ASIC1 and ASIC2

Number of citations of the paper that reports this interaction (PMID 9360943)
43

Data Source:
HPRD (in vitro, in vivo)

		ASIC1	ASIC2
Gene Name		acid sensing (proton gated) ion channel 1	acid sensing (proton gated) ion channel 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane Neuronal Cell Body Dendritic Spine Synapse
	Molecular Function	Protein Binding Ligand-gated Sodium Channel Activity Acid-sensing Ion Channel Activity	Voltage-gated Sodium Channel Activity Protein Binding Ligand-gated Sodium Channel Activity Ion Gated Channel Activity
	Biological Process	Transport Sodium Ion Transport Calcium Ion Transport Signal Transduction Response To PH Ion Transmembrane Transport Sodium Ion Transmembrane Transport Sensory Perception Of Sour Taste Transmembrane Transport Protein Homotrimerization Cellular Response To PH	Regulation Of Systemic Arterial Blood Pressure By Aortic Arch Baroreceptor Feedback Synaptic Transmission Central Nervous System Development Peripheral Nervous System Development Phototransduction Sensory Perception Of Sound Regulation Of Gene Expression Monovalent Inorganic Cation Transport Regulation Of Vasoconstriction Regulation Of Blood Coagulation Ion Transmembrane Transport Protein Localization To Synapse Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Negative Regulation Of Apoptotic Process Sensory Perception Of Sour Taste Detection Of Mechanical Stimulus Involved In Sensory Perception Positive Regulation Of Synapse Assembly Transmembrane Transport Cellular Response To Acid Chemical Cellular Response To Acidic PH Positive Regulation Of Cation Channel Activity
Pathways		Ion channel transport Stimuli-sensing channels	Ion channel transport Stimuli-sensing channels
Drugs		Diclofenac Amiloride	Amiloride
Diseases
GWAS
Protein-Protein Interactions		5 interactors: ASIC2 ATXN3 PICK1 PRKACA STOM	4 interactors: ASIC1 ASIC3 PICK1 STOM
Entrez ID		41	40
HPRD ID		04182	03471
Ensembl ID		ENSG00000110881	ENSG00000108684
Uniprot IDs		A8K1U5 P78348	Q16515
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cation Channel Activity Synaptic Transmission Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Cell-cell Signaling Response To Abiotic Stimulus Regulation Of Ion Transmembrane Transport Phototransduction Regulation Of Blood Coagulation Regulation Of Ion Transport Detection Of Light Stimulus Regulation Of Systemic Arterial Blood Pressure By Aortic Arch Baroreceptor Feedback Positive Regulation Of Dense Core Granule Biogenesis Regulation Of Acid-sensing Ion Channel Activity Positive Regulation Of Transport Regulation Of Wound Healing Cell Maturation Histone H3-T6 Phosphorylation Nervous System Development Detection Of Abiotic Stimulus Sensory Perception Of Sour Taste Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning DNA Methylation Involved In Embryo Development Cellular Response To Acidic PH Regulation Of Synaptic Transmission Positive Regulation Of Cellular Component Biogenesis Desmosome Assembly Monoubiquitinated Protein Deubiquitination Dendritic Spine Maintenance Negative Regulation Of Glial Cell Apoptotic Process Response To Light Stimulus Regulation Of Tight Junction Assembly Negative Regulation Of Glucose Import Positive Regulation Of Macrophage Differentiation Neuronal Ion Channel Clustering Cell Communication By Electrical Coupling Involved In Cardiac Conduction Calcium-mediated Signaling Using Intracellular Calcium Source Desmosome Organization Response To Parathyroid Hormone Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Protein Export From Nucleus Misfolded Or Incompletely Synthesized Protein Catabolic Process Negative Regulation Of Actin Nucleation Cell Communication By Electrical Coupling Cellular Response To Misfolded Protein Cellular Response To PH	Sensory Perception Of Sour Taste Response To PH Sensory Perception Of Taste Enterobactin Transport Regulation Of Acid-sensing Ion Channel Activity Detection Of Chemical Stimulus Involved In Sensory Perception Of Pain Response To Abiotic Stimulus Sodium Ion Transmembrane Transport Siderophore Transport Sodium Ion Transport Protein Homooligomerization DNA Methylation Involved In Embryo Development Dendritic Spine Maintenance Sensory Perception Of Chemical Stimulus Neuronal Ion Channel Clustering Protein Oligomerization Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Actin Nucleation Cellular Response To PH Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Long Term Synaptic Depression Response To Acidic PH Protein Homotrimerization Positive Regulation Of Receptor Internalization Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Regulation Of Arp2/3 Complex-mediated Actin Nucleation Dendritic Spine Organization DNA Methylation Involved In Gamete Generation Regulation Of Actin Nucleation Cellular Response To Glucose Starvation Monoamine Transport Cellular Component Maintenance Monovalent Inorganic Cation Transport Detection Of Temperature Stimulus Regulation Of Sodium Ion Transmembrane Transporter Activity Neuron Maturation Regulation Of Receptor Internalization Sensory Perception Of Temperature Stimulus Protein Trimerization Regulation Of Sodium Ion Transmembrane Transport Detection Of Mechanical Stimulus Involved In Sensory Perception Retrograde Vesicle-mediated Transport, Golgi To ER Positive Regulation Of Receptor-mediated Endocytosis Sensory Perception Metal Ion Transport Detection Of Mechanical Stimulus Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Cation Transmembrane Transport Receptor Clustering DNA Methylation
Tagcloud ?		amiloride asic2a asic3 asics blocker currents cyclooxygenase defense elusive exact existed existence glia homomeric lipopolysaccharide meanwhile microglia microglial neuroinflammatory nonspecific participate pctx1 qpcr scavenger scrape sensing transcriptase
Tagcloud (Difference) ?		amiloride asic2a asic3 asics blocker currents cyclooxygenase defense elusive exact existed existence glia homomeric lipopolysaccharide meanwhile microglia microglial neuroinflammatory nonspecific participate pctx1 qpcr scavenger scrape sensing transcriptase
Tagcloud (Intersection) ?