NHLH2 and KCNIP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NHLH2	KCNIP1
Description		nescient helix-loop-helix 2	potassium voltage-gated channel interacting protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Cytoplasm Plasma Membrane Voltage-gated Potassium Channel Complex Cytoplasmic Side Of Plasma Membrane Membrane Dendrite Monoatomic Ion Channel Complex Cell Projection Synapse Kv4.3-KChIP1 Channel Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity Transmembrane Transporter Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Central Nervous System Development Peripheral Nervous System Development Male Gonad Development Cell Migration In Hindbrain Hypothalamus Gonadotrophin-releasing Hormone Neuron Development Cell Differentiation Ovulation Cycle Positive Regulation Of Transcription By RNA Polymerase II Male Mating Behavior	Monoatomic Ion Transport Potassium Ion Transport Muscle Contraction Chemical Synaptic Transmission Regulation Of Heart Contraction Regulation Of Signal Transduction Monoatomic Ion Transmembrane Transport Potassium Ion Transmembrane Transport Membrane Repolarization Potassium Ion Export Across Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport
Pathways			Phase 1 - inactivation of fast Na+ channels
Drugs
Diseases
GWAS		Electrocardiographic traits (multivariate) ( 32602732) Heart rate variability traits (SDNN) ( 28610988) Metabolite levels ( 23823483)	Acne (severe) ( 24927181) California verbal learning test score ( 31596458) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Normalized brain volume ( 19010793) Placental abruption ( 29884306) Pre-treatment viral load in HIV-1 infection ( 31219150) Short-term memory (digit-span task) ( 30741946)
Interacting Genes		8 interacting genes: CFTR HES1 KCNIP1 LMO3 MYF5 TAF1D TCF12 TCF4	16 interacting genes: AMPD3 ASPH CIAO2A DAAM2 IL6ST KCND1 KCND2 KCND3 KCNIP2 LITAF NHLH2 NIF3L1 SOD3 SPP1 SPRED2 TBC1D25
Entrez ID		4808	30820
HPRD ID		01213	06879
Ensembl ID		ENSG00000177551	ENSG00000182132
Uniprot IDs		Q02577	Q9NZI2
PDB IDs			1S1E 2I2R 2NZ0 7E83 7E84 7F3F 7W6N 7W6T
Enriched GO Terms of Interacting Partners?		E-box Binding Protein Dimerization Activity Positive Regulation Of Developmental Process Positive Regulation Of Cell Differentiation Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Monoatomic Ion Transport Regulation Of Developmental Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Cell Differentiation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Negative Regulation Of Pancreatic A Cell Differentiation Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Oculomotor Nerve Development N-box Binding Negative Regulation Of Cell Fate Determination Regulation Of RNA Biosynthetic Process Chromatin Positive Regulation Of RNA Metabolic Process Cajal-Retzius Cell Differentiation Positive Regulation Of Mitotic Cell Cycle, Embryonic Negative Regulation Of Forebrain Neuron Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Hindbrain Morphogenesis Trochlear Nerve Development Renal Interstitial Fibroblast Development Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Neuron Differentiation Kv4.3-KChIP1 Channel Complex Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Protein-folding Chaperone Binding Positive Regulation Of Enamel Mineralization Positive Regulation Of Monoatomic Anion Transport Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Regulation Of Timing Of Neuron Differentiation Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Ureteric Bud Morphogenesis Regulation Of RNA Metabolic Process DNA Binding Negative Regulation Of Lymphoid Progenitor Cell Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation Negative Regulation Of Amacrine Cell Differentiation Nervous System Development Negative Regulation Of Pro-B Cell Differentiation	A-type (transient Outward) Potassium Channel Activity Potassium Channel Activity Voltage-gated Potassium Channel Complex Kv4.2-KChIP2 Channel Complex Membrane Repolarization Action Potential Monoatomic Ion Channel Complex Regulation Of System Process Potassium Ion Transmembrane Transport Voltage-gated Potassium Channel Activity Potassium Ion Transport Regulation Of Heart Contraction Muscle Contraction Regulation Of Blood Circulation Muscle System Process Detection Of Calcium Ion Metal Ion Transport Membrane Repolarization During Cardiac Muscle Cell Action Potential Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Membrane Repolarization During Action Potential Neuronal Cell Body Inorganic Ion Transmembrane Transport Dendritic Spine Postsynaptic Specialization Membrane Regulation Of Multicellular Organismal Process Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Monoatomic Ion Channel Activity Regulation Of Membrane Potential Protein Homooligomerization Dendrite Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Monoatomic Ion Transport Postsynaptic Membrane Peptidyl-aspartic Acid 3-dioxygenase Activity Interleukin-27 Receptor Activity Leukemia Inhibitory Factor Receptor Activity Regulation Of Glial Cell Differentiation Interleukin-6 Binding Interleukin-6 Receptor Activity Oncostatin-M Receptor Complex Protein Complex Oligomerization Kv4.3-KChIP1 Channel Complex Hypothalamus Gonadotrophin-releasing Hormone Neuron Development Positive Regulation Of Estradiol Secretion Cytoplasmic Side Of Late Endosome Membrane Metal Ion Binding AMP Deaminase Activity Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity
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