MLX and MLXIP

Number of citations of the paper that reports this interaction (PMID 11073985)
24

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		MLX	MLXIP
Gene Name		MLX, MAX dimerization protein	MLX interacting protein
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Mitochondrial Outer Membrane
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Homodimerization Activity Protein Heterodimerization Activity	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Energy Reserve Metabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Nucleocytoplasmic Transport Positive Regulation Of Cellular Metabolic Process Small Molecule Metabolic Process Negative Regulation Of Transcription, DNA-templated	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Nucleocytoplasmic Transport Regulation Of Carbohydrate Metabolic Process By Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Integration of energy metabolism ChREBP activates metabolic gene expression
Drugs
Diseases
GWAS		Crohn's disease ( 21102463)	Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) ( 23648065)
Protein-Protein Interactions		13 interactors: AES APP GABARAPL2 ID3 MAD1L1 MLXIP MLXIPL MNT MXD1 MXD4 RBM39 SAP30BP ZBTB32	3 interactors: CNPY2 MLX YWHAB
Entrez ID		6945	22877
HPRD ID		04278	10478
Ensembl ID		ENSG00000108788
Uniprot IDs		Q9UH92	Q9HAP2
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Cell Cycle Regulation Of Cellular Process Cellular Metabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Carbohydrate Metabolic Process By Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metaphase Plate Congression Glucose Mediated Signaling Pathway Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Protein Metabolic Process Synaptic Growth At Neuromuscular Junction Regulation Of Protein Processing Carbohydrate Mediated Signaling Collateral Sprouting In Absence Of Injury Negative Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Oxidative Phosphorylation Positive Regulation Of Anoikis Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Protein Binding	Negative Regulation Of Gene Expression Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Negative Regulation Of Protein Dephosphorylation Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Receptor Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Receptor Biosynthetic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Cytoplasmic Sequestering Of Protein Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Hippo Signaling Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Tagcloud ?		accumulate acetyltransferase adapt bhlhzip circuitry defective fitness fundamental glucose helix homeostasis intracellular leucine mechanistic mondoa next occupancy organismal requirement respond sense simply steps stimulate stimulates transcriptionally trigger underlies zipper
Tagcloud (Difference) ?		accumulate acetyltransferase adapt bhlhzip circuitry defective fitness fundamental glucose helix homeostasis intracellular leucine mechanistic mondoa next occupancy organismal requirement respond sense simply steps stimulate stimulates transcriptionally trigger underlies zipper
Tagcloud (Intersection) ?