LOX and MYL4

		LOX	MYL4
Description		lysyl oxidase	myosin light chain 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Extracellular Matrix	Cytosol Myosin Complex Myosin II Complex A Band
	Molecular Function	Protein-lysine 6-oxidase Activity Copper Ion Binding Protein Binding Collagen Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, Oxygen As Acceptor Small Molecule Binding Metal Ion Binding Molecular Adaptor Activity	Actin Monomer Binding Calcium Ion Binding Myosin II Heavy Chain Binding Actin Filament Binding
	Biological Process	Blood Vessel Development Osteoblast Differentiation Heart Development Response To Xenobiotic Stimulus Response To Hormone Regulation Of Gene Expression Regulation Of Striated Muscle Tissue Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Peptidyl-lysine Oxidation Collagen Fibril Organization Bone Mineralization Lung Development Platelet-derived Growth Factor Receptor-beta Signaling Pathway Aorta Development Ascending Aorta Development Descending Aorta Development Protein Modification Process Regulation Of Apoptotic Process Regulation Of Megakaryocyte Differentiation Muscle Cell Cellular Homeostasis Elastic Fiber Assembly Blood Vessel Morphogenesis Response To Steroid Hormone Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Muscle Cell Development Cell Chemotaxis Connective Tissue Development DNA Biosynthetic Process Regulation Of Bone Development Cellular Response To Chemokine Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Regulation Of The Force Of Heart Contraction Muscle Contraction Cardiac Muscle Contraction
Pathways		Elastic fibre formation Crosslinking of collagen fibrils	Striated Muscle Contraction
Drugs
Diseases
GWAS		Central corneal thickness ( 32528159) Coronary artery disease ( 28714974) Intraocular pressure ( 29617998) Keratoconus ( 33649486) Lung function (FEV1/FVC) ( 30804560) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Waist circumference adjusted for body mass index ( 34021172) Youthful appearance (self-reported) ( 32339537)	Body mass index ( 26426971) Erythema nodosum in inflammatory bowel disease ( 24487271)
Interacting Genes		8 interacting genes: DHDDS DPT ELN H1-1 H1-5 H2BC11 H2BC21 MRE11	1 interacting genes: PYROXD2
Entrez ID		4015	4635
HPRD ID		01087	01176
Ensembl ID		ENSG00000113083	ENSG00000198336
Uniprot IDs		B0AZT2 B7ZAJ4 D0PNI2 P28300	P12829
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Chromatin Nucleosome Nucleosome Assembly Nucleosome Organization Chromatin Remodeling Chromosome Protein-DNA Complex Assembly Chromatin Organization Innate Immune Response In Mucosa Double-stranded DNA Binding Negative Regulation Of DNA Metabolic Process Regulation Of DNA Recombination Phosphatidylinositol Phosphate Binding Mucosal Immune Response Organ Or Tissue Specific Immune Response Chromosome Condensation Nucleosomal DNA Binding Regulation Of DNA Metabolic Process Negative Regulation Of DNA Recombination Mitochondrial Double-strand Break Repair Via Homologous Recombination Nicotinamide Phosphoribosyltransferase Activity Polyprenol Biosynthetic Process Dehydrodolichyl Diphosphate Synthase Complex Ditrans,polycis-polyprenyl Diphosphate Synthase [(2E,6E)-farnesyl Diphosphate Specific] Activity Euchromatin Antibacterial Humoral Response Myosin II Heavy Chain Binding Histone H2AXY142 Phosphatase Activity Chromatin DNA Binding	Descending Aorta Development Ascending Aorta Development Peptidyl-lysine Oxidation Platelet-derived Growth Factor Receptor-beta Signaling Pathway Protein-lysine 6-oxidase Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, Oxygen As Acceptor Protein Oxidation Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Bone Development Elastic Fiber Assembly Cellular Response To Chemokine Oxidoreductase Activity Muscle Cell Cellular Homeostasis Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Small Molecule Binding
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