MAGEA8 and PKD2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		MAGEA8	PKD2
Description		MAGE family member A8	polycystin 2, transient receptor potential cation channel
Image
GO Annotations	Cellular Component	Nucleus	Polycystin Complex Extracellular Region Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Cell-cell Junction Cilium Basal Plasma Membrane Membrane Basolateral Plasma Membrane Lamellipodium Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Motile Cilium Vesicle Monoatomic Ion Channel Complex Cation Channel Complex Ciliary Basal Body Cell Projection Basal Cortex Ciliary Membrane Extracellular Exosome Mitotic Spindle Non-motile Cilium Lumenal Side Of Endoplasmic Reticulum Membrane Cytoplasmic Side Of Endoplasmic Reticulum Membrane Migrasome
	Molecular Function	Protein Binding Histone Deacetylase Binding	Signaling Receptor Binding Voltage-gated Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Voltage-gated Sodium Channel Activity Voltage-gated Potassium Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Potassium Channel Activity Sodium Channel Activity Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Channel Activity Outward Rectifier Potassium Channel Activity Voltage-gated Monoatomic Cation Channel Activity Identical Protein Binding Protein Homodimerization Activity Actinin Binding HLH Domain Binding Transmembrane Transporter Binding Metal Ion Binding Calcium-induced Calcium Release Activity ATPase Binding Phosphoprotein Binding Muscle Alpha-actinin Binding Transcription Regulator Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II	Branching Involved In Ureteric Bud Morphogenesis Kidney Development Liver Development Embryonic Placenta Development Heart Looping Detection Of Nodal Flow Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Determination Of Left/right Symmetry Heart Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Wnt Signaling Pathway Calcium-mediated Signaling Spinal Cord Development Neural Tube Development Monoatomic Ion Transmembrane Transport Cellular Response To Reactive Oxygen Species Metanephric Part Of Ureteric Bud Development Sodium Ion Transmembrane Transport Aorta Development Regulation Of Cell Population Proliferation Chordate Embryonic Development Cilium Organization Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Detection Of Mechanical Stimulus Release Of Sequestered Calcium Ion Into Cytosol Protein Tetramerization Protein Homotetramerization Protein Heterotetramerization Centrosome Duplication Establishment Of Localization In Cell Regulation Of Cell Cycle Placenta Blood Vessel Development Renal Tubule Morphogenesis Renal Artery Morphogenesis Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Cellular Response To CAMP Cellular Response To Hydrostatic Pressure Cellular Response To Osmotic Stress Cellular Response To Fluid Shear Stress Potassium Ion Transmembrane Transport Determination Of Liver Left/right Asymmetry Metanephric Mesenchyme Development Mesonephric Tubule Development Mesonephric Duct Development Metanephric Smooth Muscle Tissue Development Metanephric Cortex Development Metanephric Ascending Thin Limb Development Metanephric Cortical Collecting Duct Development Metanephric Distal Tubule Development Metanephric S-shaped Body Morphogenesis Regulation Of Calcium Ion Import Inorganic Cation Transmembrane Transport Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium
Drugs
Diseases			Polycystic kidney disease
GWAS			Coffee consumption (cups per day) ( 25288136) Dental caries ( 23064961) Gout ( 30899057) Hyperuricemia ( 28776340) Serum alkaline phosphatase levels ( 33547301) Serum uric acid levels in response to allopurinol in gout ( 25676789) Uric acid levels ( 29558500)
Interacting Genes		15 interacting genes: BEX5 CCDC59 GCA LMO2 LXN MAGEB4 MLH1 MTUS2 PKD2 TDRD7 UBE3A WT1 ZNF221 ZNF224 ZNF417	21 interacting genes: ACTN2 CD2AP CYSRT1 DIAPH1 HAX1 HSF2BP KRT40 KRTAP10-3 KRTAP10-8 KRTAP6-2 LMNA MAGEA8 MDFI PACS1 PACS2 PKD1 PLSCR1 PTPRG TNNI3 TPM1 TRPC1
Entrez ID		4107	5311
HPRD ID		02278	01437
Ensembl ID		ENSG00000156009	ENSG00000118762
Uniprot IDs		B2R9W4 P43361	Q13563 Q9UEU6
PDB IDs		8FJB	2KLD 2KLE 2KQ6 2Y4Q 3HRN 3HRO 5K47 5MKE 5MKF 5T4D 6A70 6D1W 6T9N 6T9O 6WB8 8HK7 8K3S 9DLI 9DWQ
Enriched GO Terms of Interacting Partners?		Metanephric S-shaped Body Morphogenesis S-shaped Body Morphogenesis Metanephric Mesenchyme Development Metanephric Epithelium Development Renal Tubule Morphogenesis Regulation Of Transcription By RNA Polymerase II Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Branching Involved In Ureteric Bud Morphogenesis Metanephric Cortical Collecting Duct Development Metanephric Cortex Development Metanephric Distal Tubule Development Mesonephric Epithelium Development Mesonephric Tubule Development Sperm Entry Positive Regulation Of Golgi Lumen Acidification Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Regulation Of Nucleobase-containing Compound Metabolic Process Metal Ion Binding Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Chiasma Polycystin Complex Metanephric Smooth Muscle Tissue Development Cellular Response To CAMP Mesenchyme Development Renal Artery Morphogenesis Kidney Epithelium Development Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Male Meiosis Chromosome Segregation MutLalpha Complex Cellular Response To Hydrostatic Pressure Detection Of Nodal Flow Regulation Of Golgi Lumen Acidification Negative Regulation Of Female Gonad Development Negative Regulation Of Glomerular Mesangial Cell Proliferation Response To CAMP Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Guanine/thymine Mispair Binding Homologous Chromosome Segregation	Transmembrane Transporter Binding Intermediate Filament Actin Filament Sarcomere Alcohol Dehydrogenase (NAD+) Activity Actin Filament Binding Striated Muscle Cell Development Regulation Of Cytoskeleton Organization Actin Binding Cytosol All-trans-retinol Dehydrogenase (NAD+) Activity Cation Channel Complex Actin-myosin Filament Sliding Muscle Filament Sliding Protein Domain Specific Binding Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Keratin Filament Muscle Cell Development Structural Constituent Of Cytoskeleton Regulation Of Muscle System Process Positive Regulation Of Cation Transmembrane Transport Regulation Of Monoatomic Cation Transmembrane Transport Retinoic Acid Metabolic Process Protein Heterooligomerization Actin Cytoskeleton Positive Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Biological Quality Actin Filament Uncapping Identical Protein Binding Butanol Dehydrogenase (NAD+) Activity Ethanol Dehydrogenase (NAD+) Activity Actin Filament Polymerization Regulation Of Calcium Ion Transmembrane Transport Regulation Of System Process S-methyl-5-thioadenosine Phosphorylase Activity Metanephric Distal Tubule Morphogenesis Monoatomic Cation Channel Activity Regulation Of ATP-dependent Activity Negative Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Cell Proliferation Involved In Kidney Morphogenesis Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Positive Regulation Of Heart Rate By Epinephrine Actin-mediated Cell Contraction
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