MLX and MLXIPL

Number of citations of the paper that reports this interaction (PubMedID 11230181)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		MLX	MLXIPL
Description		MAX dimerization protein MLX	MLX interacting protein like
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Membrane	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Carbohydrate Response Element Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Lipid Biosynthetic Process Anatomical Structure Morphogenesis Glucose Mediated Signaling Pathway Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Glucose Homeostasis Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Glycolytic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Lipid Biosynthetic Process Fatty Acid Homeostasis Triglyceride Homeostasis Negative Regulation Of Oxidative Phosphorylation Energy Homeostasis Negative Regulation Of Signal Transduction By P53 Class Mediator
Pathways		ChREBP activates metabolic gene expression ChREBP activates metabolic gene expression	PKA-mediated phosphorylation of key metabolic factors PKA-mediated phosphorylation of key metabolic factors AMPK inhibits chREBP transcriptional activation activity ChREBP activates metabolic gene expression ChREBP activates metabolic gene expression PP2A-mediated dephosphorylation of key metabolic factors
Drugs
Diseases
GWAS		Crohn's disease ( 21102463) Type 2 diabetes ( 29632382 30297969 30718926) Type 2 diabetes (time to event) ( 32589924) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	A body shape index ( 34021172) Alanine aminotransferase levels ( 33547301) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Apolipoprotein B levels ( 32203549) Birth weight ( 27680694 31043758) Bitter alcoholic beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Coffee consumption ( 31046077 31959922) Coffee consumption (cups per day) ( 25288136 31837886) Eosinophil percentage of white cells ( 32888494) Factor VII activity ( 30642921) Gamma glutamyl transferase levels ( 29403010 33339817) Glycated hemoglobin levels ( 34059833) HDL cholesterol ( 20686565 24097068 30275531) HDL cholesterol levels ( 28334899 30698716 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Hypertriglyceridemia ( 20657596 23505323 27599772) Immature fraction of reticulocytes ( 32888494) Lamb consumption ( 32066663) LDL levels x fish oil supplementation interaction (1df) ( 33760818) LDL levels x fish oil supplementation interaction (2df) ( 33760818) Lipid metabolism phenotypes ( 22286219) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757 33972514) Low density lipoprotein cholesterol levels ( 32154731) Malaria ( 31844061) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Meat-related diet ( 32066663) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 22399527) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Non-oily fish consumption ( 32066663) Platelet count ( 27863252) Platelet distribution width ( 32888494) Postprandial triglyceride levels ( 32603185) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Serum albumin levels ( 29403010) Serum alkaline phosphatase levels ( 33547301) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Serum uric acid levels ( 29403010 30993211) Total cholesterol levels ( 30275531) Total triglycerides levels ( 26690388) Triglyceride levels ( 28334899 29403010 30698716 31087446 32154731 33339817) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 18193043 18193044 18193046 19060906 19060911 20686565 20864672 21909109 24097068 25961943 26160806 26582766 30275531) Urate levels ( 23263486 31578528) Urinary sodium excretion ( 31409800) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) White blood cell count ( 32888494)
Interacting Genes		31 interacting genes: APP BACH2 BEND7 CASK CCT6A DDIT4L GABARAPL1 GABARAPL2 ID3 KRTAP13-3 LNX1 LNX2 MAD1L1 MEI4 MEOX1 MEOX2 MLXIP MLXIPL MNT MXD1 MXD4 PIAS2 RBM39 RHBDD2 SAP30BP TEPSIN TLE5 TNNT2 UBE2I ZBTB32 ZNF620	4 interacting genes: EP300 GRB2 MLX NIF3L1
Entrez ID		6945	51085
HPRD ID		04278	12033
Ensembl ID		ENSG00000108788	ENSG00000009950
Uniprot IDs		Q9UH92	Q9NP71
PDB IDs			6MJL 6YGJ 8BTQ 8BWE 8BWH 8C1Y
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II Protein Dimerization Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process DNA Binding Somite Specification RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Cellular Response To Nitrogen Starvation Regulation Of Macromolecule Metabolic Process Phosphatidylethanolamine Binding Regulation Of Gene Expression Segment Specification Somite Development GABA Receptor Binding Positive Regulation Of ATP-dependent Activity SUMO Transferase Activity Regulation Of Metabolic Process Positive Regulation Of Glycolytic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To Leptomycin B Leptomycin B Binding Regulation Of ATP-dependent Activity SUMO Conjugating Enzyme Activity MAD1 Complex Carbohydrate Response Element Binding Primary Adaptive Immune Response Involving T Cells And B Cells Coated Vesicle Membrane Positive Regulation Of ATP Metabolic Process Negative Regulation Of Metabolic Process	RNA Polymerase II-specific DNA-binding Transcription Factor Binding Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Transcription Coactivator Binding Endodermal Cell Differentiation Guanyl-nucleotide Exchange Factor Adaptor Activity Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity SH3 Domain Binding Grb2-EGFR Complex N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Thigmotaxis Peptide Lactyltransferase (CoA-dependent) Activity Negative Regulation Of Protein Oligomerization Cellular Response To Radiation
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