MLN and TTC19

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MLN	TTC19
Description		motilin	tetratricopeptide repeat domain 19
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Mitochondrion Mitochondrial Inner Membrane Centrosome Membrane Midbody
	Molecular Function	Hormone Activity Protein Binding Motilin Receptor Binding	Protein Binding
	Biological Process	Signal Transduction	Mitotic Cytokinesis Mitochondrial Respiratory Chain Complex III Assembly Cell Division
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	Complex III assembly
Drugs
Diseases			Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Alzheimer's disease (age of onset) ( 22005931) Asthma and attention deficit hyperactivity disorder ( 31619474) Birth weight ( 31043758) Blood protein levels ( 30072576) Body mass index ( 26426971) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease ( 23850713) Gastroesophageal reflux disease ( 34187846) Hand grip strength ( 29691431) Multisite chronic pain ( 31194737 33830993) Obesity (extreme) ( 19553259) Obesity-related traits ( 23251661) Phosphorus levels ( 20558539) Regular attendance at a gym or sports club ( 29970889)
Interacting Genes		3 interacting genes: MLNR TMX2 TTC19	44 interacting genes: AGXT APRT ATXN1 CCDC33 CHMP4A CIMIP1 COA6 CYSLTR2 DMRT3 EIF4ENIF1 FAM136A FAM217B FH FTO GORASP2 GPANK1 HOXD12 HPS6 IHO1 L3MBTL3 LDB2 MLN MXRA8 NAB2 NME4 POU6F2 PRR35 RBP1 REL RUSC1 RXFP3 SH2D4A SHISA6 SLC67A1-AS SMG9 SPRED1 TBX2 TCAP UBA1 UPF3B USP20 USP54 WASHC1 ZNF688
Entrez ID		4295	54902
HPRD ID		15931	07899
Ensembl ID		ENSG00000096395	ENSG00000011295
Uniprot IDs		P12872	Q6DKK2
PDB IDs		1LBJ 8IBV
Enriched GO Terms of Interacting Partners?		Disulfide Oxidoreductase Activity Mitochondrial Respiratory Chain Complex III Assembly Hormone Binding Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site G Protein-coupled Peptide Receptor Activity Cytochrome Complex Assembly
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