MIR15A and LIN28A

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIR15A	LIN28A
Description		microRNA 15a	lin-28 RNA binding posttranscriptional regulator A
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space RISC Complex Extracellular Exosome Extracellular Vesicle	P-body Nucleus Nucleolus Cytoplasm Endoplasmic Reticulum Rough Endoplasmic Reticulum Cytosol Cytoplasmic Stress Granule
	Molecular Function	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity	G-quadruplex RNA Binding Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Zinc Ion Binding Translation Initiation Factor Binding MiRNA Binding Metal Ion Binding Pre-miRNA Binding Protein-RNA Adaptor Activity Sequence-specific MRNA Binding
	Biological Process	Negative Regulation Of Cell Population Proliferation Negative Regulation Of Angiogenesis MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Positive Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Inflammatory Response Cellular Response To Glucose Stimulus Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Cell Chemotaxis To Fibroblast Growth Factor Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Germ Cell Development MiRNA Metabolic Process MiRNA Catabolic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Translation Stem Cell Population Maintenance Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing RNA 3'-end Processing Positive Regulation Of TOR Signaling Positive Regulation Of Neuron Differentiation Negative Regulation Of Glial Cell Differentiation Positive Regulation Of Translation Stem Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of MiRNA-mediated Gene Silencing Cellular Response To Glucose Stimulus Positive Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Pre-miRNA Processing Positive Regulation Of Cytoplasmic Translation
Pathways			Transcriptional regulation of pluripotent stem cells
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823) Caffeine consumption from tea ( 33287642) Glucose homeostasis traits ( 25524916) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494)
Interacting Genes		73 interacting genes: AIMP1 AIMP2 C1QBP CPSF1 DARS1 DDX1 DDX21 DDX3X DDX49 DHX36 DHX37 EIF2AK2 EPRS1 ERAL1 FAM98A FUS HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 MYEF2 NOL6 NONO NUDT21 PDCD11 PGAM5 PLOD1 PRMT1 PTBP1 PUF60 QARS1 RARS1 RBM14 RTCA RTCB SF3A1 SF3B1 SF3B2 SF3B3 SFPQ SPOUT1 SYNCRIP TAF15 TRA2A TRA2B TRIM71 TRMT10C UPF1 UTP20 YBX1 YBX3 ZNF346	74 interacting genes: MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PTBP1 TRIM28 ZDHHC17 ZNF275
Entrez ID		406948	79727
HPRD ID			17278
Ensembl ID		ENSG00000283785	ENSG00000131914
Uniprot IDs			Q9H9Z2
PDB IDs			2CQF 2LI8 5UDZ 8OPS 8OPT 8OST
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process Nucleic Acid Metabolic Process RNA Splicing MRNA Processing Nucleobase-containing Compound Metabolic Process MRNA Metabolic Process Aminoacyl-tRNA Synthetase Multienzyme Complex Macromolecule Metabolic Process Regulation Of MRNA Metabolic Process Post-transcriptional Regulation Of Gene Expression MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Binding Regulation Of RNA Splicing Ribonucleoprotein Complex Nucleoplasm Nucleus Spliceosomal Complex Catalytic Step 2 Spliceosome Negative Regulation Of MRNA Metabolic Process Regulation Of Translation MiRNA Binding Regulation Of RNA Stability Negative Regulation Of RNA Catabolic Process Regulation Of MRNA Processing Negative Regulation Of MRNA Catabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Gene Expression RNA Stabilization Regulation Of Macromolecule Biosynthetic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity MRNA 3'-UTR Binding TRNA Aminoacylation MRNA Stabilization Positive Regulation Of Gene Expression Negative Regulation Of Translation Regulation Of Macromolecule Metabolic Process TRNA Metabolic Process Regulation Of MRNA Stability Positive Regulation Of Cytoplasmic Translation Ligase Activity Positive Regulation Of Macromolecule Biosynthetic Process Nucleolus Regulation Of Primary Metabolic Process Cytoplasmic Stress Granule Regulation Of Metabolic Process	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cytokine Production Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Migration Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Angiogenesis Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Vasculature Development Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Translation Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Developmental Process Regulation Of Cellular Response To Growth Factor Stimulus Extracellular Space Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of MRNA Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Migration Regulation Of Endothelial Cell Migration Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Motility Negative Regulation Of Signal Transduction
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?