MIR126 and PLK4

Number of citations of the paper that reports this interaction (PubMedID 30315225)
38

Data Source:
BioGRID (unspecified method)

		MIR126	PLK4
Description		microRNA 126	polo like kinase 4
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space RISC Complex Extracellular Vesicle	XY Body Nucleus Nucleolus Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cleavage Furrow Deuterosome Procentriole Procentriole Replication Complex
	Molecular Function	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Cell Migration MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Angiogenesis Negative Regulation Of Proteolysis Positive Regulation Of Inflammatory Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Laminar Fluid Shear Stress Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Vasculature Development Negative Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of Endothelial Cell Apoptotic Process	Protein Phosphorylation Centriole Replication Regulation Of Cell Cycle Process Positive Regulation Of Centriole Replication Cilium Assembly Trophoblast Giant Cell Differentiation De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs			Fostamatinib
Diseases
GWAS
Interacting Genes		1 interacting genes: PLK4	25 interacting genes: ACTR2 AIRIM ARR3 BTRC CHD3 CYLD DCAF1 DNAJB13 DRC4 ELOA MIR126 MTUS2 OSBPL3 PRDM16 SFN SMAD4 SPAG5 TAX1BP3 TEC TENT5B TENT5C TFIP11 TGFBR1 TRIM54 ZBTB39
Entrez ID		406913	10733
HPRD ID			10387
Ensembl ID		ENSG00000199161	ENSG00000142731
Uniprot IDs			O00444
PDB IDs			2N19 3COK 4JXF 4N7V 4N7Z 4N9J 4YUR 4YYP 5LHY 5LHZ 6N45 6N46 6W38 6W3I 6W3J 8XPG
Enriched GO Terms of Interacting Partners?		De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation De Novo Centriole Assembly Procentriole Replication Complex Procentriole Deuterosome Positive Regulation Of Centriole Replication XY Body Trophoblast Giant Cell Differentiation Centriole Replication Regulation Of Centriole Replication Cell Differentiation Involved In Embryonic Placenta Development Centriole Assembly Regulation Of Centrosome Duplication Cleavage Furrow Regulation Of Centrosome Cycle Microtubule Organizing Center Organization Positive Regulation Of Organelle Assembly Centriole Positive Regulation Of Cytoskeleton Organization	Cytoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Centrosome Cytoskeleton Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Microtubule Negative Regulation Of Cell Population Proliferation Positive Regulation Of Extracellular Matrix Assembly Endothelial Cell Activation Poly(A) RNA Polymerase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process I-SMAD Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of T Cell Receptor Signaling Pathway Microtubule Binding Regulation Of Extracellular Matrix Assembly Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Extracellular Matrix Organization Microtubule-based Process Regulation Of Cytoskeleton Organization Activin Receptor Signaling Pathway Cardiac Epithelial To Mesenchymal Transition Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Centriolar Satellite Regulation Of Primary Metabolic Process Ciliary Basal Body Phosphoprotein Binding Negative Regulation Of Interleukin-18-mediated Signaling Pathway Regulation Of Wnt Signaling Pathway Met1-linked Polyubiquitin Deubiquitinase Activity Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Histone H2AT120 Kinase Activity Cell Competition In A Multicellular Organism Neuron Fate Commitment Ventricular Septum Morphogenesis Nucleus Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of Wnt Signaling Pathway
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