NDUFS1

Description		NADH:ubiquinone oxidoreductase core subunit S1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Membrane Respiratory Chain Complex I
	Molecular Function	Protein Binding NADH Dehydrogenase (ubiquinone) Activity Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On NAD(P)H Metal Ion Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Aerobic Respiration Mitochondrial Respiratory Chain Complex I Assembly ATP Synthesis Coupled Electron Transport Proton Motive Force-driven Mitochondrial ATP Synthesis Cellular Respiration Proton Transmembrane Transport
Pathways		Respiratory electron transport Complex I biogenesis Mitochondrial protein degradation
Drugs		NADH
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Body mass index ( 26426971) Chronotype ( 30696823) Daytime nap ( 33568662) Frontotemporal dementia with GRN mutation ( 29724592) Morning person ( 30696823)
Novel Interacting Genes		2 novel interacting genes: CFC1 CFLAR
Interacting Genes		5 interacting genes: C1QTNF9 CASP3 KDM1A MDH2 MDM2
Entrez ID		4719
HPRD ID		01145
Ensembl ID		ENSG00000023228
Uniprot IDs		E5KRK5 P28331
PDB IDs		5XTB 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?		Death-inducing Signaling Complex Death Receptor Binding Response To Ionizing Radiation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Response To UV Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Response To Gamma Radiation Cellular Response To Alkaloid Response To Steroid Hormone Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Apoptotic Signaling Pathway Response To Antibiotic Heart Development Negative Regulation Of Signal Transduction By P53 Class Mediator Response To Hypoxia Response To Decreased Oxygen Levels Response To Light Stimulus Response To Gamma Radiation Response To Oxygen Levels Cysteine-type Endopeptidase Activity Positive Regulation Of Neuron Apoptotic Process L-malate Dehydrogenase (NADP+) Activity P53 Binding Cellular Response To Ionizing Radiation Response To Formaldehyde Cellular Response To Vitamin B1 Regulation Of Apoptotic Signaling Pathway Enzyme Activator Activity Response To Alkaloid Response To Radiation Cellular Response To UV Regulation Of Neuron Projection Development Protease Binding Response To Hydrogen Peroxide Phospholipase A2 Activator Activity Cellular Response To Light Stimulus Response To Toxic Substance Skeletal Myofibril Assembly Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Response To Estradiol Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Cysteine-type Peptidase Activity Response To Glucocorticoid L-malate Dehydrogenase (NAD+) Activity Malate Dehydrogenase Activity Response To Vitamin B1 Response To Water-immersion Restraint Stress
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