NPR3

Name	natriuretic peptide receptor 3
Structure
Novel Interactors	3 novel interactors: NFKBIE NSD1 SLC30A9
Interactors	3 interactors: NPPA NPPB NPPC
GO Annotations	Cellular Component	Plasma Membrane Membrane Protein-containing Complex Extracellular Exosome
	Molecular Function	Protein Binding G Protein-coupled Peptide Receptor Activity Natriuretic Peptide Receptor Activity Peptide Hormone Binding Chloride Ion Binding Peptide Binding Hormone Binding Protein Homodimerization Activity Receptor Decoy Activity
	Biological Process	Skeletal System Development Angiogenesis Blood Vessel Remodeling Osteoclast Proliferation Response To Ischemia CGMP Biosynthetic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of Blood Pressure Regulation Of Osteoblast Proliferation Positive Regulation Of Urine Volume Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Relaxation Of Smooth Muscle
Drugs	Nesiritide
GWAS	Appendicular lean mass ( 33097823 ) Blood pressure ( 21572416 21909110 24954895 ) Diastolic blood pressure ( 27618452 27841878 26390057 28739976 21909115 ) Diastolic blood pressure (cigarette smoking interaction) ( 29455858 ) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962 ) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Height ( 31562340 28552196 28270201 19570815 23563607 19343178 20881960 25282103 ) Hip circumference adjusted for BMI ( 34021172 25673412 ) Hypertension ( 31879980 21909115 ) Mean arterial pressure ( 26390057 30487518 29403010 ) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962 ) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962 ) Ovarian reserve ( 22116950 ) Pulse pressure ( 30578418 28739976 27841878 ) Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962 ) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962 ) Symptoms in placebo-treated COVID-19 outpatients at risk of severe disease (time to remission) ( 34035401 ) Systolic blood pressure ( 30578418 21909115 27618447 29403010 28739976 28135244 27841878 26390057 27618452 ) Systolic blood pressure (cigarette smoking interaction) ( 29455858 ) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962 ) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500 ) Waist circumference adjusted for BMI in active individuals ( 28448500 ) Waist circumference adjusted for body mass index ( 28448500 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Entrez ID	4883
HPRD ID	00167
Ensembl ID	ENSG00000113389
Uniprot IDs	A8K4A5 C9JK69 P17342 Q60I31
PDB IDs	1JDN 1JDP 1YK0 1YK1
GO Terms Enriched among Interactors ?	Hormone Receptor Binding Guanylate Cyclase Activator Activity Receptor Guanylyl Cyclase Signaling Pathway CGMP Biosynthetic Process CGMP Metabolic Process Cyclic Nucleotide Biosynthetic Process CGMP-mediated Signaling Cyclic Purine Nucleotide Metabolic Process Positive Regulation Of CGMP-mediated Signaling Hormone Activity Regulation Of CGMP-mediated Signaling Purine Ribonucleotide Biosynthetic Process Blood Vessel Diameter Maintenance Cardiac Conduction System Development Regulation Of Tube Size Ribose Phosphate Biosynthetic Process Purine Nucleotide Biosynthetic Process Negative Regulation Of Systemic Arterial Blood Pressure Protein Folding Nucleotide Biosynthetic Process Purine-containing Compound Biosynthetic Process Vascular Process In Circulatory System Nucleoside Phosphate Biosynthetic Process Purine Ribonucleotide Metabolic Process Regulation Of Vascular Permeability Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Negative Regulation Of Blood Pressure Nuclear Receptor Binding Circulatory System Process Vasodilation Purine Nucleotide Metabolic Process Cardiac Muscle Tissue Development Signaling Receptor Binding Nucleotide Metabolic Process Negative Regulation Of Collecting Lymphatic Vessel Constriction Diuretic Hormone Activity Carbohydrate Derivative Biosynthetic Process Purine-containing Compound Metabolic Process Neuropeptide Signaling Pathway Organophosphate Biosynthetic Process Nucleoside Phosphate Metabolic Process Neuropeptide Receptor Binding Response To 3-methylcholanthrene Cumulus Cell Differentiation C-di-GMP Signaling Multicellular Organismal Locomotion Gastric Emptying Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Nucleobase-containing Small Molecule Metabolic Process