MIR18A and CPSF1

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIR18A	CPSF1
Description		microRNA 18a	cleavage and polyadenylation specific factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space RISC Complex Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex
	Molecular Function	MRNA Base-pairing Post-transcriptional Repressor Activity	Nucleic Acid Binding RNA Binding Protein Binding Enzyme Binding MRNA 3'-UTR AU-rich Region Binding
	Biological Process	Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Osteoblast Differentiation Positive Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Extracellular Matrix Assembly Negative Regulation Of Sprouting Angiogenesis Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching	MRNA Processing RNA 3'-end Processing Co-transcriptional RNA 3'-end Processing, Cleavage And Polyadenylation Pathway
Pathways			Transport of Mature mRNA Derived from an Intronless Transcript tRNA processing in the nucleus mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Drugs
Diseases
GWAS			Educational attainment ( 25201988)
Interacting Genes		72 interacting genes: AIMP2 APOBEC3B C1QBP CPSF1 CRTAP DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EIF2AK2 EPRS1 FAM98A FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KNOP1 LARP7 LARS1 LIN28A LRPPRC MARS1 MATR3 MSI1 MSI2 NOL6 NONO NUDT21 NUFIP2 PDCD11 PLOD1 PTBP1 PTBP3 PUF60 QARS1 RARS1 RBFOX2 RBM14 RTCA RTCB SART3 SF3A1 SF3B1 SF3B2 SF3B3 SFPQ SYMPK SYNCRIP TAF15 TRA2A TRA2B U2SURP UPF1 UTP20 YBX1 YBX3 ZFR	58 interacting genes: CSTF2T GLIS2 HMOX1 IL7R INCA1 MCM2 MIR1-2 MIR106B MIR107 MIR122 MIR128-2 MIR138-1 MIR138-2 MIR143 MIR155 MIR15A MIR15B MIR16-2 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200C MIR205 MIR206 MIR20B MIR21 MIR214 MIR221 MIR29A MIR31 MIR34A MIR34B MIR7-1 MIR92A1 MIR92A2 MIR98 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7E MIRLET7F2 MIRLET7G MIRLET7I NEDD4 PAPOLA POLR2A PRRC2A REL TAF11 TAF12 TAF13 TAF5 TAF7 UBC
Entrez ID		406953	29894
HPRD ID			05823
Ensembl ID		ENSG00000283815	ENSG00000071894
Uniprot IDs			Q10570
PDB IDs			6BLY 6BM0 6DNH 6F9N 6FUW 6URG 6URO 8E3I 8E3Q 8R8R
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process RNA Splicing MRNA Processing Nucleic Acid Metabolic Process MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding MRNA Splicing, Via Spliceosome Regulation Of MRNA Metabolic Process RNA Splicing, Via Transesterification Reactions Macromolecule Metabolic Process Regulation Of RNA Splicing Nucleus Aminoacyl-tRNA Synthetase Multienzyme Complex Spliceosomal Complex Catalytic Step 2 Spliceosome Ribonucleoprotein Complex Nucleoplasm Negative Regulation Of MRNA Metabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Cytoplasmic Stress Granule Negative Regulation Of RNA Catabolic Process Regulation Of Translation Negative Regulation Of MRNA Catabolic Process RNA Stabilization MRNA 3'-UTR Binding MRNA Stabilization Positive Regulation Of Cytoplasmic Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Regulation Of Macromolecule Metabolic Process TRNA Aminoacylation Regulation Of MRNA Stability Regulation Of Primary Metabolic Process CRD-mediated MRNA Stabilization MRNA 5'-UTR Binding RNA Transport Regulation Of RNA Stability Ligase Activity Positive Regulation Of Gene Expression Negative Regulation Of Translation Nucleolus TRNA Metabolic Process	RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Extracellular Vesicle MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Angiogenesis Regulation Of Gene Expression Regulation Of Vasculature Development Negative Regulation Of Cytokine Production Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Metabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Translation Negative Regulation Of Cell Motility Negative Regulation Of Locomotion MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Endothelial Cell Migration Negative Regulation Of Multicellular Organismal Process Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cytokine Production Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Protein Metabolic Process Regulation Of MRNA Stability Negative Regulation Of Signal Transduction Regulation Of Endothelial Cell Proliferation Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of RNA Stability Extracellular Space Regulation Of Translation Negative Regulation Of Cell Communication
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