ALKBH8

Description		alkB homolog 8, tRNA methyltransferase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	TRNA Binding Nucleic Acid Binding RNA Binding Catalytic Activity Iron Ion Binding Protein Binding Methyltransferase Activity Zinc Ion Binding S-adenosylmethionine-dependent Methyltransferase Activity TRNA (uridine) Methyltransferase Activity 2-oxoglutarate-dependent Dioxygenase Activity Transferase Activity Metal Ion Binding Transition Metal Ion Binding TRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase Activity
	Biological Process	TRNA Wobble Uridine Modification DNA Damage Response TRNA Methylation Methylation
Pathways		tRNA modification in the nucleus and cytosol
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Large artery stroke ( 24262325)
Interacting Genes		3 interacting genes: APP MFAP1 PICK1
Entrez ID		91801
HPRD ID		14287
Ensembl ID		ENSG00000137760
Uniprot IDs		Q96BT7
PDB IDs		2CQ2 3THP 3THT
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Receptor Internalization Neuron Projection Organization Positive Regulation Of Receptor-mediated Endocytosis G Protein-coupled Receptor Binding Regulation Of Receptor Internalization Glial Cell Development Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Trans-Golgi Network Membrane Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Receptor-mediated Endocytosis Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Synaptic Plasticity Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Positive Regulation Of Endocytosis Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Membrane Curvature Sensor Activity Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Regulation Of Endocytosis Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Neuron Projection Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Negative Regulation Of Actin Nucleation Regulation Of Supramolecular Fiber Organization
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