CYBA and NOX1

Number of citations of the paper that reports this interaction (PMID 15322091)
111

Data Source:
HPRD (in vitro, in vivo)

		CYBA	NOX1
Gene Name		cytochrome b-245, alpha polypeptide	NADPH oxidase 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Endosome Golgi Apparatus Plasma Membrane Membrane Apical Plasma Membrane Secretory Granule Dendrite Phagocytic Vesicle Membrane NADPH Oxidase Complex Neuronal Cell Body Perinuclear Endoplasmic Reticulum	Early Endosome Integral Component Of Membrane Cell Junction NADPH Oxidase Complex Invadopodium Membrane
	Molecular Function	Protein Binding Electron Carrier Activity Superoxide-generating NADPH Oxidase Activity SH3 Domain Binding Heme Binding Metal Ion Binding Protein Heterodimerization Activity	Protein Binding Superoxide-generating NADPH Oxidase Activity Voltage-gated Proton Channel Activity Metal Ion Binding Rac GTPase Binding NADP Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Negative Regulation Of Glomerular Filtration By Angiotensin Superoxide Metabolic Process Inflammatory Response Smooth Muscle Hypertrophy Cytochrome Complex Assembly Positive Regulation Of Cell Growth Response To Nutrient Levels Response To Drug Superoxide Anion Generation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Innate Immune Response Respiratory Burst Vascular Endothelial Growth Factor Receptor Signaling Pathway Hydrogen Peroxide Biosynthetic Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Interaction With Host Oxidation-reduction Process Positive Regulation Of Mucus Secretion Response To Interleukin-1 Cellular Response To Amino Acid Stimulus Cellular Response To Mechanical Stimulus Cellular Response To Glucose Stimulus Cellular Response To Tumor Necrosis Factor Cellular Response To Organic Cyclic Compound Cellular Response To Gamma Radiation Phagosome Maturation	Angiogenesis Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin NADP Metabolic Process Superoxide Metabolic Process Inflammatory Response Signal Transduction Regulation Of Blood Pressure Positive Regulation Of Cell Proliferation Positive Regulation Vascular Endothelial Growth Factor Production Proton Transport Cell Migration Extracellular Matrix Organization Regulation Of Ion Transmembrane Transport Superoxide Anion Generation Hydrogen Peroxide Metabolic Process Positive Regulation Of Integrin Biosynthetic Process Respiratory Burst Positive Regulation Of JNK Cascade Positive Regulation Of Smooth Muscle Cell Proliferation Intracellular PH Elevation Oxidation-reduction Process Cellular Response To Hyperoxia Oxygen Metabolic Process Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Cellular Stress Response To Acidic PH
Pathways		Signaling by VEGF Phagosomal maturation (early endosomal stage) Latent infection of Homo sapiens with Mycobacterium tuberculosis Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation VEGFA-VEGFR2 Pathway Cross-presentation of particulate exogenous antigens (phagosomes) Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: CPT1A CYBB MDFI NCF1 NCF2 NCF4 NOX1 PSMA3 RAC1 RBPMS RCHY1 UPF2	1 interactors: CYBA
Entrez ID		1535	27035
HPRD ID		01989	02203
Ensembl ID		ENSG00000051523	ENSG00000007952
Uniprot IDs		B4DT46 P13498	A6NGA6 Q1ZYL4 Q9Y5S8
PDB IDs		1WLP
Enriched GO Terms of Interacting Partners?		Respiratory Burst Superoxide Anion Generation Vascular Endothelial Growth Factor Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Superoxide Metabolic Process Phagosome Maturation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Peptide Antigen Interaction With Host Antigen Processing And Presentation Reactive Oxygen Species Metabolic Process Hydrogen Peroxide Metabolic Process Hydrogen Peroxide Biosynthetic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Inflammatory Response Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Hyperoxia Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Immune Response Defense Response Immune System Process Cellular Defense Response Innate Immune Response Response To Stress Oxidation-reduction Process Cellular Stress Response To Acidic PH Positive Regulation Of Phosphorylation Cellular Response To Stimulus Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Signal Transduction Metabolic Process Oxygen Metabolic Process Positive Regulation Of Integrin Biosynthetic Process Engulfment Of Apoptotic Cell Positive Regulation Of JNK Cascade Regulation Of Cellular Protein Metabolic Process Response To Drug Signaling Mast Cell Chemotaxis Regulation Of Integrin Biosynthetic Process Positive Regulation Of Stress-activated MAPK Cascade	Negative Regulation Of Glomerular Filtration By Angiotensin Smooth Muscle Hypertrophy Regulation Of Renal Output By Angiotensin Smooth Muscle Adaptation Negative Regulation Of Glomerular Filtration Hydrogen Peroxide Biosynthetic Process Regulation Of Blood Volume By Renin-angiotensin Positive Regulation Of Systemic Arterial Blood Pressure Respiratory Burst Regulation Of Glomerular Filtration Positive Regulation Of Mucus Secretion Superoxide Anion Generation Regulation Of Mucus Secretion Cellular Response To Gamma Radiation Cytochrome Complex Assembly Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Muscle Hypertrophy Hydrogen Peroxide Metabolic Process Positive Regulation Of Blood Pressure Superoxide Metabolic Process Phagosome Maturation Response To Gamma Radiation Cellular Response To Ionizing Radiation Cellular Response To Glucose Stimulus Cellular Response To Amino Acid Stimulus Positive Regulation Of Endothelial Cell Proliferation Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To Mechanical Stimulus Cellular Glucose Homeostasis Cellular Response To Carbohydrate Stimulus Regulation Of Calcium Ion Transport Into Cytosol Response To Interleukin-1 Regulation Of Endothelial Cell Proliferation Regulation Of Systemic Arterial Blood Pressure Renal System Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Tumor Necrosis Factor Interaction With Host Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Reactive Oxygen Species Metabolic Process Response To Amino Acid Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Positive Regulation Of Cell Growth Response To Tumor Necrosis Factor Response To Glucose Cellular Response To Radiation Response To Ionizing Radiation Positive Regulation Of Epithelial Cell Proliferation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of Ion Homeostasis
Tagcloud ?		anion besides biopsies chl copy cybb deleterious deletions downregulation exert hodgkin hybridisation lines lymphoma nadph ncf1 ncf2 ncf4 oxidase phagocytic profiling progenitors proved quantify recurrent reed sternberg subsets superoxide	adenine anion anions artemisia bioactive capillaris cat catalase cathepsin csrc dinucleotide dismutase hepatoprotective immunosuppressive nadph nfatc1 nicotinamide osteoclast osteoporotic protecting rankl scavenging scoparone sod1 superoxide suppressive tartrate thunb traf6
Tagcloud (Difference) ?		besides biopsies chl copy cybb deleterious deletions downregulation exert hodgkin hybridisation lines lymphoma ncf1 ncf2 ncf4 oxidase phagocytic profiling progenitors proved quantify recurrent reed sternberg subsets	adenine anions artemisia bioactive capillaris cat catalase cathepsin csrc dinucleotide dismutase hepatoprotective immunosuppressive nfatc1 nicotinamide osteoclast osteoporotic protecting rankl scavenging scoparone sod1 suppressive tartrate thunb traf6
Tagcloud (Intersection) ?		anion nadph superoxide