MIR15A and AIMP1

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIR15A	AIMP1
Description		microRNA 15a	aminoacyl tRNA synthetase complex interacting multifunctional protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space RISC Complex Extracellular Exosome Extracellular Vesicle	Extracellular Region Extracellular Space Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Cell Surface Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex
	Molecular Function	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity	TRNA Binding RNA Binding Cytokine Activity Protein Binding Protein Homodimerization Activity GTPase Binding
	Biological Process	Negative Regulation Of Cell Population Proliferation Negative Regulation Of Angiogenesis MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Positive Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Inflammatory Response Cellular Response To Glucose Stimulus Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Cell Chemotaxis To Fibroblast Growth Factor Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Angiogenesis Negative Regulation Of Endothelial Cell Proliferation Translation Apoptotic Process Inflammatory Response Signal Transduction Cell-cell Signaling Blood Vessel Morphogenesis Leukocyte Migration Defense Response To Virus Positive Regulation Of Glucagon Secretion
Pathways			Selenoamino acid metabolism Cytosolic tRNA aminoacylation Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Diseases			Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD)
GWAS
Interacting Genes		73 interacting genes: AIMP1 AIMP2 C1QBP CPSF1 DARS1 DDX1 DDX21 DDX3X DDX49 DHX36 DHX37 EIF2AK2 EPRS1 ERAL1 FAM98A FUS HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 MYEF2 NOL6 NONO NUDT21 PDCD11 PGAM5 PLOD1 PRMT1 PTBP1 PUF60 QARS1 RARS1 RBM14 RTCA RTCB SF3A1 SF3B1 SF3B2 SF3B3 SFPQ SPOUT1 SYNCRIP TAF15 TRA2A TRA2B TRIM71 TRMT10C UPF1 UTP20 YBX1 YBX3 ZNF346	51 interacting genes: AIMP2 APP ATP5F1A HOMER1 IQGAP1 LINC01232 MAPK14 MAPK8 MIR106B MIR107 MIR122 MIR128-1 MIR128-2 MIR138-2 MIR140 MIR15A MIR15B MIR17 MIR199A1 MIR199A2 MIR19B1 MIR19B2 MIR205 MIR206 MIR20B MIR214 MIR222 MIR25 MIR29C MIR31 MIR34A MIR34B MIR34C MIR451A MIR7-1 MIR7-2 MIR7-3 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7I OPTN RARS1 SUMO2 TSNAX
Entrez ID		406948	9255
HPRD ID			04676
Ensembl ID		ENSG00000283785	ENSG00000164022
Uniprot IDs			B4DNK3 Q12904
PDB IDs			1E7Z 1EUJ 1FL0 4R3Z 8J9S 8ONG
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process Nucleic Acid Metabolic Process RNA Splicing MRNA Processing Nucleobase-containing Compound Metabolic Process MRNA Metabolic Process Aminoacyl-tRNA Synthetase Multienzyme Complex Macromolecule Metabolic Process Regulation Of MRNA Metabolic Process Post-transcriptional Regulation Of Gene Expression MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Binding Regulation Of RNA Splicing Ribonucleoprotein Complex Nucleoplasm Nucleus Spliceosomal Complex Catalytic Step 2 Spliceosome Negative Regulation Of MRNA Metabolic Process Regulation Of Translation MiRNA Binding Regulation Of RNA Stability Negative Regulation Of RNA Catabolic Process Regulation Of MRNA Processing Negative Regulation Of MRNA Catabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Gene Expression RNA Stabilization Regulation Of Macromolecule Biosynthetic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity MRNA 3'-UTR Binding TRNA Aminoacylation MRNA Stabilization Positive Regulation Of Gene Expression Negative Regulation Of Translation Regulation Of Macromolecule Metabolic Process TRNA Metabolic Process Regulation Of MRNA Stability Positive Regulation Of Cytoplasmic Translation Ligase Activity Positive Regulation Of Macromolecule Biosynthetic Process Nucleolus Regulation Of Primary Metabolic Process Cytoplasmic Stress Granule Regulation Of Metabolic Process	Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Extracellular Vesicle Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Vascular Endothelial Growth Factor Production MRNA Destabilization Regulation Of Gene Expression RNA Destabilization Negative Regulation Of Cytokine Production Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of MRNA Catabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Metabolic Process Positive Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability Positive Regulation Of Connective Tissue Replacement Regulation Of Angiogenesis Regulation Of RNA Stability Regulation Of Vasculature Development Regulation Of Cytokine Production Negative Regulation Of Angiogenesis Regulation Of Connective Tissue Replacement Negative Regulation Of Vasculature Development Negative Regulation Of Translation Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Endothelial Cell Migration Negative Regulation Of Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Motility Regulation Of Cell Migration Involved In Sprouting Angiogenesis Extracellular Space Negative Regulation Of Locomotion Positive Regulation Of Tissue Remodeling Regulation Of MRNA Metabolic Process Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
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