NDUFS1 and MDH2

Number of citations: 0 (PubMedID 6439716)
Data Source: HPRD (in vitro)

		NDUFS1	MDH2
Name		NADH:ubiquinone oxidoreductase core subunit S1	malate dehydrogenase 2
Structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Membrane Respiratory Chain Complex I	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Membrane Extracellular Exosome
	Molecular Function	Protein Binding NADH Dehydrogenase (ubiquinone) Activity Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On NAD(P)H Metal Ion Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	RNA Binding Catalytic Activity Oxidoreductase Activity Malate Dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor L-malate Dehydrogenase (NAD+) Activity Identical Protein Binding L-malate Dehydrogenase (NADP+) Activity
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Aerobic Respiration Mitochondrial Respiratory Chain Complex I Assembly ATP Synthesis Coupled Electron Transport Proton Motive Force-driven Mitochondrial ATP Synthesis Cellular Respiration Proton Transmembrane Transport	Gluconeogenesis Tricarboxylic Acid Cycle Malate Metabolic Process Aerobic Respiration NAD+ Metabolic Process Carboxylic Acid Metabolic Process Malate-aspartate Shuttle
Pathways		Respiratory electron transport Complex I biogenesis Mitochondrial protein degradation	Citric acid cycle (TCA cycle) Mitochondrial protein degradation Malate-aspartate shuttle
Drugs		NADH	NADH Citric acid Xanthinol
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome	None
GWAS		Body mass index ( 26426971 ) Chronotype ( 30696823 ) Daytime nap ( 33568662 ) Frontotemporal dementia with GRN mutation ( 29724592 ) Morning person ( 30696823 )	Coffee consumption ( 31959922 )
Novel Interactors		2 novel interactors: CFC1 CFLAR	None recorded
Interacting Genes		5 interacting genes: C1QTNF9 CASP3 KDM1A MDH2 MDM2	11 interacting genes: CRYAB CS FH GOT2 HSPB1 LINC00632 NDUFS1 PC PSMA1 SHANK3 WARS1
Entrez ID		4719	4191
HPRD ID		01145	01099
Ensembl ID		ENSG00000023228	ENSG00000146701
Uniprot IDs		E5KRK5 P28331	A0A024R4K3 B3KTM1 G3XAL0 P40926
PDB IDs		5XTB 5XTD 5XTH 5XTI	2DFD 4WLE 4WLF 4WLN 4WLO 4WLU 4WLV
GO Terms Enriched among Interactors		Death-inducing Signaling Complex Death Receptor Binding Response To Ionizing Radiation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Response To UV Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Response To Gamma Radiation Cellular Response To Alkaloid Response To Steroid Hormone Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Apoptotic Signaling Pathway Response To Antibiotic Heart Development Negative Regulation Of Signal Transduction By P53 Class Mediator Response To Hypoxia Response To Decreased Oxygen Levels Response To Light Stimulus Response To Gamma Radiation Response To Oxygen Levels Cysteine-type Endopeptidase Activity Positive Regulation Of Neuron Apoptotic Process L-malate Dehydrogenase (NADP+) Activity P53 Binding Cellular Response To Ionizing Radiation Response To Formaldehyde Cellular Response To Vitamin B1 Regulation Of Apoptotic Signaling Pathway Enzyme Activator Activity Response To Alkaloid Response To Radiation Cellular Response To UV Regulation Of Neuron Projection Development Protease Binding Response To Hydrogen Peroxide Phospholipase A2 Activator Activity Cellular Response To Light Stimulus Response To Toxic Substance Skeletal Myofibril Assembly Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Response To Estradiol Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Cysteine-type Peptidase Activity Response To Glucocorticoid L-malate Dehydrogenase (NAD+) Activity Malate Dehydrogenase Activity Response To Vitamin B1 Response To Water-immersion Restraint Stress	Mitochondrial Matrix Contractile Muscle Fiber Extracellular Exosome Protein Refolding Tricarboxylic Acid Cycle Mitochondrion NAD+ Metabolic Process Citrate Synthase Activity Fumarate Metabolic Process Fumarate Hydratase Activity Amino Acid Metabolic Process Negative Regulation Of Protein Kinase C Signaling Pyruvate Carboxylase Activity Small Molecule Metabolic Process Acyltransferase Activity, Acyl Groups Converted Into Alkyl On Transfer Catalytic Activity L-glutamate Catabolic Process To Aspartate L-aspartate:2-oxoglutarate Aminotransferase Activity Aspartate Biosynthetic Process Purine Nucleotide Metabolic Process Proteasome Complex Viral RNA Genome Packaging Tryptophan-tRNA Ligase Activity Tryptophanyl-tRNA Aminoacylation Guanylate Kinase-associated Protein Clustering Response To Heat Dicarboxylic Acid Metabolic Process L-aspartate Catabolic Process Nucleotide Metabolic Process Protein Kinase C Inhibitor Activity Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Unfolded Protein Binding Z Disc Citrate Metabolic Process Regulation Of Arginine Metabolic Process Nicotinamide Nucleotide Metabolic Process Trans-4-hydroxy-L-proline Catabolic Process Kynurenine-oxoglutarate Transaminase Activity Purine-containing Compound Metabolic Process Regulation Of Protein Kinase C Signaling Ligase Activity Biotin Binding Negative Regulation Of Cell Volume AMPA Glutamate Receptor Clustering Synaptic Receptor Adaptor Activity NMDA Glutamate Receptor Clustering