TRPC6

Description		transient receptor potential cation channel subfamily C member 6
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Cation Channel Complex Slit Diaphragm
	Molecular Function	Actin Binding Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Clathrin Binding Protein Homodimerization Activity Actinin Binding ATPase Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Monoatomic Ion Transport Monoatomic Cation Transport Calcium Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Single Fertilization Neuron Differentiation Positive Regulation Of Ion Transmembrane Transporter Activity Monoatomic Ion Transmembrane Transport Positive Regulation Of Neuron Differentiation Negative Regulation Of Dendrite Morphogenesis Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Calcium Ion Transport Transmembrane Transport Cellular Response To Hydrogen Peroxide Calcium Ion Transmembrane Transport Cellular Response To Hypoxia
Pathways		Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels TRP channels Role of second messengers in netrin-1 signaling
Drugs
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Change in LVEF in response to paclitaxel and trastuzumab in HER2+ breast cancer ( 28763429) Daytime nap ( 33568662) DHEAS levels ( 34748635) Femur bone mineral density x serum urate levels interaction ( 34046847) General risk tolerance (MTAG) ( 30643258) Lung adenocarcinoma ( 28604730) Menarche (age at onset) ( 25231870) Monocyte count ( 32888494) Plateletcrit ( 32888494) Severity of nausea and vomiting of pregnancy ( 29563502) White blood cell count ( 32888494)
Interacting Genes		9 interacting genes: FYN ITPR3 MX1 ORAI1 RNF24 SRC TRPC3 TRPC7 TRPM2
Entrez ID		7225
HPRD ID		04710
Ensembl ID		ENSG00000137672
Uniprot IDs		Q9Y210
PDB IDs		5YX9 6UZ8 6UZA 7A6U 7DXF 7DXG
Enriched GO Terms of Interacting Partners?		Calcium Ion Transport Calcium Channel Activity Store-operated Calcium Channel Activity Calcium Ion Transmembrane Transport Inositol 1,4,5 Trisphosphate Binding Metal Ion Transport Monoatomic Cation Transport Monoatomic Ion Channel Activity Monoatomic Ion Transport Cellular Response To Hydrogen Peroxide Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Intracellularly Gated Calcium Channel Activity Inorganic Ion Transmembrane Transport Phospholipase Activator Activity Response To Hydrogen Peroxide Manganese Ion Transport Monoatomic Ion Transmembrane Transport Cellular Response To Reactive Oxygen Species Cation Channel Complex Response To Calcium Ion Cellular Response To Platelet-derived Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Stimulatory C-type Lectin Receptor Signaling Pathway Phospholipase Binding Cellular Response To Lectin Response To Reactive Oxygen Species Fc Receptor Mediated Stimulatory Signaling Pathway Response To Platelet-derived Growth Factor Calcium-mediated Signaling Ephrin Receptor Binding Negative Regulation Of Inflammatory Response To Antigenic Stimulus Transmembrane Transport Membrane Raft Plasma Membrane Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Oxidative Stress Fc-gamma Receptor Signaling Pathway Calcium Ion Homeostasis Calcium Ion Import Regulation Of Calcium Ion Transport Leukocyte Migration Non-membrane Spanning Protein Tyrosine Kinase Activity Homeostatic Process Membrane T Cell Costimulation Ephrin Receptor Signaling Pathway Cellular Response To Chemical Stress Perinuclear Region Of Cytoplasm Peptidyl-tyrosine Phosphorylation
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