NPAT and CCNA1

Number of citations: 35 (PubMedID 10995387)
Data Source: BioGRID (pull down)

		NPAT	CCNA1
Name		nuclear protein, coactivator of histone transcription	cyclin A1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cajal Body Gemini Of Cajal Bodies	Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol Microtubule Cytoskeleton Cyclin A1-CDK1 Complex Cyclin A1-CDK2 Complex Cyclin A2-CDK2 Complex
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
	Biological Process	In Utero Embryonic Development Cell Cycle G1/S Phase Transition Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	G1/S Transition Of Mitotic Cell Cycle Male Meiosis I Spermatogenesis Cell Division
Pathways		None	G0 and Early G1 Telomere Extension By Telomerase Cdc20:Phospho-APC/C mediated degradation of Cyclin A Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence Ub-specific processing proteases Processing of DNA double-strand break ends TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation G2 Phase Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G1/S-Specific Transcription Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
GWAS		Lymphocyte percentage of white cells ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Monocyte count ( 32888494 ) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 ) Nonunion in individuals with fractures ( 30680360 ) Platelet count ( 32888494 ) Plateletcrit ( 27863252 ) Refractive error ( 32231278 )	Cocaine dependence ( 31212010 ) Nickel levels ( 26025379 )
Novel Interactors		1 novel interactors: DDX10	None recorded
Interacting Genes		3 interacting genes: CCNA1 CREBBP POU2F1	40 interacting genes: ANAPC4 ARID2 BRCA1 BRCA2 CABLES1 CDC20 CDC25A CDK1 CDK2 CDKN1A CDKN1B CKS1B CKS2 CUX1 E2F1 FZR1 GPS2 H1-1 H1-5 H2BC1 INCA1 KLHDC9 MCM4 MCM6 MYBL2 NPAT PGR PROCA1 PSMA2 RACK1 RB1 RBL1 RBL2 RBM4 RPA1 SP1 SRC TRIM13 WEE1 XRCC6
Entrez ID		4863	8900
HPRD ID		03266	04946
Ensembl ID		ENSG00000149308	ENSG00000133101
Uniprot IDs		Q14207	A0A140VJG0 P78396
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Histone H3K27 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Cyclin A2-CDK2 Complex Cyclin A1-CDK1 Complex Cyclin A1-CDK2 Complex MRF Binding Anterior Head Development	Cyclin Binding Regulation Of Mitotic Cell Cycle Nucleoplasm Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Primary Metabolic Process Negative Regulation Of Cell Cycle Process Regulation Of DNA Metabolic Process Mitotic Cell Cycle Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Replication Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA Replication Nucleus Cell Cycle G1/S Phase Transition Signal Transduction In Response To DNA Damage Regulation Of Catalytic Activity Cell Division Regulation Of G2/M Transition Of Mitotic Cell Cycle Chromosome Organization Regulation Of Kinase Activity Regulation Of Metabolic Process Chromosome, Telomeric Region Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process G1/S Transition Of Mitotic Cell Cycle Regulation Of Phosphorylation Regulation Of Lipid Kinase Activity Cyclin-dependent Protein Kinase Holoenzyme Complex DNA Damage Checkpoint Signaling G2/M Transition Of Mitotic Cell Cycle DNA Damage Response Regulation Of Protein Modification Process Cellular Response To Stress Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Cell Cycle G2/M Phase Transition Positive Regulation Of DNA Metabolic Process