WFDC12 and SLC39A7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		WFDC12	SLC39A7
Description		WAP four-disulfide core domain 12	solute carrier family 39 member 7
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity	Zinc Ion Transmembrane Transporter Activity Protein Binding Metal Ion Transmembrane Transporter Activity
	Biological Process	Antibacterial Humoral Response Defense Response To Bacterium Innate Immune Response	Monoatomic Ion Transport Zinc Ion Transport Intracellular Zinc Ion Homeostasis Metal Ion Transport B Cell Differentiation Transmembrane Transport Zinc Ion Transmembrane Transport Skin Epidermis Development Regulation Of Ferroptosis
Pathways			Zinc influx into cells by the SLC39 gene family
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756 34002096)
Interacting Genes		6 interacting genes: ASPH SGTA SGTB SLC39A7 UBQLN1 UBQLN2	29 interacting genes: AQP6 BIK CLCA4 CRCT1 ERCC6 GJA8 KCNF1 KRTAP1-3 KRTAP5-7 KRTAP9-2 LCE1A LCE1C LCE1F LCE2C LCE2D LCE4A LCE5A LELP1 RGS17 RSPO2 SHISAL1 SLC34A2 SMCP SPRY3 TMEM14B TNFRSF10D UNC93A WFDC12 YY1
Entrez ID		128488	7922
HPRD ID		15674	09028
Ensembl ID		ENSG00000168703	ENSG00000112473
Uniprot IDs		Q8WWY7	A0A024RCX7 B4DZZ8 Q92504
PDB IDs			8GZE
Enriched GO Terms of Interacting Partners?		TRC Complex Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Proteolysis Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Transport Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Muscle Contraction Regulation Of Transport Regulation Of Proteasomal Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Protein Catabolic Process Smooth Muscle Contraction Mature B Cell Apoptotic Process Negative Regulation Of Adenosine Receptor Signaling Pathway Muscle System Process 2'-deoxyadenosine Deaminase Activity Xanthine Biosynthetic Process Negative Regulation Of Penile Erection Regulation Of Monoatomic Cation Transmembrane Transport Response To Endoplasmic Reticulum Stress Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Germinal Center Formation Negative Regulation Of Mucus Secretion Mononuclear Cell Differentiation Inosine Biosynthetic Process Penile Erection Hypoxanthine Salvage DATP Catabolic Process Peptidyl-aspartic Acid 3-dioxygenase Activity Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Protein Targeting To Membrane Negative Regulation Of G Protein-coupled Receptor Internalization Esophagus Smooth Muscle Contraction Autophagosome Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Negative Regulation Of Mature B Cell Apoptotic Process B Cell Differentiation DATP Metabolic Process	Keratinization Epidermis Development Tissue Development
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