GPS2 and CNOT2

Number of citations of the paper that reports this interaction (PubMedID 16712523)
45

Data Source:
BioGRID (two hybrid)

		GPS2	CNOT2
Description		G protein pathway suppressor 2	CCR4-NOT transcription complex subunit 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol Transcription Repressor Complex	P-body Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane CCR4-NOT Complex CCR4-NOT Core Complex
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity GTPase Inhibitor Activity Protein Binding Cyclin Binding	Transcription Corepressor Binding Transcription Coregulator Activity Poly(A)-specific Ribonuclease Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II JNK Cascade Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Regulation Of Lipid Metabolic Process B Cell Differentiation Negative Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Negative Regulation Of Inflammatory Response Negative Regulation Of B Cell Receptor Signaling Pathway Response To Mitochondrial Depolarisation Negative Regulation Of Protein K63-linked Ubiquitination	Negative Regulation Of Transcription By RNA Polymerase II Nuclear-transcribed MRNA Poly(A) Tail Shortening Trophectodermal Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Translation Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Regulatory NcRNA-mediated Gene Silencing Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Stem Cell Population Maintenance
Pathways		PPARA activates gene expression HDACs deacetylate histones Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors
Drugs
Diseases
GWAS		Liver enzyme levels (alkaline phosphatase) ( 33972514)	Amyotrophic lateral sclerosis (age of onset) ( 22959728) Diastolic blood pressure ( 27841878) Ovarian cancer ( 30557369) Triglyceride levels ( 32154731)
Interacting Genes		53 interacting genes: ACTMAP AKAP8L ATF4 ATF5 BAG4 BRME1 CCNA1 CHD3 CNOT2 CYSRT1 DAZAP2 EP300 FAM168B FHL5 GOLGA2 HDAC1 HDAC3 HNRNPH1 HOXA1 INTS11 KRT27 KRT31 KRT34 KRT36 KRTAP11-1 KRTAP13-2 KRTAP3-1 KRTAP3-3 KRTAP6-1 KRTAP6-2 KRTAP6-3 MAP3K7CL NCOR1 NDOR1 NR0B2 OIP5 PBK POU2AF1 PRMT6 PRR22 RBPMS SESTD1 SETDB1 SMUG1 SPDL1 TBL1X TBL1XR1 TFIP11 TP53 TP53BP2 TRIP6 UBTD2 VPS37C	27 interacting genes: ARMC5 BCL6 BEX1 CCHCR1 CFAP68 CIMIP1 CNOT1 CNOT3 CNOT8 CSTF2 DDB1 DSCR9 GALNT10 GCSAM GPS1 GPS2 HSF2BP MTFR1L NCOR1 NCOR2 OBI1 PRR35 PSMB4 RACK1 TBX2 TEKT3 ZFHX3
Entrez ID		2874	4848
HPRD ID		11878	05367
Ensembl ID		ENSG00000132522	ENSG00000111596
Uniprot IDs		Q13227	B2RDX7 B3KTL6 F8VUB4 F8VV52 Q9NZN8
PDB IDs		2L5G	4C0D 4C0F 5FU6 5FU7
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Circadian Rhythm Transcription Repressor Complex Structural Molecule Activity Histone Deacetylase Complex Rhythmic Process Transcription Cis-regulatory Region Binding P53 Binding NF-kappaB Binding Transcription Corepressor Binding Protein Binding Protein Lysine Delactylase Activity Cytosol Structural Constituent Of Skin Epidermis Circadian Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Nucleus Positive Regulation Of DNA-templated Transcription Transcription Corepressor Activity Histone Deacetylase Binding Protein Decrotonylase Activity Histone Decrotonylase Activity Tissue Development Promoter-specific Chromatin Binding Mitotic Spindle Intermediate Filament Organization Nuclear Thyroid Hormone Receptor Binding Negative Regulation Of RNA Metabolic Process Chromatin Positive Regulation Of RNA Metabolic Process Chromatin Binding Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Androgen Receptor Signaling Pathway Cellular Response To UV Organelle Organization Negative Regulation Of Metabolic Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Negative Regulation Of Macromolecule Metabolic Process Epigenetic Regulation Of Gene Expression DNA-binding Transcription Factor Binding Chromatin Organization Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding	CCR4-NOT Core Complex CCR4-NOT Complex Nuclear-transcribed MRNA Poly(A) Tail Shortening Rhythmic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction GTPase Inhibitor Activity Transcription Repressor Complex Poly(A)-specific Ribonuclease Activity RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Nuclear Retinoic Acid Receptor Binding Trophectodermal Cell Differentiation Negative Regulation Of Androgen Receptor Signaling Pathway Nucleus P-body Transcription Regulator Complex Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cellular Senescence Regulation Of B Cell Receptor Signaling Pathway Nuclear-transcribed MRNA Catabolic Process Axonemal A Tubule Inner Sheath Negative Regulation Of MiRNA Transcription Nucleoplasm Negative Regulation Of Macromolecule Metabolic Process MRNA Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle DNA Replication Negative Regulation Of JNK Cascade Cyclin Binding Negative Regulation Of Cardiac Chamber Formation Histone Deacetylase Binding Negative Regulation Of Heart Looping Regulation Of Androgen Receptor Signaling Pathway Regulation Of Brood Size Outer Acrosomal Membrane Adrenal Cortex Development Negative Regulation Of Biosynthetic Process Regulation Of Protein Metabolic Process
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