CYBA and NOX1

Number of citations of the paper that reports this interaction (PubMedID 15322091)
0

Data Source:
HPRD (in vitro, in vivo)

		CYBA	NOX1
Description		cytochrome b-245 alpha chain	NADPH oxidase 1
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Endosome Endoplasmic Reticulum Membrane Plasma Membrane Focal Adhesion Membrane Apical Plasma Membrane Secretory Granule Dendrite Phagocytic Vesicle Membrane Specific Granule Membrane NADPH Oxidase Complex Neuronal Cell Body Tertiary Granule Membrane Perinuclear Endoplasmic Reticulum	Cytoplasm Endosome Early Endosome Plasma Membrane Membrane Cell Projection NADPH Oxidase Complex Anchoring Junction
	Molecular Function	Protein Binding Electron Transfer Activity Superoxide-generating NAD(P)H Oxidase Activity Oxidoreductase Activity SH3 Domain Binding Heme Binding Metal Ion Binding Protein Heterodimerization Activity	Protein Binding NAD(P)H Oxidase H2O2-forming Activity Superoxide-generating NAD(P)H Oxidase Activity Oxidoreductase Activity Small GTPase Binding Metal Ion Binding NADP Binding Oxidoreductase Activity, Acting On NAD(P)H, Oxygen As Acceptor Superoxide-generating NADPH Oxidase Activity
	Biological Process	Response To Hypoxia Positive Regulation Of Endothelial Cell Proliferation Negative Regulation Of Glomerular Filtration By Angiotensin Superoxide Metabolic Process Inflammatory Response Response To Xenobiotic Stimulus Response To Activity Smooth Muscle Hypertrophy Cytochrome Complex Assembly Positive Regulation Of Cell Growth Response To Nutrient Levels Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Superoxide Anion Generation Innate Immune Response Respiratory Burst Positive Regulation Of Blood Pressure Positive Regulation Of Smooth Muscle Cell Proliferation Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Phagocytosis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Establishment Of Localization In Cell Mucus Secretion Positive Regulation Of Mucus Secretion Response To Interleukin-1 Cellular Response To Mechanical Stimulus Cellular Response To Glucose Stimulus Cellular Response To Tumor Necrosis Factor Cellular Response To Gamma Radiation Reactive Oxygen Species Metabolic Process Positive Regulation Of Defense Response To Bacterium Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Response To Aldosterone Cellular Response To Angiotensin Cellular Response To Phorbol 13-acetate 12-myristate Cellular Response To L-glutamine	MAPK Cascade Angiogenesis Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin NADP+ Metabolic Process Defense Response Inflammatory Response Signal Transduction JNK Cascade Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Vascular Endothelial Growth Factor Production Cell Migration Extracellular Matrix Organization Superoxide Anion Generation Hydrogen Peroxide Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Integrin Biosynthetic Process Respiratory Burst Positive Regulation Of JNK Cascade Positive Regulation Of Smooth Muscle Cell Proliferation Cellular Response To Hyperoxia Oxygen Metabolic Process Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways		ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases Neutrophil degranulation RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle WNT5:FZD7-mediated leishmania damping	RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC3 GTPase cycle WNT5:FZD7-mediated leishmania damping
Drugs		Dextromethorphan	Oxygen
Diseases		Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS		Glycated hemoglobin levels ( 24647736) Hair color ( 26926045)
Interacting Genes		12 interacting genes: APPBP2 CPT1A CYBB MDFI NCF2 NCF4 NOX1 PSMA3 RAC1 RBPMS RCHY1 UPF2	6 interacting genes: ARHGEF7 CYBA FBXW7 NOXA1 NOXO1 TBXA2R
Entrez ID		1535	27035
HPRD ID		01989	02203
Ensembl ID		ENSG00000051523	ENSG00000007952
Uniprot IDs		B4DT46 H3BNP7 P13498	A6NGA6 Q1ZYL4 Q9Y5S8
PDB IDs		1WLP 7U8G 7YXW 8GZ3 8KEI 8WEJ 8X2L
Enriched GO Terms of Interacting Partners?		NADPH Oxidase Complex Respiratory Burst Superoxide Anion Generation Superoxide Metabolic Process Reactive Oxygen Species Metabolic Process Superoxide-generating NAD(P)H Oxidase Activity Oxidoreductase Activity, Acting On NAD(P)H, Oxygen As Acceptor Phagolysosome Superoxide-generating NADPH Oxidase Activity Superoxide-generating NADPH Oxidase Activator Activity NAD(P)H Oxidase H2O2-forming Activity Hydrogen Peroxide Metabolic Process Cytoplasm Animal Organ Regeneration Electron Transfer Activity	NADPH Oxidase Complex Superoxide Anion Generation Superoxide Metabolic Process Reactive Oxygen Species Metabolic Process Superoxide-generating NADPH Oxidase Activator Activity Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Respiratory Burst Positive Regulation Of Blood Pressure Smooth Muscle Hypertrophy Negative Regulation Of Glomerular Filtration By Angiotensin Thromboxane Receptor Activity Thromboxane A2 Signaling Pathway Thromboxane A2 Receptor Activity Negative Regulation Of Microtubule Nucleation SH3 Domain Binding Regulation Of Renal Output By Angiotensin Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Negative Regulation Of Hepatocyte Proliferation Phosphothreonine Residue Binding Cellular Response To L-glutamine Regulation Of Blood Pressure Cellular Response To Radiation Negative Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mucus Secretion Ubiquitin Recycling Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Osteoclast Development Regulation Of Blood Volume By Renin-angiotensin Smooth Muscle Adaptation Response To Ketone Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Guanyl-nucleotide Exchange Factor Activity Positive Regulation Of Lamellipodium Morphogenesis Regulation Of Mucus Secretion Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Muscle System Process Ubiquitin-protein Transferase Activator Activity Regulation Of Osteoclast Development Hydrogen Peroxide Biosynthetic Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Superoxide-generating NAD(P)H Oxidase Activity Regulation Of Body Fluid Levels Cellular Response To Phorbol 13-acetate 12-myristate Response To Alcohol Regulation Of Lamellipodium Morphogenesis Regulation Of SREBP Signaling Pathway Response To Xenobiotic Stimulus Positive Regulation Of Defense Response To Bacterium
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