NDUFS3

Description		NADH:ubiquinone oxidoreductase core subunit S3
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane Nuclear Body Mitochondrial Membrane Respiratory Chain Complex I
	Molecular Function	NADH Dehydrogenase Activity Protein Binding NADH Dehydrogenase (ubiquinone) Activity Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On NAD(P)H
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Aerobic Respiration Substantia Nigra Development Mitochondrial Respiratory Chain Complex I Assembly Proton Motive Force-driven Mitochondrial ATP Synthesis Reactive Oxygen Species Metabolic Process Proton Transmembrane Transport
Pathways		Respiratory electron transport Complex I biogenesis RHOG GTPase cycle Mitochondrial protein degradation
Drugs		NADH
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Adult body size ( 32376654) Alcohol use disorder (total score) ( 30336701) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Bipolar disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 20935630) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Fruit consumption ( 32066663) Height ( 28552196) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Mood instability ( 31168069) Neuroticism ( 29255261) Refractive error ( 32231278) Sleep duration (short sleep) ( 30846698)
Interacting Genes		3 interacting genes: GZMA RASL10B TMEM11
Entrez ID		4722
HPRD ID		10355
Ensembl ID		ENSG00000213619
Uniprot IDs		O75489
PDB IDs		5XTB 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Deoxyribonuclease Activity Negative Regulation Of Endodeoxyribonuclease Activity Cytotoxic T Cell Pyroptotic Cell Death Regulation Of Systemic Arterial Blood Pressure By Atrial Natriuretic Peptide Negative Regulation Of Nuclease Activity Negative Regulation Of Oxidoreductase Activity Regulation Of Endodeoxyribonuclease Activity Granzyme-mediated Programmed Cell Death Signaling Pathway Negative Regulation Of DNA Binding Pyroptotic Cell Death Regulation Of Oxidoreductase Activity Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal
Tagcloud ?