NHLH2

Description		nescient helix-loop-helix 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Central Nervous System Development Peripheral Nervous System Development Male Gonad Development Cell Migration In Hindbrain Hypothalamus Gonadotrophin-releasing Hormone Neuron Development Cell Differentiation Ovulation Cycle Positive Regulation Of Transcription By RNA Polymerase II Male Mating Behavior
Pathways
Drugs
Diseases
GWAS		Electrocardiographic traits (multivariate) ( 32602732) Heart rate variability traits (SDNN) ( 28610988) Metabolite levels ( 23823483)
Interacting Genes		8 interacting genes: CFTR HES1 KCNIP1 LMO3 MYF5 TAF1D TCF12 TCF4
Entrez ID		4808
HPRD ID		01213
Ensembl ID		ENSG00000177551
Uniprot IDs		Q02577
PDB IDs
Enriched GO Terms of Interacting Partners?		E-box Binding Protein Dimerization Activity Positive Regulation Of Developmental Process Positive Regulation Of Cell Differentiation Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Monoatomic Ion Transport Regulation Of Developmental Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Cell Differentiation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Negative Regulation Of Pancreatic A Cell Differentiation Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Oculomotor Nerve Development N-box Binding Negative Regulation Of Cell Fate Determination Regulation Of RNA Biosynthetic Process Chromatin Positive Regulation Of RNA Metabolic Process Cajal-Retzius Cell Differentiation Positive Regulation Of Mitotic Cell Cycle, Embryonic Negative Regulation Of Forebrain Neuron Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Hindbrain Morphogenesis Trochlear Nerve Development Renal Interstitial Fibroblast Development Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Neuron Differentiation Kv4.3-KChIP1 Channel Complex Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Protein-folding Chaperone Binding Positive Regulation Of Enamel Mineralization Positive Regulation Of Monoatomic Anion Transport Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Regulation Of Timing Of Neuron Differentiation Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Ureteric Bud Morphogenesis Regulation Of RNA Metabolic Process DNA Binding Negative Regulation Of Lymphoid Progenitor Cell Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation Negative Regulation Of Amacrine Cell Differentiation Nervous System Development Negative Regulation Of Pro-B Cell Differentiation
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