MLX and MLXIP

Number of citations of the paper that reports this interaction (PubMedID 12446771)
61

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		MLX	MLXIP
Description		MAX dimerization protein MLX	MLX interacting protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Membrane	Chromatin Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Membrane
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		ChREBP activates metabolic gene expression ChREBP activates metabolic gene expression
Drugs
Diseases
GWAS		Crohn's disease ( 21102463) Type 2 diabetes ( 29632382 30297969 30718926) Type 2 diabetes (time to event) ( 32589924) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	A body shape index ( 34021172) Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) ( 23648065) Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Body mass index ( 29273807) Diastolic blood pressure ( 30224653) Gout ( 32238385 33832965) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Red blood cell count ( 32888494) Serum uric acid levels ( 30993211) Urate levels ( 31578528) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		31 interacting genes: APP BACH2 BEND7 CASK CCT6A DDIT4L GABARAPL1 GABARAPL2 ID3 KRTAP13-3 LNX1 LNX2 MAD1L1 MEI4 MEOX1 MEOX2 MLXIP MLXIPL MNT MXD1 MXD4 PIAS2 RBM39 RHBDD2 SAP30BP TEPSIN TLE5 TNNT2 UBE2I ZBTB32 ZNF620	3 interacting genes: CNPY2 MLX YWHAB
Entrez ID		6945	22877
HPRD ID		04278	10478
Ensembl ID		ENSG00000108788	ENSG00000175727
Uniprot IDs		Q9UH92	Q9HAP2
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II Protein Dimerization Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process DNA Binding Somite Specification RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Cellular Response To Nitrogen Starvation Regulation Of Macromolecule Metabolic Process Phosphatidylethanolamine Binding Regulation Of Gene Expression Segment Specification Somite Development GABA Receptor Binding Positive Regulation Of ATP-dependent Activity SUMO Transferase Activity Regulation Of Metabolic Process Positive Regulation Of Glycolytic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To Leptomycin B Leptomycin B Binding Regulation Of ATP-dependent Activity SUMO Conjugating Enzyme Activity MAD1 Complex Carbohydrate Response Element Binding Primary Adaptive Immune Response Involving T Cells And B Cells Coated Vesicle Membrane Positive Regulation Of ATP Metabolic Process Negative Regulation Of Metabolic Process
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