MAP3K11 and FKBP2

		MAP3K11	FKBP2
Description		mitogen-activated protein kinase kinase kinase 11	FKBP prolyl isomerase 2
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GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Small GTPase Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine Kinase Activity	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding FK506 Binding Isomerase Activity
	Biological Process	MAPK Cascade Protein Phosphorylation Microtubule-based Process JNK Cascade Positive Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Apoptotic Process Cell Cycle G1/S Phase Transition Positive Regulation Of JNK Cascade Protein Autophosphorylation
Pathways		RAF activation Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF CDC42 GTPase cycle RHOG GTPase cycle RHOV GTPase cycle Signaling downstream of RAS mutants
Drugs		Fostamatinib
Diseases
GWAS		Acne (severe) ( 24927181 30542056) Coronary artery disease ( 29212778) Eosinophil count ( 27863252) Estimated glomerular filtration rate ( 31015462) Gout ( 25646370) Mean platelet volume ( 27863252) Refractive error ( 32231278) Serum uric acid levels ( 32514006) Sum eosinophil basophil counts ( 27863252) Type 2 diabetes ( 28566273 30297969) Waist circumference adjusted for body mass index ( 34021172)	Bipolar disorder ( 34002096) Crohn's disease ( 28067908) Fruit consumption ( 32066663)
Interacting Genes		29 interacting genes: AKT1 APP CDC42 CHUK CLEC4G COPS5 DSCAM EPS8 IKBKB KIF17 KIF3A KIF3B KIFAP3 LATS1 MAP2K4 MAP2K7 MAP3K12 MAP3K21 MAP4K1 MAP4K2 MAPK8IP1 MAPK8IP2 MAPK8IP3 PIN1 RAC1 RHOG SH3RF1 STUB1 TRAF6	14 interacting genes: ARFGEF1 BAG6 BARD1 C1QC EPB41 EPB41L2 MAPK3 RAB3C RAB6A RAP2A UBQLN1 UBQLN2 UBQLN4 VAMP2
Entrez ID		4296	2286
HPRD ID		02502	01742
Ensembl ID		ENSG00000173327	ENSG00000173486
Uniprot IDs		Q16584	A0A494C1N0 P26885 Q53XJ5
PDB IDs		5K26 5K28 6AQB 6CQ7	2PBC 4NNR
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette MAPK Cascade Intracellular Signal Transduction Regulation Of JNK Cascade Regulation Of MAPK Cascade JNK Cascade Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Postsynapse Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Positive Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Nucleotide Binding Kinesin II Complex MAP-kinase Scaffold Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Axo-dendritic Transport Protein Kinase Binding Protein Serine Kinase Activity Regulation Of Apoptotic Process Protein Kinase Activity Transport Along Microtubule Regulation Of Programmed Cell Death Signal Transduction Glutamatergic Synapse Cytoskeleton-dependent Intracellular Transport Fc-epsilon Receptor Signaling Pathway Plus-end-directed Vesicle Transport Along Microtubule Regulation Of Signal Transduction ATP Binding Microtubule-based Transport Kinase Activity Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Plus-end-directed Organelle Transport Along Microtubule Regulation Of Postsynapse Organization Cell Projection Organization CD40 Receptor Complex Anterograde Dendritic Transport JUN Kinase Binding Regulation Of Phosphorus Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of Phosphorylation Photoreceptor Connecting Cilium Kinesin Binding Kinesin Complex Establishment Of Vesicle Localization Cytoplasm	Polyubiquitin Modification-dependent Protein Binding Regulation Of Protein Catabolic Process Positive Regulation Of ERAD Pathway Regulation Of Proteasomal Protein Catabolic Process Regulation Of ERAD Pathway Regulation Of Cellular Response To Stress Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Protein Localization To Cell Cortex Regulation Of Proteolysis Regulation Of Macroautophagy Positive Regulation Of Protein Catabolic Process Regulation Of Protein Localization To Cell Cortex Autophagosome Organelle Organization Autophagosome Assembly Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Positive Regulation Of Catabolic Process Myosin V Binding Autophagosome Organization Autophagy Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Metabolic Process Cytosol Regulation Of Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Spectrin Binding Regulation Of Autophagy Perinuclear Region Of Cytoplasm Cortical Actin Cytoskeleton Organization Negative Regulation Of Transport Vacuole Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Establishment Of Protein Localization Trans-Golgi Network Cytoplasmic Vesicle Exocytosis Positive Regulation Of Proteolysis Cortical Cytoskeleton Organization Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MRNA 3'-end Processing Peptidyl-cysteine Methylation Negative Regulation Of Store-operated Calcium Channel Activity Response To Endoplasmic Reticulum Stress Regulation Of Vesicle-mediated Transport Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process
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