MLX and MLXIPL

Number of citations of the paper that reports this interaction (PMID 14742444)
36

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		MLX	MLXIPL
Gene Name		MLX, MAX dimerization protein	MLX interacting protein-like
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Homodimerization Activity Protein Heterodimerization Activity	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Factor Binding Carbohydrate Response Element Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Energy Reserve Metabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Nucleocytoplasmic Transport Positive Regulation Of Cellular Metabolic Process Small Molecule Metabolic Process Negative Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter Energy Reserve Metabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Proliferation Anatomical Structure Morphogenesis Glucose Mediated Signaling Pathway Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Peptidyl-serine Phosphorylation Intracellular Signal Transduction Regulation Of Fatty Acid Biosynthetic Process Glucose Homeostasis Small Molecule Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Glycolytic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Lipid Biosynthetic Process Fatty Acid Homeostasis Triglyceride Homeostasis Negative Regulation Of Cell Cycle Arrest Cellular Response To Carbohydrate Stimulus Negative Regulation Of Oxidative Phosphorylation Regulation Of Energy Homeostasis
Pathways		Integration of energy metabolism ChREBP activates metabolic gene expression	PP2A-mediated dephosphorylation of key metabolic factors Integration of energy metabolism ChREBP activates metabolic gene expression PKA-mediated phosphorylation of key metabolic factors AMPK inhibits chREBP transcriptional activation activity
Drugs
Diseases
GWAS		Crohn's disease ( 21102463)	HDL cholesterol ( 20686565) Hypertriglyceridemia ( 23505323 20657596) Lipid metabolism phenotypes ( 22286219) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Metabolic syndrome ( 22399527) Triglycerides ( 21909109 18193043 18193044 18193046 20864672 19060906 19060911 20686565) Urate levels ( 23263486)
Protein-Protein Interactions		13 interactors: AES APP GABARAPL2 ID3 MAD1L1 MLXIP MLXIPL MNT MXD1 MXD4 RBM39 SAP30BP ZBTB32	3 interactors: GRB2 MLX NIF3L1
Entrez ID		6945	51085
HPRD ID		04278	12033
Ensembl ID		ENSG00000108788	ENSG00000009950
Uniprot IDs		Q9UH92	Q9NP71
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Cell Cycle Regulation Of Cellular Process Cellular Metabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Carbohydrate Metabolic Process By Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metaphase Plate Congression Glucose Mediated Signaling Pathway Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Protein Metabolic Process Synaptic Growth At Neuromuscular Junction Regulation Of Protein Processing Carbohydrate Mediated Signaling Collateral Sprouting In Absence Of Injury Negative Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Oxidative Phosphorylation Positive Regulation Of Anoikis Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Protein Binding	7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Dihydrobiopterin Metabolic Process
Tagcloud ?		accumulate acetyltransferase adapt bhlhzip circuitry defective fitness fundamental glucose helix homeostasis intracellular leucine mechanistic mondoa next occupancy organismal requirement respond sense simply steps stimulate stimulates transcriptionally trigger underlies zipper	adipogenic adipokines calving cebpa cebpb chrebp crebbp dgat2 fo hydroxybutyrate lcfa lipogenesis lipogenic lpin1 med1 ncoa1 ncor2 nfkb1 nonesterified nrip1 parturition peripartal postpartal prepartal prepartum rxra scd sfat triacylglycerol
Tagcloud (Difference) ?		accumulate acetyltransferase adapt bhlhzip circuitry defective fitness fundamental glucose helix homeostasis intracellular leucine mechanistic mondoa next occupancy organismal requirement respond sense simply steps stimulate stimulates transcriptionally trigger underlies zipper	adipogenic adipokines calving cebpa cebpb chrebp crebbp dgat2 fo hydroxybutyrate lcfa lipogenesis lipogenic lpin1 med1 ncoa1 ncor2 nfkb1 nonesterified nrip1 parturition peripartal postpartal prepartal prepartum rxra scd sfat triacylglycerol
Tagcloud (Intersection) ?