NDUFS1 and MDH2

Number of citations of the paper that reports this interaction (PMID 6439716)
18

Data Source:
HPRD (in vitro)

		NDUFS1	MDH2
Gene Name		NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)	malate dehydrogenase 2, NAD (mitochondrial)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I Mitochondrial Intermembrane Space	Nucleus Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding NADH Dehydrogenase (ubiquinone) Activity Electron Carrier Activity Metal Ion Binding 2 Iron, 2 Sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	L-malate Dehydrogenase Activity Protein Self-association Poly(A) RNA Binding Malate Dehydrogenase (NADP+) Activity
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Apoptotic Mitochondrial Changes Respiratory Electron Transport Chain Cellular Metabolic Process Small Molecule Metabolic Process Cellular Respiration ATP Metabolic Process Regulation Of Mitochondrial Membrane Potential Reactive Oxygen Species Metabolic Process	Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Tricarboxylic Acid Cycle Oxaloacetate Metabolic Process Malate Metabolic Process Internal Protein Amino Acid Acetylation NADH Metabolic Process Pathogenesis Cellular Metabolic Process Cellular Carbohydrate Metabolic Process Small Molecule Metabolic Process
Pathways		Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport	Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport Metabolism of carbohydrates Citric acid cycle (TCA cycle)
Drugs		NADH	NADH Citric Acid
Diseases
GWAS
Protein-Protein Interactions		3 interactors: CASP3 KDM1A MDH2	7 interactors: CRYAB CS FH GOT2 NDUFS1 PC WARS
Entrez ID		4719	4191
HPRD ID		01145	01099
Ensembl ID			ENSG00000146701
Uniprot IDs		E5KRK5 P28331	B3KTM1 B4DE44 E9PDB2 G3XAL0 P40926
PDB IDs			2DFD
Enriched GO Terms of Interacting Partners?		Regulation Of Primitive Erythrocyte Differentiation Myeloid Cell Differentiation Glial Cell Apoptotic Process Regulation Of Apoptotic DNA Fragmentation Negative Regulation Of Histone H3-K4 Methylation Histone H3-K9 Demethylation Histone H3-K4 Demethylation Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of Hormone Biosynthetic Process Negative Regulation Of Histone H3-K9 Methylation Negative Regulation Of Activated T Cell Proliferation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator NADH Metabolic Process Oxaloacetate Metabolic Process Malate Metabolic Process Granulocyte Differentiation Hemopoiesis Negative Regulation Of B Cell Proliferation Regulation Of Megakaryocyte Differentiation Apoptotic DNA Fragmentation Negative Regulation Of Histone Methylation Response To Wounding Positive Regulation Of Erythrocyte Differentiation Immune System Development Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Platelet Formation Platelet Morphogenesis Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Histone H3-K4 Methylation Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Hormone Biosynthetic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Hippo Signaling Apoptotic Nuclear Changes Release Of Cytochrome C From Mitochondria Regulation Of Hematopoietic Progenitor Cell Differentiation Negative Regulation Of Protein Metabolic Process Regulation Of Hormone Metabolic Process Histone Lysine Demethylation Negative Regulation Of Apoptotic Process Histone Demethylation Negative Regulation Of Programmed Cell Death Regulation Of Erythrocyte Differentiation	Fumarate Metabolic Process Dicarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Small Molecule Metabolic Process Oxaloacetate Metabolic Process Cellular Respiration Tricarboxylic Acid Cycle Energy Derivation By Oxidation Of Organic Compounds Citrate Metabolic Process Tricarboxylic Acid Metabolic Process Gluconeogenesis Aerobic Respiration Hexose Biosynthetic Process Generation Of Precursor Metabolites And Energy Glutamate Catabolic Process To 2-oxoglutarate Glutamate Catabolic Process To Aspartate Aspartate Biosynthetic Process Tryptophanyl-tRNA Aminoacylation Glucose Metabolic Process Carbohydrate Biosynthetic Process Aspartate Catabolic Process 4-hydroxyproline Catabolic Process L-kynurenine Metabolic Process Pathogenesis Hexose Metabolic Process Glutamate Catabolic Process Aspartate Metabolic Process Tubulin Complex Assembly Monosaccharide Metabolic Process Carbohydrate Metabolic Process Cellular Metabolic Process Biotin Metabolic Process Kynurenine Metabolic Process Dicarboxylic Acid Catabolic Process 2-oxoglutarate Metabolic Process Apoptotic Process Involved In Morphogenesis Cellular Response To Gamma Radiation 4-hydroxyproline Metabolic Process Cellular Modified Amino Acid Catabolic Process Apoptotic Process Involved In Development Cellular Amino Acid Metabolic Process Glutamate Metabolic Process Oxidation-reduction Process Regulation Of Mitochondrial Membrane Potential Developmental Programmed Cell Death Microtubule Polymerization Or Depolymerization Monocarboxylic Acid Metabolic Process Homeostasis Of Number Of Cells Within A Tissue Negative Regulation Of Reactive Oxygen Species Metabolic Process
Tagcloud ?		acantholysis anxa8l1 atp2c1 blistering c5a cd1b cd32 cd88 cdh8 cdh9 chrm3 chrnd chrne col21a1 cyb5b desmoglein dra dsc1 dsc3 gp1ba justifies mucocutaneous multiplexed pdha1 pemphigus pkp3 pmp22 slc36a4 sod2	aggravating anxa1 banks bedside confidently cons fth1 ftl gliosis got2 immunochemical infarct infarcted infarcts itraq lagging leak malate mortem plex pros proteome proteomics putamen shuttle slc25a11 slc25a12 tca vim
Tagcloud (Difference) ?		acantholysis anxa8l1 atp2c1 blistering c5a cd1b cd32 cd88 cdh8 cdh9 chrm3 chrnd chrne col21a1 cyb5b desmoglein dra dsc1 dsc3 gp1ba justifies mucocutaneous multiplexed pdha1 pemphigus pkp3 pmp22 slc36a4 sod2	aggravating anxa1 banks bedside confidently cons fth1 ftl gliosis got2 immunochemical infarct infarcted infarcts itraq lagging leak malate mortem plex pros proteome proteomics putamen shuttle slc25a11 slc25a12 tca vim
Tagcloud (Intersection) ?