MAK and ANAPC11

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		MAK	ANAPC11
Gene Name		male germ cell-associated kinase	anaphase promoting complex subunit 11
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Nucleus Cytoplasm Centrosome Midbody Mitotic Spindle	Nucleoplasm Anaphase-promoting Complex Nucleolus Cytosol
	Molecular Function	Transcription Coactivator Activity Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity Cullin Family Protein Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Multicellular Organismal Development Spermatogenesis Cell Differentiation Photoreceptor Cell Maintenance Protein Autophosphorylation Regulation Of Cell Cycle	Mitotic Cell Cycle Mitotic Nuclear Division Mitotic Spindle Assembly Checkpoint Protein Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Protein K11-linked Ubiquitination
Pathways			Phosphorylation of the APC/C APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex Cellular Senescence Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Inactivation of APC/C via direct inhibition of the APC/C complex Autodegradation of Cdh1 by Cdh1:APC/C Mitotic Spindle Checkpoint Class I MHC mediated antigen processing & presentation Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Senescence-Associated Secretory Phenotype (SASP) Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins APC/C:Cdc20 mediated degradation of Cyclin B Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ANAPC11 APP FZR1 NDUFB7 PPP2CB SERINC1 SLAMF7 SND1	27 interactors: ANAPC1 ANAPC10 ANAPC2 CAPN11 CCNB1 CDC16 CDC25A CDC34 CDH1 CUL5 FBXO5 HECW2 KIF18A MAK MLKL NKD2 PTTG1 RNF111 TRIM65 UBC UBE2C UBE2D1 UBE2D2 UBE2K UBE2S UBE2U ZAP70
Entrez ID		4117	51529
HPRD ID		01101	12452
Ensembl ID		ENSG00000111837	ENSG00000141552
Uniprot IDs		F8VBW7 P20794	Q9NYG5
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein K11-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Proteolysis Involved In Cellular Protein Catabolic Process Synaptic Growth At Neuromuscular Junction Positive Regulation Of Transferase Activity Cellular Protein Catabolic Process Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Catalytic Activity Collateral Sprouting In Absence Of Injury Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Cellular Protein Catabolic Process Protein Polyubiquitination Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Catalytic Activity Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Ubiquitination Activation Of Anaphase-promoting Complex Activity Axon Choice Point Recognition Cellular Macromolecule Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Regulation Of Cell Cycle Regulation Of Cell Division Neuron Remodeling Negative Regulation Of Transferase Activity L-serine Transport Mitotic Nuclear Division	Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Protein Ubiquitination Protein Modification By Small Protein Conjugation Proteolysis Mitotic Cell Cycle Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Mitotic Cell Cycle Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Protein K11-linked Ubiquitination Catabolic Process Mitotic Nuclear Division Positive Regulation Of Protein Catabolic Process Cell Cycle Process Negative Regulation Of Protein Ubiquitination Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Cellular Protein Modification Process Regulation Of Chromosome Segregation Cell Cycle Regulation Of Proteolysis Regulation Of Mitotic Sister Chromatid Separation Protein Metabolic Process Cell Division Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Negative Regulation Of Cellular Protein Catabolic Process
Tagcloud ?		20e ab11 acari amblyomma basepair comp ecdysone ecdysteroid ecdysteroids ecr ecre ecres endocrinol hebraeum heterodimerized hsp27 ixodid ixodidae kaufman koch mcblain mur palindrome pon ponasterone salivary supershifted tick usp	afg3l2 arf1 calgizzarin cki dci dph2l fb1 fxyd6 gif gp96 gpr85 hhp2 kpdxm ksp mrps7 ohs osteosarcomas ought p110 phosphoglucoisomerase rpl13a rpl35a s11 sec34 skd3 subtracted subtractive sulphonase tapa
Tagcloud (Difference) ?		20e ab11 acari amblyomma basepair comp ecdysone ecdysteroid ecdysteroids ecr ecre ecres endocrinol hebraeum heterodimerized hsp27 ixodid ixodidae kaufman koch mcblain mur palindrome pon ponasterone salivary supershifted tick usp	afg3l2 arf1 calgizzarin cki dci dph2l fb1 fxyd6 gif gp96 gpr85 hhp2 kpdxm ksp mrps7 ohs osteosarcomas ought p110 phosphoglucoisomerase rpl13a rpl35a s11 sec34 skd3 subtracted subtractive sulphonase tapa
Tagcloud (Intersection) ?