLA NPR1 NPR2 NPR3 PSMA3 SERTAD3
Entrez ID		4882	4879
HPRD ID		00166	08974
Ensembl ID		ENSG00000159899	ENSG00000120937
Uniprot IDs		P20594	P16860
PDB IDs			1YK1 3N56
Enriched GO Terms of Interacting Partners?		Hormone Receptor Binding Guanylate Cyclase Activator Activity Receptor Guanylyl Cyclase Signaling Pathway CGMP Biosynthetic Process CGMP Metabolic Process Cyclic Nucleotide Biosynthetic Process CGMP-mediated Signaling Cyclic Purine Nucleotide Metabolic Process Positive Regulation Of CGMP-mediated Signaling Hormone Activity Purine Ribonucleotide Biosynthetic Process Enzyme-linked Receptor Protein Signaling Pathway Blood Vessel Diameter Maintenance Ribose Phosphate Biosynthetic Process Regulation Of Tube Size Regulation Of CGMP-mediated Signaling Purine Nucleotide Biosynthetic Process Cardiac Conduction System Development Nucleotide Biosynthetic Process Protein Folding Purine-containing Compound Biosynthetic Process Negative Regulation Of Systemic Arterial Blood Pressure Vascular Process In Circulatory System Nucleoside Phosphate Biosynthetic Process Purine Ribonucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Circulatory System Process Purine Nucleotide Metabolic Process Regulation Of Vascular Permeability Negative Regulation Of Blood Pressure Signaling Receptor Binding Nucleotide Metabolic Process Vasodilation Carbohydrate Derivative Biosynthetic Process Cardiac Muscle Tissue Development Purine-containing Compound Metabolic Process Organophosphate Biosynthetic Process Nucleoside Phosphate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Regulation Of Growth Cell Surface Receptor Signaling Pathway Neuropeptide Signaling Pathway Negative Regulation Of Collecting Lymphatic Vessel Constriction Extracellular Region Diuretic Hormone Activity Protein-containing Complex Striated Muscle Tissue Development Carbohydrate Derivative Metabolic Process Neuropeptide Receptor Binding	Natriuretic Peptide Receptor Activity CGMP Biosynthetic Process Hormone Binding CGMP Metabolic Process Cyclic Nucleotide Biosynthetic Process Peptide Hormone Binding Cyclic Purine Nucleotide Metabolic Process Guanylate Cyclase Activity Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Urine Volume Receptor Guanylyl Cyclase Signaling Pathway Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Keratin Filament Phosphorus-oxygen Lyase Activity Regulation Of Urine Volume Purine Ribonucleotide Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase I Neuronal Action Potential Ribose Phosphate Biosynthetic Process Intermediate Filament Regulation Of Cell Growth Negative Regulation Of Cell Growth Regulation Of Blood Pressure Purine Nucleotide Biosynthetic Process G Protein-coupled Peptide Receptor Activity Regulation Of Myotube Differentiation Regulation Of Transcription By RNA Polymerase I Positive Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Blood Circulation Nucleotide Biosynthetic Process ANPR-A Receptor Complex Vestibulocochlear Nerve Maturation Blood Vessel Remodeling D-glucose:proton Symporter Activity Galactose:proton Symporter Activity Regulation Of Glycolytic Process Negative Regulation Of Growth Purine-containing Compound Biosynthetic Process Cajal Body Regulation Of Locomotor Rhythm Regulation Of Carbohydrate Catabolic Process TFIIIC-class Transcription Factor Complex Binding Cumulus Cell Differentiation C-di-GMP Signaling Activation Of Meiosis Involved In Egg Activation Gastric Emptying Sucrose Transport Sucrose:proton Symporter Activity Nucleobase-containing Small Molecule Metabolic Process Regulation Of ATP Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?