ASIC1 and ASIC2

Number of citations of the paper that reports this interaction (PubMedID 9360943)
0

Data Source:
HPRD (in vitro, in vivo)

		ASIC1	ASIC2
Description		acid sensing ion channel subunit 1	acid sensing ion channel subunit 2
Image
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Cell Surface Membrane Dendrite Cell Projection Synapse Postsynaptic Membrane Presynapse Postsynaptic Density Membrane Glutamatergic Synapse	Plasma Membrane Membrane Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Postsynaptic Density Membrane
	Molecular Function	Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Sodium Channel Activity Protein Binding Ligand-gated Sodium Channel Activity Monoatomic Ion-gated Channel Activity Inorganic Cation Transmembrane Transporter Activity PH-gated Monoatomic Ion Channel Activity	Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Sodium Channel Activity Protein Binding Ligand-gated Sodium Channel Activity Monoatomic Ion-gated Channel Activity PH-gated Sodium Channel Activity
	Biological Process	Behavioral Fear Response Response To Amphetamine Monoatomic Ion Transport Monoatomic Cation Transport Sodium Ion Transport Calcium Ion Transport Neurotransmitter Secretion Memory Associative Learning Response To Acidic PH Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Negative Regulation Of Neurotransmitter Secretion Sensory Perception Of Sour Taste Establishment Of Localization In Cell Calcium Ion Transmembrane Transport Cellular Response To PH Inorganic Cation Transmembrane Transport Regulation Of Postsynapse Assembly	Regulation Of Systemic Arterial Blood Pressure By Aortic Arch Baroreceptor Feedback Monoatomic Ion Transport Monoatomic Cation Transport Sodium Ion Transport Synapse Assembly Phototransduction Sensory Perception Of Sound Response To Mechanical Stimulus Response To Acidic PH Regulation Of Vasoconstriction Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Protein Localization To Synapse Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Negative Regulation Of Apoptotic Process Sensory Perception Of Sour Taste Detection Of Mechanical Stimulus Involved In Sensory Perception Establishment Of Localization In Cell Positive Regulation Of Synapse Assembly Cellular Response To Xenobiotic Stimulus Cellular Response To Acidic PH Regulation Of Postsynapse Assembly
Pathways		Stimuli-sensing channels	Stimuli-sensing channels
Drugs		Amiloride	Amiloride
Diseases
GWAS			Adult body size ( 32376654) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Autism ( 30675382) Cerebellum cortex volume ( 31530798) Chronotype ( 30696823) Clopidogrel active metabolite levels ( 28207573) Congenital heart disease (septal defects) ( 33201861) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Longevity ( 26912274) Mosquito bite size ( 28199695) Plasma parathyroid hormone levels ( 30134803) Polycystic ovary syndrome ( 30343302) Serum bilirubin levels in metabolic syndrome ( 30621171) Severe gingival inflammation ( 28459102)
Interacting Genes		7 interacting genes: ASIC2 ATXN3 KIR3DL3 MGST2 PICK1 PRKACA STOM	4 interacting genes: ASIC1 ASIC3 PICK1 STOM
Entrez ID		41	40
HPRD ID		04182	03471
Ensembl ID		ENSG00000110881	ENSG00000108684
Uniprot IDs		A8K1U5 P78348	Q16515
PDB IDs		6L6I 6L6N 7CFS 7CFT 7RNN	6L6P
Enriched GO Terms of Interacting Partners?		Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Systemic Arterial Blood Pressure By Aortic Arch Baroreceptor Feedback Plasma Membrane Regulation Of Monoatomic Ion Transport Negative Regulation Of TORC1 Signaling Response To Heat Protein Localization To Cytosolic Proteasome Complex TOR Signaling Cellular Response To Nutrient Levels TORC1 Signaling Cellular Response To Heat Negative Regulation Of TOR Signaling PH-gated Sodium Channel Activity Monoatomic Ion-gated Channel Activity Response To Nutrient Levels Regulation Of TORC1 Signaling Regulation Of Establishment Of Protein Localization Membrane Regulation Of TOR Signaling Response To Temperature Stimulus Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Membrane Curvature Sensor Activity Cell Communication Positive Regulation Of Endocytosis Sensory Perception Of Sour Taste Regulation Of Blood Circulation Regulation Of Cell Junction Assembly Intracellular Protein Localization Regulation Of Transport Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Ligand-gated Sodium Channel Activity Synapse Perinuclear Region Of Cytoplasm Host-mediated Perturbation Of Viral Genome Replication Identical Protein Binding Host-mediated Activation Of Viral Genome Replication Regulation Of Protein Localization Glutathione Binding Leukotriene-C4 Synthase Activity Cellular Response To Starvation Monoubiquitinated Protein Deubiquitination Nuclear Inclusion Body Response To Starvation Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Misfolded Protein CAMP-dependent Protein Kinase Complex Regulation Of Hormone Secretion Regulation Of Peptide Hormone Secretion Cellular Response To Parathyroid Hormone Stimulus	PH-gated Monoatomic Ion Channel Activity Sensory Perception Of Sour Taste Ligand-gated Sodium Channel Activity Response To Acidic PH Sensory Perception Of Taste Sodium Channel Activity Monoatomic Cation Channel Activity Response To PH Establishment Of Localization In Cell Enterobactin Transport Enterobactin Transmembrane Transporter Activity Sensory Perception Of Chemical Stimulus Sodium Ion Transmembrane Transport Monoatomic Ion-gated Channel Activity PH-gated Sodium Channel Activity Siderophore Transport Detection Of Chemical Stimulus Involved In Sensory Perception Of Pain Sodium Ion Transport Membrane Curvature Sensor Activity Plasma Membrane Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Neurotransmitter Secretion Inorganic Cation Transmembrane Transporter Activity Negative Regulation Of Actin Nucleation Negative Regulation Of Telomere Capping Host-mediated Perturbation Of Viral Genome Replication Host-mediated Activation Of Viral Genome Replication Neuronal Ion Channel Clustering Dendritic Spine Maintenance Ion Channel Inhibitor Activity Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Arp2/3 Complex Binding Regulation Of Telomere Capping Long-term Synaptic Depression Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Sensory Perception Regulation Of Transport Cellular Response To PH Regulation Of Membrane Potential Modulation Of Chemical Synaptic Transmission Positive Regulation Of Protein Targeting To Membrane RNA Polymerase Binding Detection Of Mechanical Stimulus Involved In Sensory Perception Detection Of Temperature Stimulus Involved In Sensory Perception Detection Of Temperature Stimulus Positive Regulation Of Receptor Internalization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Exon-exon Junction Complex Telomerase RNA Binding Telomeric DNA Binding
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