CUEDC1 and UBASH3A

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		CUEDC1	UBASH3A
Description		CUE domain containing 1	ubiquitin associated and SH3 domain containing A
Image
GO Annotations	Cellular Component		Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Extracellular Exosome
	Molecular Function	Protein Binding Ubiquitin Binding	Protein Binding
	Biological Process		Regulation Of Cytokine Production Negative Regulation Of T Cell Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Mean platelet volume ( 32888494) Multiple sclerosis--Brain Glutamate Levels ( 20802204) Tenofovir clearance in HIV infection ( 26148204)	Addison's disease ( 33574239) Asthma ( 32296059) Autoimmune traits (pleiotropy) ( 30572963) Celiac disease ( 22057235 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Diverticular disease ( 30177863) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte count ( 32888494) Medication use (thyroid preparations) ( 31015401) Primary sclerosing cholangitis ( 27992413) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Type 1 diabetes ( 18840781 30572963 25751624 21829393 19430480) Vitiligo ( 27723757 20410501)
Interacting Genes		19 interacting genes: ABI2 IKBKG LRRK2 MAP3K1 MFHAS1 NCK2 NEDD4 NEDD4L NTAQ1 OSTF1 SMARCD1 SMURF1 SMURF2 UBASH3A UBC UBE2D2 UBE2E2 UBE2E3 WBP2	105 interacting genes: ARRDC1 ARRDC3 ATF6 BCAR3 CBLB CBS CCDC33 CD3E COPS9 CUEDC1 CXXC5 DAZAP2 DDIT4L DISC1 DLG1 DLGAP4 DNM2 DTX3 EHMT2 FADS6 FAM83A FGFR1OP2 GFAP GOLGA6L9 HSP90AA1 HSP90B1 HSPD1 IKBKG ISY1-RAB43 KCNE1 KCTD1 KIAA0408 KPRP KRT14 KRT31 KRT32 KRT35 KRT39 KRT40 LCN2 LNX1 LZTS1 LZTS2 MAP3K7 MKRN1 MTIF2 N4BP3 NEUROD2 NSMF PDE7A PFDN2 PLEKHB2 PMEPA1 PNMA5 PRDM6 PRKN PSMC1 PSMC4 REL RNF216 RNF41 SF3B4 SH3RF1 SHISA6 SLA2 SLC4A3 SNRNP48 SOS1 SOS2 SPMIP6 SPRY1 SPRY2 SPRYD7 STX11 TAOK1 TAX1BP1 TEKT1 TEKT4 TIMM44 TMCO2 TMEM239 TP53BP2 TP63 TRIM27 TRIM37 TRIM5 TRIM50 TRIM8 TUBB8 UBB UBC UBE2L3 VCP VPS37B VPS72 WAS WASL WBP11 YPEL3 ZBTB42 ZC2HC1C ZIC3 ZNF219 ZNF474 ZRANB1
Entrez ID		404093	53347
HPRD ID		13098	06904
Ensembl ID		ENSG00000180891	ENSG00000160185
Uniprot IDs		Q9NWM3	P57075
PDB IDs		2DHY	2CRN 5WDI
Enriched GO Terms of Interacting Partners?		Ubiquitin-protein Transferase Activity Protein Modification Process Protein Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein Monoubiquitination Receptor Catabolic Process Post-translational Protein Modification Protein K48-linked Ubiquitination Ubiquitin Conjugating Enzyme Activity Protein Metabolic Process Neuromuscular Junction Development Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Potassium Ion Export Across Plasma Membrane Receptor Metabolic Process Negative Regulation Of Response To Endoplasmic Reticulum Stress Cytosol Modification-dependent Protein Catabolic Process Sodium Channel Inhibitor Activity Ubiquitin Protein Ligase Activity Transferase Activity Potassium Channel Inhibitor Activity Negative Regulation Of Signal Transduction Proteolysis Involved In Protein Catabolic Process Regulation Of Potassium Ion Export Across Plasma Membrane Progesterone Receptor Signaling Pathway Protein K63-linked Ubiquitination Regulation Of Neuron Projection Development Signaling Adaptor Activity Negative Regulation Of Sodium Ion Transport Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cytoplasm Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Protein Metabolic Process Nucleoplasm Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Dendrite Extension Ubiquitin Ligase Complex Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Potassium Ion Transmembrane Transport Cytoskeletal Anchor Activity MAP Kinase Kinase Kinase Activity Positive Regulation Of Catabolic Process Regulation Of Synapse Organization Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Transmembrane Transporter Binding	Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Inclusion Body Assembly Post-translational Protein Modification Ubiquitin Protein Ligase Activity Intermediate Filament Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Structural Constituent Of Skin Epidermis Supramolecular Fiber Organization Identical Protein Binding Aggresome Assembly Proteolysis Involved In Protein Catabolic Process Morphogenesis Of An Epithelium Positive Regulation Of Catabolic Process Sperm Plasma Membrane WW Domain Binding Protein Binding Regulation Of Post-translational Protein Modification Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Keratin Filament Canonical NF-kappaB Signal Transduction Negative Regulation Of Membrane Tubulation Cytosol Cytoskeleton Organization Tissue Morphogenesis Positive Regulation Of Protein Catabolic Process Organelle Organization Modification-dependent Protein Catabolic Process Intermediate Filament Protein Polyubiquitination Macromolecule Catabolic Process Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Regulation Of Intracellular Signal Transduction SH3 Domain Binding P53 Binding Protein Localization To Mitochondrion Linear Polyubiquitin Binding Regulation Of Protein Catabolic Process Protein Polymerization Regulation Of Autophagy Regulation Of Signal Transduction Suppression Of Viral Release By Host Positive Regulation Of Protein Metabolic Process Regulation Of Type I Interferon Production Positive Regulation Of Post-translational Protein Modification Ubiquitin-protein Transferase Activity
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