MIR34C and DDX21

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIR34C	DDX21
Description		microRNA 34c	DExD-box helicase 21
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Mitochondrion Cytosol Membrane B-WICH Complex
	Molecular Function	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding MRNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity RRNA Binding SnoRNA Binding MiRNA Binding Identical Protein Binding 7SK SnRNA Binding RNA Polymerase Inhibitor Activity
	Biological Process	Negative Regulation Of Cell Population Proliferation MiRNA-mediated Post-transcriptional Gene Silencing Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Connective Tissue Replacement	Osteoblast Differentiation Immune System Process Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Chromatin Remodeling RRNA Processing Transcription By RNA Polymerase II Response To Virus Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Defense Response To Virus R-loop Processing
Pathways			B-WICH complex positively regulates rRNA expression Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma or allergic disease (pleiotropy) ( 29785011) Bipolar disorder ( 31043756) Waist-hip index ( 34021172)	Depression (quantitative trait) ( 20800221)
Interacting Genes		78 interacting genes: AIMP1 AIMP2 APOBEC3B C1QBP DARS1 DDX1 DDX21 DDX3X DHX36 EDC4 EIF2AK2 EPRS1 FAM98A FUS HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LRPPRC MARS1 MATR3 MSI1 MSI2 NOL6 NONO NUDT21 PDCD11 PRMT1 PTBP1 PTBP3 PTCD3 PUF60 PURA QARS1 QKI RARS1 RBFOX2 RBM14 RBM4 RBMS2 RTCA RTCB SF3B1 SF3B2 SF3B3 SF3B4 SFPQ STRBP SYNCRIP TAF15 TRA2A TRA2B U2SURP UPF1 UTP20 XRN1 YBX1 YBX2 YBX3 ZNF346 ZNF385A	88 interacting genes: CALM1 CSNK2A1 DUX4 ERG H2AX IL7R JUN MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PIAS1 PTEN RBFOX2 RPL34 SUMO2 TERF1 TERF2 UBE2I USP7
Entrez ID		407042	9188
HPRD ID			05895
Ensembl ID		ENSG00000207562	ENSG00000165732
Uniprot IDs			A0A8I5KYZ4 Q9NR30
PDB IDs			2M3D 6L5L 6L5M 6L5N 6L5O
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process RNA Splicing Nucleic Acid Metabolic Process MRNA Processing MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of RNA Splicing MRNA Binding Post-transcriptional Regulation Of Gene Expression Aminoacyl-tRNA Synthetase Multienzyme Complex Nucleus Macromolecule Metabolic Process Regulation Of Translation MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Ribonucleoprotein Complex MRNA 3'-UTR Binding Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing Nucleoplasm Regulation Of MRNA Splicing, Via Spliceosome Spliceosomal Complex Regulation Of Gene Expression Negative Regulation Of Translation Catalytic Step 2 Spliceosome Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Catabolic Process MiRNA Binding Negative Regulation Of MRNA Catabolic Process Regulation Of Macromolecule Metabolic Process RNA Stabilization Regulation Of Primary Metabolic Process MRNA Stabilization Cytoplasmic Stress Granule Regulation Of Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity TRNA Aminoacylation Positive Regulation Of Gene Expression Regulation Of MRNA Stability Positive Regulation Of Cytoplasmic Translation Regulation Of RNA Stability Ligase Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cytoplasmic Translation	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process MRNA Destabilization RNA Destabilization Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Locomotion Regulation Of Metabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Cytokine Production Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Angiogenesis Regulation Of Vasculature Development Regulation Of Translation Regulation Of MRNA Stability Negative Regulation Of Protein Metabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Cell Migration Regulation Of RNA Stability Negative Regulation Of Developmental Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Endothelial Cell Migration Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Signaling
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