ASIC1 and STOM

Number of citations of the paper that reports this interaction (PubMedID 15471860)
0

Data Source:
HPRD (in vivo)

		ASIC1	STOM
Description		acid sensing ion channel subunit 1	stomatin
Image
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Cell Surface Membrane Dendrite Cell Projection Synapse Postsynaptic Membrane Presynapse Postsynaptic Density Membrane Glutamatergic Synapse	Extracellular Space Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Cytoskeleton Plasma Membrane Membrane Cytoplasmic Vesicle Vesicle Azurophil Granule Membrane Specific Granule Membrane Melanosome Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Tertiary Granule Membrane Blood Microparticle
	Molecular Function	Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Sodium Channel Activity Protein Binding Ligand-gated Sodium Channel Activity Monoatomic Ion-gated Channel Activity Inorganic Cation Transmembrane Transporter Activity PH-gated Monoatomic Ion Channel Activity	Protein Binding Ion Channel Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity RNA Polymerase Binding
	Biological Process	Behavioral Fear Response Response To Amphetamine Monoatomic Ion Transport Monoatomic Cation Transport Sodium Ion Transport Calcium Ion Transport Neurotransmitter Secretion Memory Associative Learning Response To Acidic PH Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Negative Regulation Of Neurotransmitter Secretion Sensory Perception Of Sour Taste Establishment Of Localization In Cell Calcium Ion Transmembrane Transport Cellular Response To PH Inorganic Cation Transmembrane Transport Regulation Of Postsynapse Assembly	Regulation Of Monoatomic Ion Transmembrane Transport Host-mediated Activation Of Viral Genome Replication Positive Regulation Of Viral Process Positive Regulation Of Protein Targeting To Membrane
Pathways		Stimuli-sensing channels	Stimuli-sensing channels Neutrophil degranulation RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOJ GTPase cycle
Drugs		Amiloride
Diseases			Hereditary stomatocytosis (HSt); Dehydrated hereditary stomatocytosis (DHS); Overhydrated hereditary stomatocytosis (OHS); Familial pseudohyperkalemia (FP)
GWAS
Interacting Genes		7 interacting genes: ASIC2 ATXN3 KIR3DL3 MGST2 PICK1 PRKACA STOM	81 interacting genes: AIG1 APOA2 ASIC1 ASIC2 ASIC3 ATP1B3 ATP6V0B ATP6V0C BCL2L2 BNIP1 C2 C3orf52 CFHR5 CHST1 CLDN19 CLRN2 CMTM5 CNIH3 CTXN3 CYB5B CYB5R3 DAGLA DVL3 EMP1 ERG28 FAXDC2 FUNDC2 GIMAP1 GIMAP5 GPR25 GPR37L1 GRM2 HMOX2 KCNK1 KTN1 LANCL1 LNPEP MGLL MMP14 NKG7 ORMDL1 PEDS1-UBE2V1 PEMT PGA4 PMP22 PTCH1 RPL13A RPRM RTP2 RUVBL1 RUVBL2 SCD SELENOK SERP2 SFT2D1 SFT2D2 SFXN1 SFXN5 SLC2A1 SLC35B4 SMCO4 STX6 TECR THSD7B TMEM109 TMEM120B TMEM140 TMEM14B TMEM203 TMEM208 TMEM254 TMEM60 TMEM86B TMEM98 TMPO TNF TNFRSF10C TSPO2 VAMP4 WFDC2 YIPF6
Entrez ID		41	2040
HPRD ID		04182	00585
Ensembl ID		ENSG00000110881	ENSG00000148175
Uniprot IDs		A8K1U5 P78348	F8VSL7 P27105
PDB IDs		6L6I 6L6N 7CFS 7CFT 7RNN	7WH3
Enriched GO Terms of Interacting Partners?		Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Systemic Arterial Blood Pressure By Aortic Arch Baroreceptor Feedback Plasma Membrane Regulation Of Monoatomic Ion Transport Negative Regulation Of TORC1 Signaling Response To Heat Protein Localization To Cytosolic Proteasome Complex TOR Signaling Cellular Response To Nutrient Levels TORC1 Signaling Cellular Response To Heat Negative Regulation Of TOR Signaling PH-gated Sodium Channel Activity Monoatomic Ion-gated Channel Activity Response To Nutrient Levels Regulation Of TORC1 Signaling Regulation Of Establishment Of Protein Localization Membrane Regulation Of TOR Signaling Response To Temperature Stimulus Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Membrane Curvature Sensor Activity Cell Communication Positive Regulation Of Endocytosis Sensory Perception Of Sour Taste Regulation Of Blood Circulation Regulation Of Cell Junction Assembly Intracellular Protein Localization Regulation Of Transport Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Ligand-gated Sodium Channel Activity Synapse Perinuclear Region Of Cytoplasm Host-mediated Perturbation Of Viral Genome Replication Identical Protein Binding Host-mediated Activation Of Viral Genome Replication Regulation Of Protein Localization Glutathione Binding Leukotriene-C4 Synthase Activity Cellular Response To Starvation Monoubiquitinated Protein Deubiquitination Nuclear Inclusion Body Response To Starvation Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Misfolded Protein CAMP-dependent Protein Kinase Complex Regulation Of Hormone Secretion Regulation Of Peptide Hormone Secretion Cellular Response To Parathyroid Hormone Stimulus	Membrane Endoplasmic Reticulum Membrane Sensory Perception Of Sour Taste Endoplasmic Reticulum Response To Acidic PH Sodium Channel Activity PH-gated Sodium Channel Activity Monoatomic Ion-gated Channel Activity Ligand-gated Sodium Channel Activity Protein Binding Cellular Response To Type II Interferon Response To PH PH-gated Monoatomic Ion Channel Activity Nitric-oxide Synthase Complex Synaptic Vesicle To Endosome Fusion Mitochondrial Outer Membrane Response To Type II Interferon Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Nitrite Reductase (NO-forming) Activity R2TP Complex Cellular Response To PH Detection Of Mechanical Stimulus Involved In Sensory Perception Acylglycerol Catabolic Process Diacylglycerol Catabolic Process Lipid Biosynthetic Process Amino Acid Transport Organic Anion Transport Telomerase RNA Localization To Cajal Body Sensory Perception Of Taste Response To Mechanical Stimulus Plasma Membrane
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