NDUFS3 and GZMA

Number of citations of the paper that reports this interaction (PubMedID 18485875)
51

Data Source:
BioGRID (enzymatic study)

		NDUFS3	GZMA
Description		NADH:ubiquinone oxidoreductase core subunit S3	granzyme A
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane Nuclear Body Mitochondrial Membrane Respiratory Chain Complex I	Immunological Synapse Extracellular Region Extracellular Space Nucleus Cytoplasm
	Molecular Function	NADH Dehydrogenase Activity Protein Binding NADH Dehydrogenase (ubiquinone) Activity Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On NAD(P)H	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Protein Homodimerization Activity
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Aerobic Respiration Substantia Nigra Development Mitochondrial Respiratory Chain Complex I Assembly Proton Motive Force-driven Mitochondrial ATP Synthesis Reactive Oxygen Species Metabolic Process Proton Transmembrane Transport	Proteolysis Apoptotic Process Immune Response Response To Bacterium Killing Of Cells Of Another Organism Negative Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation Of Oxidoreductase Activity Proteolysis Involved In Protein Catabolic Process Protein Maturation Pyroptotic Inflammatory Response Granzyme-mediated Programmed Cell Death Signaling Pathway Cytotoxic T Cell Pyroptotic Cell Death
Pathways		Respiratory electron transport Complex I biogenesis RHOG GTPase cycle Mitochondrial protein degradation
Drugs		NADH
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Adult body size ( 32376654) Alcohol use disorder (total score) ( 30336701) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Bipolar disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 20935630) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Fruit consumption ( 32066663) Height ( 28552196) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Mood instability ( 31168069) Neuroticism ( 29255261) Refractive error ( 32231278) Sleep duration (short sleep) ( 30846698)
Interacting Genes		3 interacting genes: GZMA RASL10B TMEM11	17 interacting genes: ACTG1 APEX1 GOLGA2 H1-1 H2BC21 HDC HMGB2 HNRNPK HSP90AA1 HSPA4 LMNA LMNB1 NCL NDUFS3 SET XRCC5 XRCC6
Entrez ID		4722	3001
HPRD ID		10355	00771
Ensembl ID		ENSG00000213619	ENSG00000145649
Uniprot IDs		O75489	P12544
PDB IDs		5XTB 5XTD 5XTH 5XTI	1OP8 1ORF
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Deoxyribonuclease Activity Negative Regulation Of Endodeoxyribonuclease Activity Cytotoxic T Cell Pyroptotic Cell Death Regulation Of Systemic Arterial Blood Pressure By Atrial Natriuretic Peptide Negative Regulation Of Nuclease Activity Negative Regulation Of Oxidoreductase Activity Regulation Of Endodeoxyribonuclease Activity Granzyme-mediated Programmed Cell Death Signaling Pathway Negative Regulation Of DNA Binding Pyroptotic Cell Death Regulation Of Oxidoreductase Activity Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal	Chromatin Remodeling Double-stranded Telomeric DNA Binding Double-stranded DNA Binding Damaged DNA Binding Chromosome Organization Chromatin Organization Structural Constituent Of Nuclear Lamina Telomere Maintenance Telomeric DNA Binding DNA End Binding Ku70:Ku80 Complex Protein-containing Complex Assembly Negative Regulation Of Metabolic Process Nucleosome Assembly Protein-containing Complex Organization DNA Metabolic Process Telomere Organization DNA-dependent Protein Kinase Complex Nucleosome Organization Lamin Filament Nuclear Pore Localization Negative Regulation Of Macromolecule Metabolic Process DNA Binding DNA-dependent Protein Kinase-DNA Ligase 4 Complex 5'-deoxyribose-5-phosphate Lyase Activity Nonhomologous End Joining Complex Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Double-strand Break Repair Via Nonhomologous End Joining Nuclear Telomere Cap Complex Negative Regulation Of Biosynthetic Process Protein-DNA Complex Assembly Chromosome Cellular Component Assembly Nuclear Lamina Protein Localization To Nuclear Envelope Organelle Organization Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA Recombination Protein-containing Complex Nucleus Organization Structural Constituent Of Cytoskeleton Positive Regulation Of Biosynthetic Process Response To Salt Stress Nucleoplasm Epigenetic Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Telomere Maintenance
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