MATN3

Description		matrilin 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Lumen Extracellular Matrix Matrilin Complex
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding
	Biological Process	Skeletal System Development Extracellular Matrix Organization Cartilage Development
Pathways		ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases		SEMD, Matrilin type; Spondyloepimetaphyseal dysplasia Multiple epiphyseal dysplasia (MED)
GWAS		Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172)
Interacting Genes		6 interacting genes: INCA1 KRTAP10-8 MATN1 MATN4 NOTCH2NLA TCF4
Entrez ID		4148
HPRD ID		03661
Ensembl ID		ENSG00000132031
Uniprot IDs		O15232
PDB IDs
Enriched GO Terms of Interacting Partners?		Matrilin Complex Growth Plate Cartilage Chondrocyte Morphogenesis Calcium Ion Binding Beta-catenin-TCF7L2 Complex TFIIB-class Transcription Factor Binding Extracellular Structure Organization Extracellular Matrix Organization Cartilage Morphogenesis Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cyclin-dependent Protein Kinase Activity Beta-catenin-TCF Complex Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
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